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Full-Text Articles in Medicine and Health Sciences
Intraoperative Opioid Administration Among Cancer Patients, Amanda Barrett, Kenn B Daratha
Intraoperative Opioid Administration Among Cancer Patients, Amanda Barrett, Kenn B Daratha
Books, Presentations, Posters, Etc.
Background Cancer prevalence continues to rise. In vitro and in vivo studies have demonstrated that opioid receptor agonists may be associated with poor outcomes for cancer patients. Laboratory studies have shown that opioids cause immunosuppression; tumor cell progression, recurrence and metastasis. The surgical environment further decreases immune function, causes an inflammatory response and promotes cancer cell mobilization. Anesthesia providers are in a unique position to influence postoperative outcomes. Opioid free anesthetic delivery is a growing trend amongst anesthesia providers and is supported by the literature. The purpose of this project is to compare intraoperative opioid administration rates for patients with …
Staying Well With Survivorship Wellness, Janni Buaiz
Staying Well With Survivorship Wellness, Janni Buaiz
Books, Presentations, Posters, Etc.
No abstract provided.
Conversations Matter: Initiating A Serious Illness Conversation, Matthew J Gonzales, Suzanne Engelder
Conversations Matter: Initiating A Serious Illness Conversation, Matthew J Gonzales, Suzanne Engelder
Books, Presentations, Posters, Etc.
No abstract provided.
Oncology Navigation: Improving The Patient Experience, Rhonda Hjelm
Oncology Navigation: Improving The Patient Experience, Rhonda Hjelm
Books, Presentations, Posters, Etc.
No abstract provided.
What's New In Ovarian Cancer, Jessica L. Kozuki
What's New In Ovarian Cancer, Jessica L. Kozuki
Books, Presentations, Posters, Etc.
No abstract provided.
Cologuard: Stool Dna Testing For Colorectal Cancer Screening, Grace Hwang
Cologuard: Stool Dna Testing For Colorectal Cancer Screening, Grace Hwang
Books, Presentations, Posters, Etc.
No abstract provided.
“-Itis & -Itis”: Immune Checkpoint Inhibitors Toxicity Management, Timothy E. Byun
“-Itis & -Itis”: Immune Checkpoint Inhibitors Toxicity Management, Timothy E. Byun
Books, Presentations, Posters, Etc.
No abstract provided.
Renal Considerations In The Oncology Patient, Sridhar K. Reddy
Renal Considerations In The Oncology Patient, Sridhar K. Reddy
Books, Presentations, Posters, Etc.
No abstract provided.
Mild Cognitive Deficits From Cancer Treatments, Jason Tse
Mild Cognitive Deficits From Cancer Treatments, Jason Tse
Books, Presentations, Posters, Etc.
No abstract provided.
Advances In Radiation Oncology, Robert Ash
Advances In Radiation Oncology, Robert Ash
Books, Presentations, Posters, Etc.
No abstract provided.
Perilymphatic Irx-2 Cytokine Therapy To Enhance Tumor Infiltrating Lymphocytes And Pd-L1 Expression Preceding Curative-Intent Therapy In Early Stage Breast Cancer, Joanna Pucilowska, Venkatesh Rajamanickam, Katherine Sanchez, Valerie Conrad, Alison Conlin, Shagheyegh Aliabadi-Wahle, Shu-Ching Chang, Gary Grunkemeier, Nikki Moxon, Staci Mellinger, Maritza Martel, James Egan, Monil Shah, David B Page
Perilymphatic Irx-2 Cytokine Therapy To Enhance Tumor Infiltrating Lymphocytes And Pd-L1 Expression Preceding Curative-Intent Therapy In Early Stage Breast Cancer, Joanna Pucilowska, Venkatesh Rajamanickam, Katherine Sanchez, Valerie Conrad, Alison Conlin, Shagheyegh Aliabadi-Wahle, Shu-Ching Chang, Gary Grunkemeier, Nikki Moxon, Staci Mellinger, Maritza Martel, James Egan, Monil Shah, David B Page
Books, Presentations, Posters, Etc.
