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Full-Text Articles in Medicine and Health Sciences
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Dynamic Thiol-Disulfide Homeostasis As An Oxidative Stress Marker In Ankylosing Spondylitis And Undifferentiated Spondyloarthropathy, Cemaleddi̇n Öztürk, Şükran Erten, Murat Alişik, İsmai̇l Doğan, Güni̇z Yanik Üstüner, Sali̇m Neşeli̇oğlu, Özcan Erel
Turkish Journal of Medical Sciences
Background/aim: Seronegative spondyloarthropathies (SpA) are a group of chronic diseases characterized by axial inflammation, oligoarthritis, and enthesitis. Oxidative stress may contribute to a wide range of rheumatologic diseases, including SpA. This prospective case-control study was designed to compare thiol-disulfide levels as a marker of oxidative stress between SpA patients and healthy controls. Materials and methods: A total of 144 patients diagnosed with undifferentiated spondyloarthropathy (USpA, n = 97) or ankylosing spondylitis (AS, n = 47) were included along with 80 healthy controls. Serum native thiol (NT), total thiol (TT), and disulfide (D) levels were measured using the fully automated Erel …
The Impact Of Smoking On Response To Tumor Necrosis Factor-Α Inhibitor Treatment In Patients With Ankylosing Spondylitis, Handan Yarkan Tuğsal, Gökçe Kenar Artin, Gerçek Can, Sedat Çapar, Berri̇n Zengi̇n, Servet Akar, Hüseyi̇n Edi̇z Dalkiliç, Abdurrahman Soner Şenel, Süleyman Serdar Koca, Berna Göker, Ayten Yazici, Güzi̇de Nevsun İnanç, Hülya Elli̇dokuz, Nurullah Akkoç, Fatoş Önen
The Impact Of Smoking On Response To Tumor Necrosis Factor-Α Inhibitor Treatment In Patients With Ankylosing Spondylitis, Handan Yarkan Tuğsal, Gökçe Kenar Artin, Gerçek Can, Sedat Çapar, Berri̇n Zengi̇n, Servet Akar, Hüseyi̇n Edi̇z Dalkiliç, Abdurrahman Soner Şenel, Süleyman Serdar Koca, Berna Göker, Ayten Yazici, Güzi̇de Nevsun İnanç, Hülya Elli̇dokuz, Nurullah Akkoç, Fatoş Önen
Turkish Journal of Medical Sciences
Background/aim: To investigate the impact of smoking on disease activity, treatment retention, and response in patients with ankylosing spondylitis (AS) treated with their first tumor necrosis factor-α inhibitor (TNFi). Materials and methods: AS patients who started their first TNFi treatment for the active axial disease (BASDAI ≥ 4) from TURKBIO Registry were included. Treatment response of smoker (current and ex-smokers) and nonsmoker (never smoker) patients were primarily evaluated as achievement of BASDAI50 or improvement in BASDAI at least 20 mm at 3 months and 6 months compared to baseline. Results: There were 322 patients with AS (60% male, 59% smoker, …
Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari
Validation And Cross-Cultural Adaptation Of The Turkish Version Of The Revised Leeds Disability Questionnaire In Patients With Ankylosing Spondylitis, Mehmet Özkeski̇n, Fati̇h Özden, Özge Ocaker Aktan, Tuba Demi̇rci̇ Yildirim, İsmai̇l Sari
Turkish Journal of Medical Sciences
Background/aim: The revised Leeds Disability Questionnaire (RLDQ) is a unique assessment tool for patients with ankylosing spondylitis (AS); its comprehensive structure includes posture and neck flexibility parameters. The aim of the study was to determine the psychometric properties of the Turkish RLDQ in patients with AS. Materials and methods: A total of 100 AS patients were enrolled in the study. In the first evaluation, patients filled out the Dougados Functional Index (DFI) and Bath Ankylosing Spondylitis Functional Index (BASFI), Stanford Health Assessment Questionnaire (HAQ) in addition to RLDQ. Then, patients were refilled the revised RLDQ in the second assessment. Results: …
