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Articles 1 - 30 of 175
Full-Text Articles in Medicine and Health Sciences
The Effects Of Formaldehyde Intoxication On The Inducible Nitric Oxide Synthase Expression And Nitric Oxide Level In The Liver Tissue Of Rats, Ergün Uçmakli, Ferah Armutcu, Alaatti̇n Öztürk
The Effects Of Formaldehyde Intoxication On The Inducible Nitric Oxide Synthase Expression And Nitric Oxide Level In The Liver Tissue Of Rats, Ergün Uçmakli, Ferah Armutcu, Alaatti̇n Öztürk
Turkish Journal of Medical Sciences
To investigate inductive activity of formaldehyde (FA) on the expression of inducible nitric oxide synthase (iNOS) and level of nitric oxide (NO) in the liver of rats. Materials and methods: Sixteen male Wistar albino rats of the same age (3 months old) were divided into 2 experimental groups, with 8 rats as the control and 8 rats formaldehyde-treated (FAt). The FAt group received intraperitoneal injection of 10 mg/kg FA for 10 days. Activity of iNOS was shown with immunohistochemical stain kits, and the concentration of NO level was measured by spectrophotometric method in the liver tissue. Results: The FAt group …
Does Apnea-Hypopnea Index Alone Reflect Obstructive Sleep Apnea Severity?, Ömer Araz, Di̇dem Pulur, Eli̇f Yilmazel Uçar, Mehmet Meral, Ali̇ Meti̇n Görgüner, Meti̇n Akgün
Does Apnea-Hypopnea Index Alone Reflect Obstructive Sleep Apnea Severity?, Ömer Araz, Di̇dem Pulur, Eli̇f Yilmazel Uçar, Mehmet Meral, Ali̇ Meti̇n Görgüner, Meti̇n Akgün
Turkish Journal of Medical Sciences
We aimed to assess whether there was a correlation between the apnea-hypopnea index (AHI), desaturation time under 90% (DTU-90), and mean saturation (MS) levels and the parameters associated with tissue hypoxia. Materials and methods: A total of 144 subjects were included in the study. Blood C-reactive protein levels, blood uric acid levels, and urine microalbumin levels were measured and the urine uric acid/creatinine ratio and urine microalbumin/creatinine ratio were calculated. Results: Our study results suggest that MS and DTU-90, as well as the AHI, are correlated with the parameters reflecting hypoxemia and the other events secondary to hypoxia. Conclusion: MS …
A Comparison Of Tramadol, Sufentanil, Meperidine, And Lidocaine In Prevention Of Pain Due To Rocuronium Injection, Mehtap Honca, Belkiz Berna Külah, Tarik Purtuloğlu, Tevfi̇k Honca, Nuray Camgöz Eryilmaz, Uğur Özkan, Eyüp Horasanli
A Comparison Of Tramadol, Sufentanil, Meperidine, And Lidocaine In Prevention Of Pain Due To Rocuronium Injection, Mehtap Honca, Belkiz Berna Külah, Tarik Purtuloğlu, Tevfi̇k Honca, Nuray Camgöz Eryilmaz, Uğur Özkan, Eyüp Horasanli
Turkish Journal of Medical Sciences
Alleviation of the pain resulting from injection of rocuronium during anesthesia is still an unsolved problem. We aimed to compare the analgesic effects of sufentanil, tramadol, meperidine, and lidocaine on the pain from injection of rocuronium. Materials and methods: This prospective randomized double-blind study included 200 patients with ASA I-II. After a tourniquet was applied to the forearm, patients received 50 mg of tramadol (group T), 10 µg of sufentanil (group S), 40 mg of meperidine (group M), or 30 mg of lidocaine (group L). The tourniquet was released after 20 s and rocuronium was injected over 10 to 15 …
Investigations Of Als1 And Hwp1 Genes In Clinical Isolates Of Candida Albicans, Melek İnci̇, Mustafa Altay Atalay, Burçi̇n Özer, Ömer Evi̇rgen, Ni̇zami̇ Duran, Vi̇cdan Köksaldi Motor, Ayşe Nedret Koç, Yüsüf Önlen, Çeti̇n Kilinç, Süleyman Durmaz
