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Articles 1 - 30 of 185
Full-Text Articles in Medicine and Health Sciences
Predictive Values Of Mallampati Score, Tonsillar Size, And Bmi Z-Score In The Presence And Severity Of Obstructive Sleep Apnea In Pediatric Population, Ayşe Kaçar Bayram, Ahu Paketçi̇, Melek Nur Şahbaz, Sevde Daşdelen, Serkan Bilge Koca
Predictive Values Of Mallampati Score, Tonsillar Size, And Bmi Z-Score In The Presence And Severity Of Obstructive Sleep Apnea In Pediatric Population, Ayşe Kaçar Bayram, Ahu Paketçi̇, Melek Nur Şahbaz, Sevde Daşdelen, Serkan Bilge Koca
Turkish Journal of Medical Sciences
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder in children. Determination of riskfactors for the development of OSA is essential for early diagnosis and treatment of the disease and decreases the risk of negativeconsequences. This study aimed to investigate the predictive values of Mallampati score, tonsillar size, and BMI z-score in the presenceand severity of OSA in children.Materials and methods: This prospective cross-sectional study included 114 children with OSA symptoms. All children were assessedby BMI z-score, Mallampati score, and tonsillar size and underwent overnight polysomnography. They were consecutively selected andassigned to 4 groups as follows: Group 1 included …
Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ
Adjunctive Use Of Laser Biostimulation With Nonsurgical Periodontal Therapy: A Split Mouth, Randomized, Case-Control Study In Diabetic And Nondiabetic Periodontitispatients, Funda Akansel, Umur Sakallioğlu, Müge Lütfi̇oğlu, Feyza Otan Özden, Adil Karadağ
Turkish Journal of Medical Sciences
Laser biostimulation therapy (LBT) is suggested to have positive effects on periodontal healing. This study evaluatedLBT with nonsurgical periodontal therapy (NSPT) in diabetes mellitus (DM) and systemic health (SH) conditions.Materials and methods: Thirty periodontitis patients (15 with DM and 15 with SH) were included in the study, which had a split-mouthdesign, by applying LBT in the mouth of the same systemic condition. Thus, 4 study groups were formed, as 1) NSPT – DM: NSPT alonein DM, 2) NSPT + LBT – DM: NSPT + LBT application in DM, 3) NSPT – SH: NSPT alone in SH, and 4) NSPT + …
The Role Of Probiotics For Preventing Dysbiosis In Periodontal Disease: A Randomized Controlled Trial, Tuğba Şahi̇n, Gülçin Akca, Nurdan Özmeri̇ç
The Role Of Probiotics For Preventing Dysbiosis In Periodontal Disease: A Randomized Controlled Trial, Tuğba Şahi̇n, Gülçin Akca, Nurdan Özmeri̇ç
Turkish Journal of Medical Sciences
Scaling and root planing remain inadequate in periodontitis treatment caused by dysbiotic microbial dental plaque. The aim of this clinical trial is to evaluate the effects of probiotics and kefir consumption in initial periodontal therapy (IPT) on oral microbiota composition and treatment outcomes in patients with periodontitis.Materials and methods: The study was carried out in the Gazi University Department of Periodontology, including a sample size of 36 individuals and utilizing a randomized controlled design. Thirty-six patients with periodontitis were randomly allocated to three groups: one receiving probiotic treatment, another receiving kefir, and a third serving as the control group. Obtaining …
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Evaluation Of The Cytotoxic Effect Of Titanium Dioxide Nanoparticles In Human Embryonic Lung Cells, Olkan Afşar, Çağatay Oltulu
Turkish Journal of Medical Sciences
Background/aim: Titanium dioxide nanoparticles are widely used in a variety of products, including sunscreens, paints, and ceramics. However, their increasing use has raised concerns about their potential health risks. Titanium dioxide nanoparticles have been shown to have the ability to enter the bloodstream and accumulate in various tissues, reaching the fetus via the placenta. The aim of this study was to investigate the cytotoxic effects of titanium dioxide nanoparticles on a human embryonic lung cell line (HEL 299/An1) and the formation of oxidative DNA damage. Materials and methods: The cytotoxic effects of brookite-based titanium dioxide nanoparticles (<100 nm) were assessed using the 3-(4,5-dimethyldiazol-2-yl)-2,5 diphenyl tetrazolium bromide (MTT) assay for 24 and 48 h. Cell titanium levels were determined using inductively coupled plasma mass spectrometry. Oxidative DNA damage was assessed by measuring the levels of 8-hydroxy-2- deoxyguanosine (8-OHdG) as a biomarker. Results: Titanium dioxide nanoparticles caused dose-dependent cytotoxicity in HEL 299/An1 cells. The IC50 values were 25.93 μM and 0.054 μM after 24 h and 48 h of exposure, respectively. Cell titanium levels were found to be 25,967 ppb after 24 h and 210,353 ppb after 48 h (p < 0.01). 8-OHdG was detected at 32.96 ng/mL after 24 h of exposure and 17.89 ng/mL after 48 h of exposure. Conclusion: In our study, it was shown that titanium nanoparticles caused dose-dependent cytotoxicity and oxidative DNA damage in human embryonic lung cells. The nanoparticles also accumulated in cells and were taken up in higher amounts after 48 h of exposure. These findings suggest that titanium dioxide nanoparticles may pose a health risk, especially for pregnant women who may not be aware of their pregnancy. Therefore, it is important to take preventive measures to reduce exposure to these nanoparticles.