The Relationship Of Serum Visfatin Levels With Clinical Parameters, Flow-Mediateddilation, And Carotid Intima-Media Thickness In Patients With Ankylosing Spondylitis, Rabi̇a Aydoğan Baykara, Adem Küçük, Ayça Tuzcu, Göksel Tuzcu, Erkan Cüre, Ali̇ Uğur Uslu, Ahmet Omma
The Relationship Of Serum Visfatin Levels With Clinical Parameters, Flow-Mediateddilation, And Carotid Intima-Media Thickness In Patients With Ankylosing Spondylitis, Rabi̇a Aydoğan Baykara, Adem Küçük, Ayça Tuzcu, Göksel Tuzcu, Erkan Cüre, Ali̇ Uğur Uslu, Ahmet Omma
Turkish Journal of Medical Sciences
Background/aim: Atherosclerotic heart diseases can occur at an early age in patients with ankylosing spondylitis (AS). Flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) values are reliable markers for early detection of subclinical atherosclerosis in patients with AS. We aimed to investigate the relationship between visfatin levels and indirect markers of subclinical atherosclerosis and endothelial dysfunction in patients with AS. Materials and methods: Forty-two patients diagnosed with AS and 42 age, sex, and body mass index (BMI)-matched controls were included in the study. Visfatin levels, FMD, and cIMT were measured using appropriate methods. Results: Visfatin levels of the patients were …
Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre
Effects Of The Covid-19 Pandemic On Psychology And Disease Activity In Patients Withankylosing Spondylitis And Rheumatoid Arthritis, Şaki̇r Gica, Yasemi̇n Akkubak, Zaki̇re Kübra Aksoy, Adem Küçük, Erkan Cüre
Turkish Journal of Medical Sciences
Background/aim: The COVID-19 outbreak is known to increase stress levels of most patients with chronic diseases. Patients with ankylosing spondylitis (AS) and rheumatoid arthritis (RA) are highly susceptible to environmental stress. In the current study, we aimed to determine how the COVID-19 pandemic psychologically affected patients with chronic progressive diseases such as AS and RA and the effects of these psychological factors on disease activity. Materials and methods: Age and sex-matched patients with AS (n = 80), RA (n = 80), and healthy controls (n = 80) were included in the study. All participants were evaluated with the "Perceived COVID-19 …
A Prospective Clinical Investigation Of The Effects Of Anti-Tnf Alpha Therapy On Exercise Capacity In Patients With Ankylosing Spondylitis, Erhan Çapkin, Seyhan Bi̇lge Keski̇n, Murat Karkucak, Ahmet Ayar
A Prospective Clinical Investigation Of The Effects Of Anti-Tnf Alpha Therapy On Exercise Capacity In Patients With Ankylosing Spondylitis, Erhan Çapkin, Seyhan Bi̇lge Keski̇n, Murat Karkucak, Ahmet Ayar
Turkish Journal of Medical Sciences
The purpose of this study was to investigate possible effects of anti-TNF alpha therapy on cardiorespiratory fitness and physical functional capacity of patients with ankylosing spondylitis (AS). Materials and methods: Twenty-eight AS patients meeting the modified New York criteria with active disease state and an equivalent number of healthy individuals as the control were prospectively enrolled. Physical working capacity and aerobic exercise capacity of the participants were determined by using cardiopulmonary exercise tests, performed before and 4 months after initiation of anti-TNF alpha therapy. Results: The mean age of the patients was 37 ± 9.1 years, and mean duration of …
The Association Of Neuropathic Pain And Disease Activity, Functional Level, And Quality Of Life In Patients With Ankylosing Spondylitis: A Cross-Sectional Study, Duygu Geler Külcü, Sevi̇lay Batibay, Gülcan Öztürk Chatip Chousein Achmet, Ni̇lgün Mesci̇