Investigations Of Als1 And Hwp1 Genes In Clinical Isolates Of Candida Albicans, Melek İnci̇, Mustafa Altay Atalay, Burçi̇n Özer, Ömer Evi̇rgen, Ni̇zami̇ Duran, Vi̇cdan Köksaldi Motor, Ayşe Nedret Koç, Yüsüf Önlen, Çeti̇n Kilinç, Süleyman Durmaz
Turkish Journal of Medical Sciences
To explore the presence of ALS1 and HWP1 genes by multiplex polymerase chain reaction (PCR) in Candida albicans strains. Materials and methods: By using the multiplex PCR method, the presence of agglutinin-like sequence 1 (ALS1) and hyphal wall protein 1 (HWP1) genes were investigated in 206 C. albicans strains that were isolated from various clinical samples. Phenotypic identification of slime formation by microplate and tube adherence tests was performed. Results: The presence of the ALS1 gene was detected in 53.9% of all strains, while the HWP1 gene was present in 5.3%. Slime formation was phenotypically detected in the 62.2% of …
Effectiveness Of Hp-Hmg Versus R-Fsh In Patients Undergoing Ivf/Icsi Cycles With Moderate Male-Factor Infertility, Ni̇lgün Turhan, Aslihan Pekel, Ayli̇n Ayrim, Burcu Kasap, Ömer Bayrak
Effectiveness Of Hp-Hmg Versus R-Fsh In Patients Undergoing Ivf/Icsi Cycles With Moderate Male-Factor Infertility, Ni̇lgün Turhan, Aslihan Pekel, Ayli̇n Ayrim, Burcu Kasap, Ömer Bayrak
Turkish Journal of Medical Sciences
The aim of this case-control study was to compare the efficacy of highly purified human menopausal gonadotropin (HP-hMG) versus recombinant follicle stimulating hormone (r-FSH) treatments following gonadotropin-releasing hormone (GnRH) agonist suppression in patients undergoing intracytoplasmic sperm injection (ICSI) with moderate male-factor infertility in terms of oocyte and embryo quality and clinical pregnancy outcomes. Materials and methods: A total of 240 infertile women were treated with HP-hMG (HP-hMG group, n = 120 patients) or r-FSH (r-FSH group, n = 120 patients) following GnRH agonist suppression (long regimen). Inclusion criteria for the study groups were infertility due to moderate oligoasthenoteratospermia with no …
The Role Of Vitamin D Deficiency In Parathyroid Hormone Levels, Alpaslan Kiliçarslan, Alma Cenoli̇ Aslan, Gamze Gezgen
The Role Of Vitamin D Deficiency In Parathyroid Hormone Levels, Alpaslan Kiliçarslan, Alma Cenoli̇ Aslan, Gamze Gezgen
Turkish Journal of Medical Sciences
Vitamin D deficiency is an important cause of secondary hyperparathyroidism. We aimed to investigate the effect of vitamin D levels on parathyroid hormone (PTH) levels. Materials and methods: We retrospectively chose 2226 patients who were admitted to our hospital’s general internal medicine department for various reasons and had both PTH and vitamin D tests on the same day. Results: It was found that 22.3% of the patients had high levels of PTH and 92% of them had secondary hyperparathyroidism. The average vitamin D level was 16.4 ng/mL. The vitamin D levels of 64% of the patients were below 20 ng/mL …
A Multicenter Study Of The Application Of Six Sigma Management In Clinical Rational Drug Use Via Pharmacist Intervention, Lidao Bao, Nan Chen, Tao Shang, Puyan Fang, Zhanping Xu, Wenchang Guo, Yi Wang
A Multicenter Study Of The Application Of Six Sigma Management In Clinical Rational Drug Use Via Pharmacist Intervention, Lidao Bao, Nan Chen, Tao Shang, Puyan Fang, Zhanping Xu, Wenchang Guo, Yi Wang
Turkish Journal of Medical Sciences
