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Oncolog, Volume 57, Number 11-12, November - December 2012, Kathryn L. Hale, Amelia Scholtz, Luanne Jorewicz

OncoLog MD Anderson's Report to Physicians (All issues)

• Research Explores Link Between Thrombocytosis and Cancer: High platelet counts can be an early indicator of cancer, In fact, about one-third of women with ovarian cancer have an abnormally high platelet count at the time of diagnosis. This paraneoplastic thrombocytosis is also seen in patients with cancers of the gastrointestinal tract, lung or breast
• Wide Range of Cancer Treatments May Produce Ocular Complications: Although most ocular side effects of cancer treatment may be transient and reversible, regular ophthalmic examinations and effective doctor-patient communication can help cancer patients avoid permanent damage
• New Software May Provide a Standardized Reporting System for Diagnostic …

Oncolog, Volume 57, Number 10, October 2012, Jill Delsigne, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Treatments May Alleviate and Reverse Central Nervous System Radiation Necrosis: Although radiation therapy is effective against many tumors of the brain and spine, it also damages normal tissue
• INBRIEF: Bevacizumab With High-Dose Chemotherapy Shows Promise for Cisplatin-Refractory Germ Cell Tumors
• Compass: Early-Stage Testicular Cancer-Postsurgical treatment varies according to tumor stage and histology
• HOUSE CALL: Online Cancer Support Networks-Patients and caregivers find support online

Oncolog, Volume 57, Number 09, September 2012, Zach Bohannan, Sunita Patterson

OncoLog MD Anderson's Report to Physicians (All issues)

• Stereotactic Body Radiation Therapy Achieves High Control Rates in Lung Cancer: Stereotactic body radiation (SBRT), a relatively new treatment modality, has recently become a very successful treatment-and may even exceeded the effectiveness of surgery-for early-stage lung cancer
• Inflammatory Breast Cancer: Clinical Challenge, Research Enigma- Inflammatory breast cancer (IBC) stands apart from other cancers of the breast in its unusual clinical presentation, its aggressiveness, and its poor prognosis. Researchers and clinicians are working to clarify what distinguishes IBC from other breast cancers and to discover treatments that improve patient outcomes
• HOUSE CALL: Reducing Cancer-Causing Chemicals in Outdoor Cooking: Tips for healthy …

Oncolog, Volume 57, Number 08, August 2012, Amelia Scholtz, Dawn Chalaire

OncoLog MD Anderson's Report to Physicians (All issues)

• Preoperative Chemotherapy Offers Best Outcomes for Patients with Rare Bladder Cancer: A combination of neoadjuvant chemotherapy and surgery provides patients who have small-cell urothelial cancer (SCUC) with much longer survival times than does initial surgery, the previous standard treatment
• Addressing Psychological Concerns for Cancer Patients: Despite advances in cancer treatment over the past several years, for many people, a diagnosis of cancer can still feel like a death sentence. The added stress leads to psychological problems for many patterns
• INBRIEF: New Antibody Treatment Produces Responses in Patient with Advanced Cancer/Accelerated Partial-Breast Brachytherapy Associated with Decreased Long-Term Breast Preservation and Increased …

Oncolog, Volume 57, Number 07, July 2012, Kathryn L. Hale, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Geriatricians Play an Increasingly Important Role in Cancer care: In the past, many elderly patients did not survive long after a cancer diagnosis. Even older patients who were healthy enough to undergo the standard treatment for their cancer often had a shorter life expectancy than younger people with the same cancer
• Compass: Early -Stage Cervical Cancer: Treatment choices vary according to disease stage and patient-specific factors
• HOUSE CALL: Exercise and Cancer Prevention: Benefits of exercise apply to a variety of cancers

Oncolog, Volume 57, Number 06, June 2012, Sarah Bronson, Stephanie Deming

OncoLog MD Anderson's Report to Physicians (All issues)

• Minimally Invasive Component Separation Reduces Wound-Healing Complications from Abdominal Surgery: Component separation, a major advance in abdominal wall reconstruction, can prevent hernia recurrence in many patients
• Bevacizumab for Glioblastoma: Symptom Relief Proven, Overall Survival Benefit Being Studied-The antiangiogenic agent bevacizumab has been shown to prolong progression-free survival and ameliorate symptoms in patients with recurrent glioblastoma. However, it remains unknown whether bevacizumab should be used to treat newly diagnosed glioblastoma and whether bevacizumab prolongs the overall survival of patients with glioblastoma
• HOUSE CALL: Hospice Care- Patients and families have choices for care and comfort
• INBRIEF: Panobinostat Elicits Durable Response in Hodgkin …

