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Full-Text Articles in Medicine and Health Sciences
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Cochlear Pathology In Preeclamptic Rats: Protective Effects Of Vitamin D And Magnesium Sulfate, Mustafa Altintaş, Eni̇s Hi̇di̇şoğlu, Alexandra Cernomorceno, Nuray Ensari̇, Nevreste Di̇dem Sonbay Yilmaz, Özer Erdem Gür, Hülya Eyi̇gör, Züleyha Di̇lek Gülmez, Erdoğan Bulut, Serap Şi̇rvanci, Selahatti̇n Kumru
Turkish Journal of Medical Sciences
Background/aim: This study investigated the possible degeneration in cochlear morphology induced by preeclampsia (PE) and the therapeutic/preventive effect of vitamin D (Vit D) and magnesium sulfate (MgSO4) used separately and together on feto-maternal outcomes. Materials and methods: We created PE in rats using a reduced uterine perfusion pressure (RUPP) animal model and recorded blood pressure (BP), embryonic survival (ES), and embryonic weight (EW) and evaluated cochlear morphology by electron microscopy. Results: The PE group had elevated BP, a decreased number and weight of live pups, and significant degeneration in the cochlea compared to the sham group. In the PEV group, …
Prospective Study Of The Effects Of Isotretinoin And Vitamin D Levels On Severe Acne Vulgaris, Ramadan Hussein, Salman Bindayel, Othman Abahussein
Prospective Study Of The Effects Of Isotretinoin And Vitamin D Levels On Severe Acne Vulgaris, Ramadan Hussein, Salman Bindayel, Othman Abahussein
Turkish Journal of Medical Sciences
Background/aim: Acne vulgaris (AV) is a common inflammatory skin condition associated with psychological and social distress. Its pathogenesis involves factors such as sebaceous hypersecretion and Cutibacterium acnes colonization. Vitamin D plays a crucial role in the pathogenesis of various inflammatory skin disorders, including AV, due to its immunomodulatory effects and involvement in keratinocyte growth and maturity. However, adequate sun exposure is required for optimal vitamin D synthesis. Isotretinoin (IOS), a vitamin A derivative, is a commonly used medication for severe acne, acting by binding to retinoid receptors. It can also form heterodimers with vitamin D receptors, potentially increasing vitamin D …
Serum Vitamin D Levels Are Associated With Acute Postoperative Pain And Opioid Analgesic Consumption After Laparoscopic Cholecystectomy: A Strobe Compliant Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Ahmet Yüksek, Ayşe Yeşi̇m Göçmen, Mehmet Kağan Katar, Mahmut Kiliç, Mehtap Honca
Serum Vitamin D Levels Are Associated With Acute Postoperative Pain And Opioid Analgesic Consumption After Laparoscopic Cholecystectomy: A Strobe Compliant Prospective Observational Study, Ökkeş Hakan Mi̇ni̇ksar, Ahmet Yüksek, Ayşe Yeşi̇m Göçmen, Mehmet Kağan Katar, Mahmut Kiliç, Mehtap Honca
Turkish Journal of Medical Sciences
Background/aim: In this prospective observational study, we aimed to evaluate the relationship between serum levels of vitamin D and acute postoperative pain scores, as well as opioid analgesic consumption in patients undergoing laparoscopic cholecystectomy. Materials and methods: The study was performed in the Medical Faculty Hospital, from April 2020 to April 2021. Postoperative visual analog scale (VAS) pain scores, total tramadol consumption, number of requests on patient-controlled analgesia (PCA) were compared between the vitamin D deficient (≤20 ng/mL; n = 25) and vitamin D nondeficient (>20 ng/mL; n = 55) groups at five time points (T0: in the recovery …