The status of outpatient irrational prescription drug use before and after pharmacist interventions in 6 large scale hospitals was investigated to determine the underlying reasons and to promote rational clinical drug use. Materials and methods: The 5-step DMAIC method (define, measure, analyze, improve, control) in Six Sigma management was utilized to investigate irrational drug use in prescriptions. The statistical software package SAS9.1.3 was adopted to analyze the results, determine possible reasons that could lead to irrational drug use, and then intervene accordingly. Statistics before and after the intervention were compared to analyze the function and effect of Six Sigma management …
The Value Of Apparent Diffusion Coefficient Measurements In The Differential Diagnosis Of Vertebral Bone Marrow Lesions, Gülten Taşkin, Lütfi̇ İncesu, Keri̇m Aslan
The Value Of Apparent Diffusion Coefficient Measurements In The Differential Diagnosis Of Vertebral Bone Marrow Lesions, Gülten Taşkin, Lütfi̇ İncesu, Keri̇m Aslan
Turkish Journal of Medical Sciences
To be able to differentiate benign vertebral bone marrow lesions from malign lesions according to apparent diffusion coefficient (ADC) values, enabling quantitative assessment, and to determine the sensitivity and the specificity in differentiating benign and malign lesions according to the optimal cutoff ADC value. Materials and methods: In 99 patients, 133 lesions in total were included in the study, 59 of which were benign (acute vertebral compression fracture depending on osteoporosis or trauma, spondylitis, atypical hemangioma), and 74 malign (malign compression fracture, metastasis). Each of the benign lesions was compared to the malign lesions. In the statistical analysis, normality tests, …
Rapid Identification Of Aeromonas Species In Stool Samples With Chromogenic Media And Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry: An Institutional Experience, Işin Akyar, Si̇mge Can
Rapid Identification Of Aeromonas Species In Stool Samples With Chromogenic Media And Matrix-Assisted Laser Desorption Ionization-Time Of Flight Mass Spectrometry: An Institutional Experience, Işin Akyar, Si̇mge Can
Turkish Journal of Medical Sciences
To evaluate the routine use of chromogenic media together with matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF) in gastrointestinal infections caused by Aeromonas spp. as rapid, practical, cost-effective and reliable methods. Materials and methods: Between August 2007 and March 2012, a total of 13,194 stool specimens of patients were included in the study. The stool samples and the reference strains were inoculated onto Cefsulodin-Irgasan-Novobiocin agar, sheep blood agar, eosin-methylene blue agar, and Hektoen enteric agar media together with CHROMagar Salmonella Plus. All the Salmonella and Aeromonas suspected colonies were identified with an automated system (Phoenix) and MALDI-TOF. Results: …
Does Adma Affect The Oxidant/Antioxidant Balance In Rats?, Hasan Alaçam, Bahatti̇n Avci, Osman Şaliş, Ahmet Di̇lek, Ahmet Kozan, Cuma Mertoğlu, Mehmet Şahi̇n, Ali̇ Okuyucu
Does Adma Affect The Oxidant/Antioxidant Balance In Rats?, Hasan Alaçam, Bahatti̇n Avci, Osman Şaliş, Ahmet Di̇lek, Ahmet Kozan, Cuma Mertoğlu, Mehmet Şahi̇n, Ali̇ Okuyucu
Turkish Journal of Medical Sciences
Asymmetric dimethylarginine (ADMA) is an inhibitor of nitric oxide synthase (NOS). Oxidative stress might be defined as an imbalance between protein oxidation and antioxidants. Our aim was to determine in vivo whether ADMA causes oxidative damage. Materials and methods: Thirty rats were divided into 3 equal groups: a control group, a group administered 1 mg/kg ADMA, and a group administered 2 mg/kg ADMA. ADMA was administered intraperitoneally for 7 days. Malondialdehyde (MDA), protein carbonyl (PC) content, and nitrate+nitrite concentrations were measured with serum samples. Superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) activities were analyzed with plasma samples. Results: A …