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
The Evaluation Of Oxidative Stress And Inflammation Markers In Serum And Saliva Of The Patients With Temporomandibular Disorders, Di̇lara Kazan, Burcu Baş, Abdurrahman Aksoy, Enes Atmaca
Turkish Journal of Medical Sciences
Background/aim: Temporomandibular Disorders (TMD), as in the occurrence of many diseases, have been associated with oxidative stress (OS) resulting from the disruption of antioxidant mechanisms and the accumulation of reactive oxygen species in tissues. This study was designed to compare salivary and serum OS and inflammation markers of individuals with TMD and healthy subjects. Materials and methods: A prospective cross-sectional study was conducted. Twenty-seven TMD patients diagnosed with disc displacement (DD) according to Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and 17 healthy subjects were enrolled in the study. Prior to any treatment, serum, and saliva samples were taken from …
Current Developments In Surface Electromyography, Veysel Alcan, Murat Zi̇nnuroğlu
Current Developments In Surface Electromyography, Veysel Alcan, Murat Zi̇nnuroğlu
Turkish Journal of Medical Sciences
Background/aim: Surface electromyography (surface EMG) is a primary technique to detect the electrical activities of muscles through surface electrodes. In recent years, surface EMG applications have grown from conventional fields into new fields. However, there is a gap between the progress in the research of surface EMG and its clinical acceptance, characterized by the translational knowledge and skills in the widespread use of surface EMG among the clinician community. To reduce this gap, it is necessary to translate the updated surface EMG applications and technological advances into clinical research. Therefore, we aimed to present a perspective on recent developments in …
Developmental Characteristics Of Williams-Beuren Syndrome And Evaluation Of Adaptive Behavioral Skills, Şenay Güven Baysal, Feyzullah Necati̇ Arslan, Mehmet Aki̇f Büyükavci, Fatma Hi̇lal Yağin, Cemal Eki̇ci̇, Zeynep Esener, Derya Doğan
Developmental Characteristics Of Williams-Beuren Syndrome And Evaluation Of Adaptive Behavioral Skills, Şenay Güven Baysal, Feyzullah Necati̇ Arslan, Mehmet Aki̇f Büyükavci, Fatma Hi̇lal Yağin, Cemal Eki̇ci̇, Zeynep Esener, Derya Doğan
Turkish Journal of Medical Sciences
Background/aim: Williams-Beuren syndrome (WBS) is a rare genetic disorder with delays in language and cognitive development, but, with increased awareness of clinical features and a reliable diagnostic test, WBS is becoming more widely recognized in childhood. Adaptive behavior skills and/or maladaptive behavior are important for the prognosis of individuals with WBS. The aim of this study was to investigate the clinical and developmental characteristics of patients with WBS and further increase awareness about it by evaluating the adaptive skills and maladaptive behaviors of the patients. Materials and methods: The data of WBS patients followed-up at the Developmental Behavioral Pediatrics Unit …
Unraveling The Impact Of Primary Immunodeficiency Disorders On The Microbiota Of Dental Caries In Children Through 16s Rrna Gene-Based Metagenomic Analysis, Bushra Al-Kebsi̇, Gökhan Kars, Hazal Özer, Şükrü Nai̇l Güner
Unraveling The Impact Of Primary Immunodeficiency Disorders On The Microbiota Of Dental Caries In Children Through 16s Rrna Gene-Based Metagenomic Analysis, Bushra Al-Kebsi̇, Gökhan Kars, Hazal Özer, Şükrü Nai̇l Güner
Turkish Journal of Medical Sciences
Background/aim: Dental caries is a frequently occurring and multifactorial chronic disease in children resulting from the interaction of cariogenic bacteria and host susceptibility. The aim of this study was to elucidate the impacts of primary immunodeficiency disorders (PIDs) on microbiota of dental caries in children by 16S rRNA gene-based metagenomic analysis. Materials and methods: Enrolled in this study were 15 children with primary PID with caries (PID group) and 15 healthy children with caries as a control (CG). The DMFT index, saliva flow rate, and buffering capacity of each participant were assessed before the metagenomic analyses were conducted. For taxonomic …
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Effects Of Thymoquinone And Memantine Alone And In Combination On Memory And Hippocampal Morphology In Rats With Streptozotocin-Induced Alzheimer's Disease, Şeyma Özsoy, Zi̇ya Çakir, Eli̇f Akçay, Fi̇kret Gevrek
Turkish Journal of Medical Sciences
Background/aim: Alzheimer's disease (AD) is a progressive neurodegenerative disease. Thymoquinone (TQ) has broad biological functions, including antiinflammatory, antioxidant, neuroprotective properties. Memantine (MEM) is indicated for the symptomatic treatment of moderate to severe AD. We aimed to evaluate the effect of TQ alone or in combination with MEM on memory and hippocampal morphology in an STZ-induced rat AD model. Materials and methods: Thirty male rats were included in this study. The AD model was created by giving ICV STZ. The rats were divided into 5 groups (n = 6 each). Group 1 (control group): The rats received only ICV-STZ 3 mg/kg …