The Association Of Neuropathic Pain And Disease Activity, Functional Level, And Quality Of Life In Patients With Ankylosing Spondylitis: A Cross-Sectional Study, Duygu Geler Külcü, Sevi̇lay Batibay, Gülcan Öztürk Chatip Chousein Achmet, Ni̇lgün Mesci̇
Turkish Journal of Medical Sciences
Background/aim: Increased neuropathic pain (NP) symptoms are seen in rheumatologic diseases such as bromyalgia, osteoarthritis, and rheumatoid arthritis, but no studies have demonstrated a relationship between ankylosing spondylitis (AS) and NP except for a brain imaging study. e aim of this study was to estimate the presence of NP in patients with AS and to investigate how NP was related to disease activity, functional status, and quality of life. Materials and methods: A total of 100 AS patients (71 males and 29 females; median age: 37 years, range: 18?71 years) were included in the study. Pain (visual analog scale (VAS) …
Relationship Between Kinesiophobia And Pain, Quality Of Life, Functional Status, Disease Activity, Mobility, And Depression In Patients With Ankylosing Spondylitis, Deran Oskay, Zeynep Tuna, İrem Düzgün, Bülent Elbasan, Yavuz Yakut, Abdurrahman Tufan
Relationship Between Kinesiophobia And Pain, Quality Of Life, Functional Status, Disease Activity, Mobility, And Depression In Patients With Ankylosing Spondylitis, Deran Oskay, Zeynep Tuna, İrem Düzgün, Bülent Elbasan, Yavuz Yakut, Abdurrahman Tufan
Turkish Journal of Medical Sciences
Background/aim: Our aim was to investigate the association of kinesiophobia with pain, quality of life, clinical measures, and depression in patients with ankylosing spondylitis (AS). Materials and methods: Patients with AS (n: 163) were enrolled in the study. Kinesiophobia was evaluated with the Tampa Scale of Kinesiophobia (TSK), pain with a visual analog scale (VAS), mobility with Bath Ankylosing Spondylitis Metrology Index (BASMI), disease activity with the Bath AS Disease Activity Index (BASDAI), functional status with the Bath AS Functional Index (BASFI), depression level with Beck's Depression Inventory (BDI), and quality of life with the AS Quality of Life Questionnaire …
Sleep Quality, Sleeping Postures, And Sleeping Equipmentin Patients With Ankylosing Spondylitis, Servet Yolbaş, Ahmet Yildirim, Deccane Düzenci̇, Bariş Gündoğdu, Meti̇n Özgen, Süleyman Serdar Koca
Sleep Quality, Sleeping Postures, And Sleeping Equipmentin Patients With Ankylosing Spondylitis, Servet Yolbaş, Ahmet Yildirim, Deccane Düzenci̇, Bariş Gündoğdu, Meti̇n Özgen, Süleyman Serdar Koca
Turkish Journal of Medical Sciences
Background/aim: Inflammatory back pain, spinal stiffness, and limited spinal mobility are characteristic features of ankylosing spondylitis (AS). Sleeping postures can affect and/or reflect sleeping disturbances. The aim of the study was to evaluate sleeping postures and sleep disturbances in patients with AS. Materials and methods: Seventy-seven patients with AS and 49 healthy controls were enrolled. The Pittsburgh Sleep Quality Index (PSQI) and the Insomnia Severity Index (ISI) were applied to both groups. The most common sleeping postures were noted. Results: There was no significant difference between the groups in terms of sleeping postures. Total PSQI and ISI scores were higher …
Treatment Of Ankylosing Spondylitis, İsmai̇l Sari, Mehmet Aki̇f Öztürk, Nurullah Akkoç
Treatment Of Ankylosing Spondylitis, İsmai̇l Sari, Mehmet Aki̇f Öztürk, Nurullah Akkoç
Turkish Journal of Medical Sciences
No abstract provided.