Oncolog, Volume 57, Number 05, May 2012, Bryan Tutt, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Advances in Gene Mapping Technology May Accelerate Cancer Drug Development: As new technology makes DNA sequencing faster and less expensive, researchers aim to exploit these abilities to develop novel targeted cancer therapies
• Compass: Advanced Renal Cell Carcinoma: Surgery and/or systemic therapy can help manage disease
• HOUSE CALL: Do Nutritional Supplements Help Prevent Cancer ?: For many people, the risks may outweigh the benefits
• INBRIEF: Drug Provides Symptom Reduction and Survival Advantages for Myelofibrosis Patients

Pharmacokinetic/Pharmacodynamic (Pk/Pd) Modeling Of Anti-Neoplastic Agents, Daniel Lexcen, Ahmed H. Salem, Walid F. Elkhatib, Virginia Haynes, Ayman Noreddin

Pharmacy Faculty Books and Book Chapters

"Development of tumor resistance to chemotherapeutics is related to inherent tumor variations regarding sensitivity to chemotherapeutics and to sub-optimal dosing regimens, including variation in patient pharmacokinetics that result in suboptimal exposure of tumor cells to anti-neoplastic drugs [1, 2]. The rate and extent of drug efficacy depends on the extent of drug exposure at the tumor site and the time above the effective concentration [3]. In vitro models that incorporate these pharmacokinetic and pharmacodynamic (PK/PD) principles to optimize therapeutic response may be considered the method of choice for optimizing dosing schedules before translating data from static assays to animals and …

Oncolog, Volume 57, Number 04, April 2012, Joe Munch, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Biology, More Than Chemotherapy Timing, Drives Locoregional Recurrence in Patients Who Undergo Breast-Conserving Therapy: The management of breast cancer, like that of many cancers, often requires a little bit of everything: surgery, radiation therapy, and systemic therapy with chemotherapeutic drugs or other agents
• New Treatments for Acute Myelogenous Leukemia May Improve Patient Outcomes: Acute myelogenous leukemia (AML) is an aggressive and deadly malignancy, nut new treatments are being developed that may prolong remissions
• HOUSE CALL: Controlling Nausea and Vomiting from Chemotherapy: Several techniques can be used to prevent or reduce this side effect

Oncolog, Volume 57, Number 03, March 2012, Zach Bohannan, Sarah Bronson, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Precision Robotic Tools Facilitate Minimally Invasive Prostectomy: Surgeons face a treacherous landscape when they perform a proctectomy
• Fluorescence Cystoscopy Detects Hard-to-Find Bladder Tumors: Fluorescence cystoscopy, although not yet widely used in United States, has been shown to be effective for detecting tumors in the bladder that might not be visible with standard cystoscopy
• New HPV Vaccine Recommendations Could Have Multiple Benefits: New recommendations for vaccination against human papillomavirus (HPV) are intended to prevent cervical cancer but may also decrease the incidence rates of other cancers
• HOUSE CALL: Tanning Beds Pose Health Risks: Dangers of tanning range from wrinkled skin to …

Oncolog, Volume 57, Number 02, February 2012, Don Norwood, Bryan Tutt

OncoLog MD Anderson's Report to Physicians (All issues)

• Pediatric and Adult Cancer Patients Face Different Issues in Care, Survivorship: The challenges faced by children and adults with cancer can differ markedly, even when they have the same type of cancer
• Palliative Care May Offer Survival Benefits: Recent studies indicate that palliative care, which has been shown to improve quality of life in patients with advanced cancer, may also help patients live longer
• INBRIEF: Targeted Therapy Causes Chronic Lymphocytic Leukemia Remission/Study Finds Acupuncture Can Prevent Radiation-Induced Chronic Dry Mouth
• HOUSE CALL: Understanding the risks, benefits, and purpose of a trial can help cancer patients decide whether to participate

2012 Cancer Care Annual Report, Children's Mercy Hospital

Cancer Center Annual Reports

Annual report of cancer care and oncology services at the Children's Mercy Hospital, Kansas City MO, a pediatric medical center.

Oncolog, Volume 57, Number 01, January 2012, Joe Munch, Sunni Hosemann

OncoLog MD Anderson's Report to Physicians (All issues)

• Meeting Needs of Cancer Survivors: Thanks to new treatments and early detection, many types of cancer can be cured or managed, and more cancer patients are surviving than in the past. These long-term survivors have unique health care needs that are just beginning to be understood.
• Compass: Locally Advanced Squamous Cell carcinoma of the Tonsil- Advances in surgical techniques may broaden treatment options for some patients.
• HOUSE CALL: Sex after Cancer Treatment- Many cancer-related sexual problems can be solved