Early Assessment Of Extremity Compartment Syndrome By Biochemical Markers In A Rat Model, Ahmet Yildirim, İbrahi̇m Özkan Önal, Zeli̇ha Esi̇n Çeli̇k, Hüsametti̇n Vatansev, Esra Paydaş Hataysal
Early Assessment Of Extremity Compartment Syndrome By Biochemical Markers In A Rat Model, Ahmet Yildirim, İbrahi̇m Özkan Önal, Zeli̇ha Esi̇n Çeli̇k, Hüsametti̇n Vatansev, Esra Paydaş Hataysal
Turkish Journal of Medical Sciences
Background/aim: This experimental study aimed to define a biochemical marker that will enable early diagnosis of acute compartment syndrome (ACS) of extremities, a mortal condition that occurs due to trauma. Materials and methods: A total of 15 Wistar rats were included in the study in which saline infusion technique, a clinically compatible ACS model, was applied. After the rats were anesthetized with ketamine-xylazine, the in-compartment pressure of the hind limb was slowly increased with saline delivered through the angiocatheter, and after reaching the target compartment pressure, the pressure level was kept with a rubber tourniquet. The in-compartment pressure level was …
Drug Interaction Potential Of Ankaferd Blood Stopper® In Human Hepatocarcinoma Cells, Asli Semi̇z
Drug Interaction Potential Of Ankaferd Blood Stopper® In Human Hepatocarcinoma Cells, Asli Semi̇z
Turkish Journal of Medical Sciences
Background/aim: Ankaferd blood stopper® (ABS) is an herbal extract consisting of mixtures of Alpinia officinarum, Gycyrrhiza glabra, Vitis vinifera, Thymus vulgaris, and Urtica dioica plants and has been used in recent years in Turkish medicine as a hemostatic agent. Despite its extensive usage, there is no information available about the drug interaction in HepG2 cells. The current work evaluated the effect of ABS on the expression of CYP1A1-1A2, CYP2E1, and CYP3A4 isozymes that are primarily involved in drug and carcinogen metabolism. Materials and methods: We selected HepG2 cells as in vitro cellular models of the human liver. The cells were …
A Prospective Study For An Alternative Probe Site For Pulse Oximetry Measurement In Male Patients With Severe Burn Trauma: Penile Shaft, Yeşi̇m Andiran Şenayli, Gülsen Keski̇n, Mi̇ne Akin, Ati̇lla Şenayli, Rabi̇a Ata, Gökhan Demi̇rtaş, Emrah Şenel
A Prospective Study For An Alternative Probe Site For Pulse Oximetry Measurement In Male Patients With Severe Burn Trauma: Penile Shaft, Yeşi̇m Andiran Şenayli, Gülsen Keski̇n, Mi̇ne Akin, Ati̇lla Şenayli, Rabi̇a Ata, Gökhan Demi̇rtaş, Emrah Şenel
Turkish Journal of Medical Sciences
Background/aim: Authors widely use pulse oximetry in clinical monitoring of heart rate (HR) and peripheral oxygen saturation (SpO2) by attachment to the fingers; however, there can be a need for an alternative attachment site, especially for burned patients. We investigate the availability of a pulse oximeter probe attached to the penile shaft as an alternative site in pediatric male patients if all extremities became unavailable for pulse oximetry measurement due to severe burn and/or trauma. Materials and methods: We designed a prospective comparative study in a training and research hospital. After local ethical committee approval, pediatric male cases eligible for …
The Effects Of Early Short-Term Insulin Treatment Vs. Glimepiride On Beta Cell Function In Newly Diagnosed Type 2 Diabetes With Hba1c Above 9%, Jelena Stojanovic, Marina Andjelic-Jelic, Miljanka Vuksanovic, Milica Marjanovic-Petkovic, Biljana Jojic, Marko Stojanovic, Teodora Beljic-Zivkovic
The Effects Of Early Short-Term Insulin Treatment Vs. Glimepiride On Beta Cell Function In Newly Diagnosed Type 2 Diabetes With Hba1c Above 9%, Jelena Stojanovic, Marina Andjelic-Jelic, Miljanka Vuksanovic, Milica Marjanovic-Petkovic, Biljana Jojic, Marko Stojanovic, Teodora Beljic-Zivkovic
Turkish Journal of Medical Sciences
Background/aim: Type 2 diabetes mellitus (T2D) is a complex metabolic impairment. Beta cell (BC) failure is the most challenging among its pathogenetic mechanisms. Recognizing reversible contributors to BC failure could guide individualized approach to early T2D treatment. The aim of this study was to compare early short-term insulin treatment vs. glimepiride, both added to metformin, on BC function, glycemic and lipid control, during 12-month follow-up. Patients and methods: Eighty newly diagnosed T2D patients, 30-65 years of age, presenting with HbA1c ≥ 9% were enrolled in the study. They were randomly assigned to single-month initial insulin therapy (INS) added to metformin, …
Evaluation Of Anthropometric Measurements And Clinical Tests In The Diagnosis Of Difficult Airway In Patients Undergoing Head And Neck Surgery, Şükrü Mert Başpinar, İlkben Günüşen, Demet Sergi̇n, Asuman Sargin, Saci̇tti̇n Taner Balcioğlu
Evaluation Of Anthropometric Measurements And Clinical Tests In The Diagnosis Of Difficult Airway In Patients Undergoing Head And Neck Surgery, Şükrü Mert Başpinar, İlkben Günüşen, Demet Sergi̇n, Asuman Sargin, Saci̇tti̇n Taner Balcioğlu
Turkish Journal of Medical Sciences
No abstract provided.
