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Role Of Bpifb4 In Immune System And Cardiovascular Disease: The Lesson From Centenarians, Francesco Montella, Valentina Lopardo, Monica Cattaneo, Albino Carrizzo, Carmine Vecchione, Elena Ciaglia, Annibale A. Puca
Role Of Bpifb4 In Immune System And Cardiovascular Disease: The Lesson From Centenarians, Francesco Montella, Valentina Lopardo, Monica Cattaneo, Albino Carrizzo, Carmine Vecchione, Elena Ciaglia, Annibale A. Puca
Translational Medicine @ UniSa
Recent discoveries have shed light on the participation of the immune system in the physio pathology of the cardiovascular system underpinning the importance of keeping the balance of the first to preserve the latter. Aging, along with other risk factors, can challenge such balance triggering the onset of cardiovascular diseases.
Among several mediators ensuring the proper cross-talk between the two systems, bactericidal/permeability-increasing fold-containing family B member 4 (BPIFB4) has been shown to have a pivotal role, also by sustaining important signals such as eNOS and PKC-alpha.
In addition, the Longevity-associated variant (LAV), which is an haplotype allele in BPIFB4characterized by …