Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
P11 Expression And Pet In Bipolar Disorders, Lei Zhang, Cheng-Ta Li, Tung-Ping Su, Xian-Zhang Hu, Ruth A. Lanius, Maree J. Webster, Ming-Yi Chung, Ying-Sheue Chen, Ya-Mei Bai, Jeffery L. Barker, James E. Barrett, Xiao-Xia Li, He Li, David M. Benedek, Robert Ursano
P11 Expression And Pet In Bipolar Disorders, Lei Zhang, Cheng-Ta Li, Tung-Ping Su, Xian-Zhang Hu, Ruth A. Lanius, Maree J. Webster, Ming-Yi Chung, Ying-Sheue Chen, Ya-Mei Bai, Jeffery L. Barker, James E. Barrett, Xiao-Xia Li, He Li, David M. Benedek, Robert Ursano
Uniformed Services University of the Health Sciences
Background: Bipolar disorder (BD) is a common mental disorder, subdivided into BD-I and BD-II. Currently, few biomarkers differentiate BD-I from BD-II. However, it is suggested that peripheral blood mononuclear cell (PBMC) mRNA levels of p11 and positron emission tomography (PET) might be potential biomarkers for BD.
Methods: Healthy controls (HCs), BD-I, and BD-II patients in remission (n = 20 in each group) underwent a resting PET study with the radiotracer [18F]-2-deoxy-2-fluoro-D-glucose (18F-FDG). PBMC p11 mRNA levels were determined by quantitative real-time PCR.
Results: Comparing BD patients to HCs, normalized glucose metabolism (NGM) was higher …