The In Vitro Determination Of Genotoxicity In Peripheral Lymphocytes Of Welders Exposed To Fumes From Metal Arc Welding, Ceylan Şener, Hali̇l Erhan Eroğlu
The In Vitro Determination Of Genotoxicity In Peripheral Lymphocytes Of Welders Exposed To Fumes From Metal Arc Welding, Ceylan Şener, Hali̇l Erhan Eroğlu
Turkish Journal of Medical Sciences
Gas metal arc welding is a widely used method in many industrial areas. In this study, the peripheral blood lymphocytes of 23 welders and 25 nonexposed subjects were monitored for genotoxicity. Materials and methods: The blood samples obtained from the subjects were incubated with a culture medium at 37 °C for 72 h. Cytochalasin-B and BrdU were added for micronucleus and replication index. After incubation, the cultures were harvested, stained, and examined. Results: The micronucleus rate (2.165 ± 1.645) of the welders was quite higher than that of those not exposed (1.352 ± 0.978) (P < 0.01). There was a significant difference between micronucleus rates of smoking and nonsmoking subjects. It was found that as the time of exposure to welding fumes increased, so did the micronucleus rates (2.938 ± 1.723) (P < 0.05). A positive correlation was observed between micronucleus frequency and age. The replication index rate (1.026 ± 0.020) of the welders was higher than that of those not exposed (1.019 ± 0.016) (P = 0.01). Conclusion: It is advised that welders who work with gas metal arc welding be instructed and that necessary protective measures be taken because of the risk caused by metal arc welding fumes.
A Case Of Childhood Vaccination Barrier: Migrant And Seasonal Farmworkers, İbrahi̇m Koruk, Zeynep Şi̇mşek, Süda Teki̇n Koruk
A Case Of Childhood Vaccination Barrier: Migrant And Seasonal Farmworkers, İbrahi̇m Koruk, Zeynep Şi̇mşek, Süda Teki̇n Koruk
Turkish Journal of Medical Sciences
The Expanded Program on Immunization has proven to be one of the most effective public health strategies. However, the literature contends that medically disadvantaged groups have been associated with less compliance with vaccination calendars and schedules. The aim of this cross-sectional survey was to investigate the vaccination coverage of the children of migrant and seasonal farmworkers (MSFs) and to identify their specific barriers to vaccination. Materials and methods: A total of 168 children aged 12-23 months were recruited to the study from a primary healthcare center. Data were collected through a structured questionnaire targeting the issues of infant vaccination status, …
Measurement Of The In-Air Output Ratio For High-Energy Photon Beams Used In Radiotherapy, Murugan Appasamy, Sidonia Valas Xavier, Thayalan Kuppusamy, Ramasubrmanian Velayudham
Measurement Of The In-Air Output Ratio For High-Energy Photon Beams Used In Radiotherapy, Murugan Appasamy, Sidonia Valas Xavier, Thayalan Kuppusamy, Ramasubrmanian Velayudham
Turkish Journal of Medical Sciences
To measure the in-air output ratio of a 15-MV photon beam using locally designed miniphantoms. Materials and methods: Columnar and brass miniphantoms were designed locally to accommodate 0.6 cc and 0.13 cc ionization chambers. The in-air output ratio (S_C) was measured for square, rectangular, and wedged fields for 15 MV. The influences of the orientation of the miniphantom, miniphantom material, and chamber volume on S_C and the collimator exchange effect were also studied. Results: The S_C measurements ranged from 0.944 to 1.0321 for the studied field sizes. The orientation of the miniphantom had no influence on S_C for the range …