Analysis Of The Relationship Between Tuberculosis-Related Mortality And Nitrous Oxide Emission Levels In The World With The Environmental Kuznets Curve Method, Şeri̇fe Torun, Kadi̇r Yilmaz, Şevket Özkaya, Şebnem Yosunkaya, Müşerref Şule Akçay
Analysis Of The Relationship Between Tuberculosis-Related Mortality And Nitrous Oxide Emission Levels In The World With The Environmental Kuznets Curve Method, Şeri̇fe Torun, Kadi̇r Yilmaz, Şevket Özkaya, Şebnem Yosunkaya, Müşerref Şule Akçay
Turkish Journal of Medical Sciences
Background/aim: It was aimed to analyze the relationship between tuberculosis-related mortality and nitrous oxide emission levels in the world with the Environmental Kuznets Curve (EKC) Method. Materials and methods: WHO ICD-10 mortality list data and the World Bank Country Data (WBCD) were used between 1997 and 2017 for 12 countries. Cubic regression analysis was used for EKC Analysis. Results: The difference between male and female deaths between 1996 and 1998 has increased sharply since 1999. Male deaths consistently occurred significantly more than female deaths. There was a significant and negative correlation between Nitrous oxide emissions (% change from 1990) and …
The Survival Outcomes And Prognostic Factors Of Hepatocellular Carcinoma Among Type 2 Diabetes Patients: A Two-Centre Retrospective Cohort Study, Noor Atika Azit, Shahnorbanun Sahran, Voon Meng Leow, Manisekar K. Subramaniam, Suryati Mokhtar, Azmawati Mohammed Nawi
The Survival Outcomes And Prognostic Factors Of Hepatocellular Carcinoma Among Type 2 Diabetes Patients: A Two-Centre Retrospective Cohort Study, Noor Atika Azit, Shahnorbanun Sahran, Voon Meng Leow, Manisekar K. Subramaniam, Suryati Mokhtar, Azmawati Mohammed Nawi
Turkish Journal of Medical Sciences
Background/aim: To determine the survival outcomes and prognostic factors associated with hepatocellular carcinoma (HCC) survival in type 2 diabetes (T2D) patients. Materials and methods: This was a retrospective cohort study involving two hepatobiliary centres from January 1, 2012, to June 30, 2018. Medical records were analysed for sociodemographic, clinical characteristics, laboratory testing, and HCC treatment information. Survival outcomes were examined using the Kaplan?Meier and log-rank test. Prognostic factors were determined using multivariate Cox regression. Results: A total of 212 patients were included in the study. The median survival time was 22 months. The 1-, 3-, and 5-year survival rates were …
Nonscarring Scalp Alopecia: Which Laboratory Analysis Should We Perform On Whom?, Ümran Öner, Necmetti̇n Akdeni̇z
Nonscarring Scalp Alopecia: Which Laboratory Analysis Should We Perform On Whom?, Ümran Öner, Necmetti̇n Akdeni̇z
Turkish Journal of Medical Sciences
