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Shiga And Shiga-Like Toxins, Alison D. O'Brien, Randall K. Holmes
Shiga And Shiga-Like Toxins, Alison D. O'Brien, Randall K. Holmes
Uniformed Services University of the Health Sciences
Introduction ........................ 206
Shiga Toxin in Shigella Spp. ........................ 207
History ........................ 207
Purification and Structure ........................ 207
Mode of Action ........................ 208
Receptor binding and internalization ........................ 208
Inhibition of protein synthesis ........................ 209
Immunology and Immunochemistry ........................ 209
Genetics ........................ 210
Role of Toxin in Disease ........................ 210
Dysentery ........................ 210
Diarrhea ........................210
HUS ........................ 211
Shiga-like toxins in E. Coli ........................ 211
History and Nomenclature ........................ 211
Discovery that EPEC and EHEC make Shiga-like toxins ........................ 211
Relationship of Shiga-like toxins to Vero toxins ........................ 212
Purification and Structure ........................ 212
Mode of Action ........................ 212
Immunology …