Anti Tnf-\Alpha Therapy Might Be Responsible For An Increased Incidence Of Varicocele In Patients With Ankylosing Spondylitis, Ömer Yilmaz, Yunus Ugan, Mahmut Yener, Mehmet Umul, Mustafa Kayan, Aykut Recep Aktaş, Eli̇f Ni̇sa Ünlü, Bünyami̇n Kisacik, Bumi̇n Deği̇rmenci̇, Meltem Çeti̇n
Anti Tnf-\Alpha Therapy Might Be Responsible For An Increased Incidence Of Varicocele In Patients With Ankylosing Spondylitis, Ömer Yilmaz, Yunus Ugan, Mahmut Yener, Mehmet Umul, Mustafa Kayan, Aykut Recep Aktaş, Eli̇f Ni̇sa Ünlü, Bünyami̇n Kisacik, Bumi̇n Deği̇rmenci̇, Meltem Çeti̇n
Turkish Journal of Medical Sciences
To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-\alpha) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound. Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-\alpha treatment and patients with AS who were not regularly taking any antiinflammatory drugs. Thirty-one healthy volunteers were included as controls. Results: Left-sided varicocele was determined in 14 patients of Group 1 (44%), 10 patients of Group 2 (33%), and 7 of the controls (23%). There was a statistically significant difference only between Group 1 and controls (P = …
Clinical And Demographic Findings Of Patients With Rheumatoid Arthritis And Ankylosing Spondylitis Treated In A Tertiary Care Center In Turkey, Özlem Cemeroğlu, Zeynep Sila Yaşar, Mustafa Sağlam, Haşi̇m Çakirbay
Clinical And Demographic Findings Of Patients With Rheumatoid Arthritis And Ankylosing Spondylitis Treated In A Tertiary Care Center In Turkey, Özlem Cemeroğlu, Zeynep Sila Yaşar, Mustafa Sağlam, Haşi̇m Çakirbay
Turkish Journal of Medical Sciences
Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are 2 common rheumatic diseases that are frequent causes of disability. In this descriptive study, demographic, clinical, and laboratory findings of patients with RA and AS being followed in a tertiary care center in Turkey were reported. Materials and methods: The patient data of 45 RA and 45 AS cases were collected retrospectively from electronic medical records. Demographic findings, clinical and laboratory assessments of disease activity, drugs used for the treatment, and effect on quality of life of patients with RA and AS were analyzed. Results: In RA patients, 27% had mild, 44% …
Mefv Mutation Frequency And Effect On Disease Severity In Ankylosing Spondylitis, Yüksel Maraş, Ali̇ Akdoğan, Bünyami̇n Kisacik, Levent Kiliç, Engi̇n Yilmaz, Abdurrahman Tufan, Umut Kalyoncu, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Meral Çalgüneri̇
Mefv Mutation Frequency And Effect On Disease Severity In Ankylosing Spondylitis, Yüksel Maraş, Ali̇ Akdoğan, Bünyami̇n Kisacik, Levent Kiliç, Engi̇n Yilmaz, Abdurrahman Tufan, Umut Kalyoncu, Şazi̇ye Şule Apraş Bi̇lgen, Sedat Ki̇raz, Ali̇ İhsan Ertenli̇, Meral Çalgüneri̇
Turkish Journal of Medical Sciences
To define the frequency of familial Mediterranean fever gene (MEFV) mutations in ankylosing spondylitis (AS) and describe different clinical aspects of MEFV mutation carrier and noncarrier AS patients. Materials and methods: In 112 AS patients, Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Bath Ankylosing Spondylitis Functional Index (BASFI) scores were calculated. The frequencies of 12 different MEFV mutations were studied by multiplex polymerase chain reaction/reverse hybridization method and were compared to those of previously studied healthy controls for 5 common MEFV mutations. Results: MEFV mutations were identified in 46 of 224 (20%) alleles and in 39 (35%) of AS …
Difficulties And Failure Of Laryngeal Mask Insertion In A Patient With Ankylosing Spondylitis, Gönül Ölmez, Hasan Nazaroğlu, Seher Gündüz Arslan, Mehmet Ali̇ Özyilmaz, Ayşe Di̇cle Turhanoğlu
Difficulties And Failure Of Laryngeal Mask Insertion In A Patient With Ankylosing Spondylitis, Gönül Ölmez, Hasan Nazaroğlu, Seher Gündüz Arslan, Mehmet Ali̇ Özyilmaz, Ayşe Di̇cle Turhanoğlu
Turkish Journal of Medical Sciences
MEZ^1, Hasan NAZAROĞLU^2, Seher Gündüz ARSLAN^3, Mehmet Ali ÖZYILMAZ^1, Ayşe Dicle TURHANOĞLU4 ^1Department of Anesthesiology, Faculty of Medicine, Dicle University, Diyarbakır - Turkey ^2Department of Radiology, Faculty of Medicine, Dicle University, Diyarbakır - Turkey ^3Department of Orthodontics, Faculty of Dentistry, Dicle University, Diyarbakır - Turkey ^4Physical Therapy and Rehabilitation, Faculty of Medicine, Dicle University, Diyarbakır - Turkey