Background/aim: Vitamins and minerals are thought to play an essential but not entirely clear role in developing, preventing, and treating nonscarring alopecia. Telogen effluvium, androgenetic alopecia, and alopecia areata are the most common forms of nonscarring alopecias. We would like to present a different perspective on laboratory abnormalities in patients with nonscarring alopecia. Materials and methods: A total of 467 patients (287 females, 180 males) were included retrospectively: One hundred and sixty patients in the telogen effluvium group, 101 patients in the androgenetic alopecia group, 99 patients in the alopecia areata group, and 107 patients in the hair loss group …
A Comparison Of Angled (D-Blade) And Macintosh (C-Mac) Videolaryngoscopes For Simulated Pediatric Difficult Airway: A Randomized Single-Blind Study, Alparslan Kuş, Can Aksu, Hadi̇ Ufuk Yörükoğlu, Volkan Alparslan, Kami̇l Toker
A Comparison Of Angled (D-Blade) And Macintosh (C-Mac) Videolaryngoscopes For Simulated Pediatric Difficult Airway: A Randomized Single-Blind Study, Alparslan Kuş, Can Aksu, Hadi̇ Ufuk Yörükoğlu, Volkan Alparslan, Kami̇l Toker
Turkish Journal of Medical Sciences
Background/aim: Being prepared for difficult airway (DA) is nevertheless of great importance. Failed or delayed tracheal intubation (TI) can increase morbidity and mortality, and the pediatric population is more prone to hypoxia. With the development of different types of videolaryngoscope (VL), these have become the device of choice in patients with DA. Our primary aim was to compare intubation times with D-blade and Macintosh blade of Storz C-MAC® in a simulated pediatric DA scenario with this randomized controlled trial. Materials and methods: Children aged 1-5 years scheduled for elective surgery were included in the study. Patients were randomized into two …
Striatal Dopaminergic Neurons As A Potential Target For Gdnf Based Ischemic Stroke Therapy, Mustafa Çağlar Beker, Merve Beker, Ahmet Burak Çağlayan, Busenur Bolat, Ülkan Kiliç, Gamze Köse, Ertuğrul Kiliç
Striatal Dopaminergic Neurons As A Potential Target For Gdnf Based Ischemic Stroke Therapy, Mustafa Çağlar Beker, Merve Beker, Ahmet Burak Çağlayan, Busenur Bolat, Ülkan Kiliç, Gamze Köse, Ertuğrul Kiliç
Turkish Journal of Medical Sciences
Background/aim: Glial cell-line-derived neurotrophic factor (GDNF) is a well-known regulatory neurotrophic factor on dopaminergic neurons. Several pathologies have been documented so far in case of any impairment in the dopaminergic system. This study aimed to investigate the potential protective role of lentiviral GNDF delivery on the small population of tyrosine hydroxylase (TH) positive dopamine producing striatal neurons after ischemic stroke. Materials and methods: Fourteen C57BL/6J male mice (8-10 weeks) were intracerebrally treated with lentiviral GDNF (Lv-GDNF) or vehicle. Ten days after injections, cerebral ischemia was induced by blockage of the middle cerebral artery. Animals were terminated 72 h after ischemia, …
Antimicrobial Activities Of Ankaferd Bloodstopper, Hypochlorous Acid, And Chlorhexidine Against Specific Organisms, Ahmet Koluman, Alper Aktaş, Selen Adi̇loğlu
Antimicrobial Activities Of Ankaferd Bloodstopper, Hypochlorous Acid, And Chlorhexidine Against Specific Organisms, Ahmet Koluman, Alper Aktaş, Selen Adi̇loğlu
Turkish Journal of Medical Sciences
No abstract provided.
