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Full-Text Articles in Medicine and Health Sciences
Efficacy Of Hmj-38, A New Quinazolinone Analogue, Against The Gemcitabine-Resistant Mia-Paca-2 Pancreatic Cancer Cells, Mann-Jen Hour, Fuu‑ Jen Tsai, I-Lu Lai, Je-Wei Tsao, Jo-Hua Chiang, Yu-Jen Chiu, Hsing-Fang Lu, Yu‑ Ning Juan, Jai-Sing Yang, Shih-Chang Tsai
Efficacy Of Hmj-38, A New Quinazolinone Analogue, Against The Gemcitabine-Resistant Mia-Paca-2 Pancreatic Cancer Cells, Mann-Jen Hour, Fuu‑ Jen Tsai, I-Lu Lai, Je-Wei Tsao, Jo-Hua Chiang, Yu-Jen Chiu, Hsing-Fang Lu, Yu‑ Ning Juan, Jai-Sing Yang, Shih-Chang Tsai
BioMedicine
Gemcitabine is frequently utilized to treat pancreatic cancer. The purpose of our study was to create a gemcitabine-resistant MIA-PaCa-2 pancreatic cancer cell line (MIAGR100) and to evaluate the anti-pancreatic cancer efficacy of HMJ-38, a new quinazolinone analogue. Compared to their parental counterparts, MIA-PaCa-2, established MIA-GR100 cells were less sensitive to gemcitabine. MIA-GR100 cell viability was not affected by 10, 50, or 100 nM gemcitabine concentrations. HMJ-38 reduced MIA-GR100 cell growth and induced autophagy and apoptosis. When stained with monodansylcadaverine (MDC), acridine orange (AO), and terminal deoxynucleotide transferase dUTP nick end labeling (TUNEL), MIA-GR100 cells shrunk, punctured their membranes, and produced …
Metformin Induces Autophagy Of Cisplatin-Resistant Human Gastric Cancer Cells In Addition To Apoptosis, Chih-Wun Fang, Jai-Sing Yang, Jo-Hua Chiang, Po-Chuen Shieh, Fuu-Jen Tsai, Chia-Wen Tsai, Wen-Shin Chang
Metformin Induces Autophagy Of Cisplatin-Resistant Human Gastric Cancer Cells In Addition To Apoptosis, Chih-Wun Fang, Jai-Sing Yang, Jo-Hua Chiang, Po-Chuen Shieh, Fuu-Jen Tsai, Chia-Wen Tsai, Wen-Shin Chang
BioMedicine
Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act alone or in synergy with other anticancer agents to achieve anti-cancer efficacies on various types of tumors. However, the role of metformin in either inducing autophagy and cisplatin-resistance of human gastric cancer (GC) cells has never been examined. The study has established a cisplatin-resistant GC cell line and investigated the effects of metformin on inducing autophagy on it. The results demonstrated that treatment with metformin can concentration-dependently suppress the cell viability and cell confluence of cisplatin-resistant GC cells, while …