Background: Cytokines are being explored as a therapeutic strategy to modulate the tumor microenvironment and facilitate immunotherapy benefit in breast cancer. Here, we investigate a locoregional therapeutic approach whereby cytokines (IRX-2) are administered into the subcutaneous peri-areolar tissue (in an anatomic distribution similar to sentinel lymph node mapping) to facilitate immune cell recruitment/activation within the draining lymph nodes and tumor in ESBC. IRX-2 is derived from ex vivo phytohemagglutinin-stimulated lymphocytes and contains multiple cytokines including IL-1β, IL-2, TNF-α, IFN-γ, IL-6, IL-8, and GM-CSF, with stable concentrations from lot to lot. Preclinically, IRX-2 activates T-cells and natural killer (NK) cells, facilitates …
Updated Efficacy Of First Or Second-Line Pembrolizumab Plus In Metastatic Triple Negative Breast Cancer And Correlations With Baseline Lymphocyte And Naïve Cd4+ T-Cell Count, David Page, Joanna Pucilowska, Laura Bennetts, I Kim, Katherine Sanchez, Maritza Martel, Alison Conlin, Nikki Moxon, Staci Mellinger, Anupama Acheson, K Kemmer, Z Mitri, J Vuky, J Ahn, C Abaya, T Manigault, R Basho, Walter Urba, Hl Mcarthur
Updated Efficacy Of First Or Second-Line Pembrolizumab Plus In Metastatic Triple Negative Breast Cancer And Correlations With Baseline Lymphocyte And Naïve Cd4+ T-Cell Count, David Page, Joanna Pucilowska, Laura Bennetts, I Kim, Katherine Sanchez, Maritza Martel, Alison Conlin, Nikki Moxon, Staci Mellinger, Anupama Acheson, K Kemmer, Z Mitri, J Vuky, J Ahn, C Abaya, T Manigault, R Basho, Walter Urba, Hl Mcarthur
Books, Presentations, Posters, Etc.
Background: In mTNBC, anti-PD-1/L1 monotherapy is most effective when administered early in the course of disease, with recent trials demonstrating overall response rates (ORR) of 23-26% in the first-line setting and 5-6% in later lines. This may reflect iatrogenic lymphopenia from preceding cytotoxic chemotherapy. Furthermore, curative-intent chemotherapy is associated with prolonged suppression of naïve CD4+ cells, a T-cell subset that may play a critical role in the generation of de novo anti-tumor immune responses. We present the final clinical results of a pilot study evaluating the safety and efficacy of combining pembrolizumab plus standard-of-care capecitabine in the first/second-line mTNBC …
Intratumoral Delivery Of Mdna55, An Interleukin-4 Receptor Targeted Immunotherapy, By Mri-Guided Convective Delivery For The Treatment Of Recurrent Glioblastoma, Achal Achrol, Manish Aghi, Krystof Bankiewicz, Martin Bexon, Sotirios Bisdas, Steven Brem, Andrew Brenner, Nicholas Butowski, Melissa Coello, Seunggu Jude Han, Santosh Kesari, Fahar Merchant, Dina Randazzo, Diana Roettger, Michael Vogelbaum, Frank Vrionis, Miroslaw Zabek, John Sampson
Intratumoral Delivery Of Mdna55, An Interleukin-4 Receptor Targeted Immunotherapy, By Mri-Guided Convective Delivery For The Treatment Of Recurrent Glioblastoma, Achal Achrol, Manish Aghi, Krystof Bankiewicz, Martin Bexon, Sotirios Bisdas, Steven Brem, Andrew Brenner, Nicholas Butowski, Melissa Coello, Seunggu Jude Han, Santosh Kesari, Fahar Merchant, Dina Randazzo, Diana Roettger, Michael Vogelbaum, Frank Vrionis, Miroslaw Zabek, John Sampson
Books, Presentations, Posters, Etc.
No abstract provided.