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Dental And Temporomandibular Joint Alterations In Rheumatoid Arthritis Patients Andtheir Association With Salivary Oxidative Stress, Deni̇z Yaman, Duygu Göller Bulut, Gülbahar Ustaoğlu, Emre Avci, Murat Taşçi
Turkish Journal of Medical Sciences
Background/aim: Rheumatoid arthritis (RA) is the most extensive inflammatory arthritis causing permanent deformities in the joint. Increasing evidence suggests that oxidative stress is a substantial factor in the pathogenesis of RA. This study aimed to examine the salivary oxidant-antioxidant status of RA and control groups and to compare these biomarkers by correlating them with disease activity, acute phase reactants, and clinical findings. Materials and methods: Age and sex-matched 60 participants including 30 patients with RA and 30 control (50 females, 10 males; mean age: 42.62 ± 10.89 years) were evaluated. RA disease activity and severity were evaluated by the disease …
1,25-Dihydroxyvitamin D3 Regulates T Helper And B Lymphocyte Responsessubstantially In Drug-Naive Primary Sjögren's Syndrome Patients' Mononuclear Cells, Deni̇z Genç, Merve Sezer Kürkçü, Burcu Günaydin, Emi̇ne Fi̇gen Tarhan
1,25-Dihydroxyvitamin D3 Regulates T Helper And B Lymphocyte Responsessubstantially In Drug-Naive Primary Sjögren's Syndrome Patients' Mononuclear Cells, Deni̇z Genç, Merve Sezer Kürkçü, Burcu Günaydin, Emi̇ne Fi̇gen Tarhan
Turkish Journal of Medical Sciences
Background/aim: A correlation between vitamin D deficiency and primary Sjögren's syndrome (pSS) has already been described. The limited data has been reported regarding the pathological relevance of vitamin D in primary Sjögren's syndrome. In this study, the peripheral blood mononuclear cells were cocultured with 1,25-dihydroxyvitamin D3 to determine the modulatory effect of vitamin D3 on T and B lymphocyte phenotypes in pSS. Materials and methods: Venous blood samples were collected from 11 patients in the treatment phase and 9 drug-naive pSS patients. Peripheral blood mononuclear cells (PBMC) were isolated and separately cultured in the presence and absence of 1,25- dihydroxyvitamin …
Translation And Validation Of A Turkish Version Of The Xerostomia Inventory Xi Inpatients With Primary Sjögren's Syndrome, Bi̇lge Başakci Çalik, Eli̇f Gür Kabul, Ayli̇n Keski̇n, Si̇nem Bozcuk, Hande Şenol, Veli̇ Çobankara
Translation And Validation Of A Turkish Version Of The Xerostomia Inventory Xi Inpatients With Primary Sjögren's Syndrome, Bi̇lge Başakci Çalik, Eli̇f Gür Kabul, Ayli̇n Keski̇n, Si̇nem Bozcuk, Hande Şenol, Veli̇ Çobankara
Turkish Journal of Medical Sciences
Background/aim: The aim of this study was to assess the reliability and validity of Turkish version of the Xerostomia Inventory XI in patients with primary Sjögren's syndrome (pSS). Materials and methods: A cross-sectional survey study design and analysis were used to assess the reliability and validity of the Xerostomia Inventory XI. A total of 69 patients with pSS (5 males, 64 females; mean age = 54.81 ± 8.77 years) were included. The Xerostomia Inventory XI (TR) was applied twice at an interval of 15 days. The test-retest reliability was assessed with the intraclass correlation coefficient (ICC), and the internal consistency …
Clinical Trials Of 3d Printing Splints To Avoid Contracture Development In Burned Children, Ati̇lla Şenayli, Güven Çankaya, Can İhsan Öztorun, Hakan Oflaz, Emrah Şenel
Clinical Trials Of 3d Printing Splints To Avoid Contracture Development In Burned Children, Ati̇lla Şenayli, Güven Çankaya, Can İhsan Öztorun, Hakan Oflaz, Emrah Şenel
Turkish Journal of Medical Sciences
