Medicine and Health Sciences Commons^™

Abdominal Aortic Aneurysm: Natural History, Pathophysiology And Translational Perspectives, Giulio Accarino, Antonio Nicola Giordano, Martina Falcone, Adriana Celano, Maria Giovanna Vassallo, Giovanni Fornino, Umberto Marcello Bracale, Carmine Vecchione, Gennaro Galasso

Translational Medicine @ UniSa

An abdominal aortic aneurysm (AAA) is a degenerative pathology that affects the infrarenal segment of the aorta, leading to its progressive dilatation and eventually rupture. The infrarenal segment is involved in 80% of the aortic aneurisms, and represents alone 30% of all aneurysms. The natural history of the disease is characterized by the progressive increase of the aortic diameter associated with proportionally higher risk of rupture, particularly for cases with diameter greater than 5.5 cm. In case of rupture the mortality rate is very high, independently from the endovascular or surgical treatment. The most important risk factors are older age, …