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The Effect Of Shear Stress, Potassium, And Adenosine On Α-1 Adrenergic Vasoconstriction Of Rat Soleus Feed Arteries, Tanner J. Heckle

Seaver College Research And Scholarly Achievement Symposium

During exercise, sympathetic nerve activity increases, augmenting the release of the neurotransmitter norepinephrine (NE) at the arterial wall and into the blood. NE binds to arterial adrenergic receptors to cause vasoconstriction, yet arteries in contracting skeletal muscle dilate during exercise. Previous evidence from Ives et al. suggests that heat and acidosis may partially inhibit constriction resulting from α-1 adrenergic receptors (termed sympatholysis). Our lab has previously demonstrated that rat soleus feed arteries respond to sympathetic signaling solely by α-1 adrenoceptors. We hypothesized that increased levels of arterial wall shear stress, potassium, or adenosine also contribute to sympatholysis, thereby reducing sympathetic …