Background/aim: We evaluated the feasibility of producing splints with 3D printer technology to prevent contractures in burned children in our clinical prospective study. Materials and methods: After approvals, children with burns greater than 2nd degree were included in the study. Age, sex, burn percentages, printing time, filament types, number of filament trials, splint suitability, patient and doctor comments, preclinical trials' significances and financial impact were evaluated statistically. Results: Seventy-six trials were conducted on 18 patients. Fourteen of the patients were male and 4 are female. Average ages of boys and girls were 5 and 3, respectively. Burn percentage was 36.9 …
Allergic Diseases In The Elderly Population: A Single-Center Experience, Eray Yildiz, Fati̇h Çölkesen, Şevket Arslan, Recep Evcen, Fi̇li̇z Sadi̇ Aykan, Mehmet Kilinç, Gökhan Ayteki̇n
Allergic Diseases In The Elderly Population: A Single-Center Experience, Eray Yildiz, Fati̇h Çölkesen, Şevket Arslan, Recep Evcen, Fi̇li̇z Sadi̇ Aykan, Mehmet Kilinç, Gökhan Ayteki̇n
Turkish Journal of Medical Sciences
Background/aim: Although allergic diseases are generally considered to be diseases of childhood and youth, the first symptoms of allergic diseases can be seen in old age sometimes. The aim of this study was to determine the prevalence and characteristics of allergic diseases in the elderly population admitted to the allergy unit on an outpatient basis. Materials and methods: The files of the patients who applied to our clinic's allergy unit during the 8-year period were retrospectively analyzed. The data of patients aged ≥ 65 years were obtained from the files of our allergy unit archive. Results: A total of 1272 …
Three-Dimensional Assessment Of Pharyngeal Airway In Individuals With Myotonicdystrophy Type 1, Burcu Evli̇ce, Ayşe Fi̇li̇z Koç, Hazal Duyan, Damla Soydan Çabuk
Three-Dimensional Assessment Of Pharyngeal Airway In Individuals With Myotonicdystrophy Type 1, Burcu Evli̇ce, Ayşe Fi̇li̇z Koç, Hazal Duyan, Damla Soydan Çabuk
Turkish Journal of Medical Sciences
Background/aim: The objectives of this study were to assess pharyngeal airway volume (PAV) in patients with myotonic dystrophy type 1 (DM1) by cone-beam computerized tomography (CBCT) and to evaluate the impact of diaphragm thickness and pulmonary function tests on PAV. Materials and methods: Thirty DM1 patients (10 female and 20 male; mean age 42.40 ± 12.07) were included in the study. Age and sex-matched thirty patients were participated as control group. In DM1 group pulmonary function tests (PFT) were performed. Independent t-test was used to compare PAV values of patients with DM1 and control group. The Mann-Whitney U test was …
Evaluation Of The Effects Of Locally Applied Rosuvastatin On Bone Formation In A Threedimensional Reconstruction Rabbit Xenograft Model, Taha Özer, Alper Aktaş, Canseda Avağ, Ayşegül Firat, Mert Ocak, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k
Evaluation Of The Effects Of Locally Applied Rosuvastatin On Bone Formation In A Threedimensional Reconstruction Rabbit Xenograft Model, Taha Özer, Alper Aktaş, Canseda Avağ, Ayşegül Firat, Mert Ocak, Fevzi̇ye Fi̇gen Kaymaz, Hakan Hamdi̇ Çeli̇k
Turkish Journal of Medical Sciences
Background/aim: Guided bone regeneration (GBR) is commonly performed to repair bone defects, and rigid occlusive titanium barriers play a vital role in bone formation in regions with no prior bone tissue. The statin, rosuvastatin (RSV), strongly affects bone apposition when applied locally. Here, we aimed to evaluate the anabolic effects of locally applied RSV with a xenograft placed on rabbit calvaria. Materials and methods: Two rigid occlusive titanium caps were used in 16 rabbits after decorticating the calvarial bone. In the control group, the area under the cap was filled with a xenograft, while in the RSV group, a xenograft …
Evaluation Of Saliva Glutathione, Glutathione Peroxidase, And Malondialdehyde Levels Inhead-Neck Radiotherapy Patients, Gözde Deri̇ndağ, Hayati̇ Murat Akgül, Ahmet Kiziltunç, Hali̇l İbrahi̇m Özkan, Hi̇lal Kiziltunç Özmen, Ni̇lgün Akgül
Evaluation Of Saliva Glutathione, Glutathione Peroxidase, And Malondialdehyde Levels Inhead-Neck Radiotherapy Patients, Gözde Deri̇ndağ, Hayati̇ Murat Akgül, Ahmet Kiziltunç, Hali̇l İbrahi̇m Özkan, Hi̇lal Kiziltunç Özmen, Ni̇lgün Akgül
Turkish Journal of Medical Sciences
Background/aim: It is believed that radiotherapy has important effects on oxidant/antioxidant systems. Oxidative stress occurs when the balance between oxidant formation and antioxidant defense is disrupted in favor of oxidants. The aim of this study was to determine the biochemical changes in saliva pre- and postradiotherapy in head-neck radiotherapy patients and to find out the effects of radiation on glutathione (GSH), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA) levels in saliva. Materials and methods: This study included 16 patients undergoing head-neck radiotherapy in Atatürk University Research Hospital. The levels of GSH, GSH-Px, and MDA were measured in saliva samples taken from …
Assessment And Prevalence Of Concomitant Chemo-Radiotherapy-Induced Oral Mucositisin Patients With Oral Squamous Cell Carcinoma, Sadia Minhas, Aneequa Sajjad, Rabia Chaudhry, Hamza Zahid, Azfar Shahid, Muhammad Kashif
Assessment And Prevalence Of Concomitant Chemo-Radiotherapy-Induced Oral Mucositisin Patients With Oral Squamous Cell Carcinoma, Sadia Minhas, Aneequa Sajjad, Rabia Chaudhry, Hamza Zahid, Azfar Shahid, Muhammad Kashif
Turkish Journal of Medical Sciences
Background/aim: Quantification of oral mucositis that progresses during concomitant chemo-radiotherapy (CCRT) is essential for its management. It is important to determine the methods that are simple, reliable and beneficial in foreseeing mucositis at earlier stages of treatment. Materials and methods: A prospective study was conducted on 100 oral cancer patients receiving CCRT following the inclusion criteria. Patients were evaluated for mucositis i.e. erythema and ulcers by using the World Health Organization (WHO) scale and the oral mucositis assessment scale (OMAS), whereas mature and immature cells were identified by exfoliative cytology. Clinical examination and procedure of oral cavity were performed before, …
The Effect Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On The Diabetic Andnondiabetic Gingival Wound Healing: An Experimental Study, Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akin Yi̇ği̇n, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahi̇t Özcan
The Effect Of Caffeic Acid Phenethyl Ester And Ankaferd Blood Stopper On The Diabetic Andnondiabetic Gingival Wound Healing: An Experimental Study, Mehmet Gül, Serkan Dündar, Gökhan Artaş, Akin Yi̇ği̇n, Abdulsamet Tanik, Mehmet Emrah Polat, Erhan Cahi̇t Özcan
Turkish Journal of Medical Sciences
Background/aim: Healthy wound healing is very important for patient comfort. Diabetes is one of the factors that negatively affect wound healing. Ankaferd Blood Stopper (ABS) and caffeic acid phenethyl ester (CAPE) are antiinflammatory and antimicrobial agents and may have positive effects on wound healing. Materials and methods: In this study, 72 male Wistar albino rats were used. Rats; control, CAPE, ABS, diabetes + control, diabetes + ABS and diabetes + CAPE groups were divided into 6 groups. A healthy 36 rats created diabetes using streptozotocin (STZ). A gingival wound was created using a 4-mm punch biopsy in the gingival tissue …