Asymmetric Dimethylarginine Levels In Allergic Rhinitis And Nasal Polyposis, Mehmet Tosun, Tayfun Apuhan
Asymmetric Dimethylarginine Levels In Allergic Rhinitis And Nasal Polyposis, Mehmet Tosun, Tayfun Apuhan
Turkish Journal of Medical Sciences
Asymmetric dimethylarginine (ADMA) is the major endogenous inhibitor of nitric oxide synthase. We aimed to investigate the ADMA levels in allergic rhinitis (AR) and nasal polyposis (NP). Materials and methods: A total of 29 AR patients, 21 NP patients, and 30 healthy subjects to be used as a control group were enrolled in the study. ADMA was measured in the AR, NP, and control groups with enzyme-linked immunosorbent assay. Any patients or control subjects with coronary artery disease, renal failure, diabetes mellitus, or hypertension were excluded from the study. Results: The mean ADMA serum concentration was 0.52 ± 0.08 µmol/L …
Endovenous Laser Ablation For Saphenous Vein Insufficiency: Long-Term Results, Ömer Etli̇k, Aşkin Ali̇ Korkmaz, Yeşi̇m Üçkurt, Sevi̇m İndelen, Recep Gündoğdu, Alaatti̇n Öztürk, Sali̇h Alsalehi̇, Soe Moe Aung
Endovenous Laser Ablation For Saphenous Vein Insufficiency: Long-Term Results, Ömer Etli̇k, Aşkin Ali̇ Korkmaz, Yeşi̇m Üçkurt, Sevi̇m İndelen, Recep Gündoğdu, Alaatti̇n Öztürk, Sali̇h Alsalehi̇, Soe Moe Aung
Turkish Journal of Medical Sciences
To present the long-term results of our 158 endovenous laser ablation (EVLA) procedures. Materials and methods: From June 2008 to December 2011, 158 patients (89 women, 69 men; mean age: 38.2 years, range: 27-65) were treated with EVLA for venous insufficiency in 192 lower limbs. All patients were symptomatic and the majority had a class 4 or higher clinical disease (CEAP classification). A 980-nm diode laser was used under general anesthesia combined with local tumescent anesthesia to deliver 100 to 140 laser applications along the course of the vein. Compression bandages were applied for 2 weeks postoperatively. Follow-up exams were …
The Assessment Of Accessory Mental Foramina Using Cone-Beam Computed Tomography, Mustafa Göregen, Özkan Mi̇loğlu, İbrahi̇m Ersoy, İbrahi̇m Şevki̇ Bayrakdar, Hayati̇ Murat Akgül
The Assessment Of Accessory Mental Foramina Using Cone-Beam Computed Tomography, Mustafa Göregen, Özkan Mi̇loğlu, İbrahi̇m Ersoy, İbrahi̇m Şevki̇ Bayrakdar, Hayati̇ Murat Akgül
Turkish Journal of Medical Sciences
The aim of the present study is to assess accessory mental foramina (AMFs) in a Turkish population using cone-beam computed tomography (CBCT). Materials and methods: The CBCT records of 315 patients (196 males and 119 females) were retrospectively analyzed. The differences in AMF incidence by sex, age, side, and location were evaluated using chi-square tests. The distances between the AMF and the mental foramen (MF) and between the AMF and the mandibular canal were measured. Additionally, the relationship between MF size and the presence and absence of the AMF was investigated. Results: AMFs were observed in 6.3% of the patients. …
Comparing Extracorporeal Shock Wave And Hyaluronic Acid In A Rabbit Cartilage Defect Model: The Effects Of Esw On Cartilage Defect, Zekeri̇ya Öztemür, Hati̇ce Özer, Umut Hatay Gölge, Emi̇ne Eli̇f Altuntaş, Okay Bulut
Comparing Extracorporeal Shock Wave And Hyaluronic Acid In A Rabbit Cartilage Defect Model: The Effects Of Esw On Cartilage Defect, Zekeri̇ya Öztemür, Hati̇ce Özer, Umut Hatay Gölge, Emi̇ne Eli̇f Altuntaş, Okay Bulut
Turkish Journal of Medical Sciences
To compare the efficiency of extracorporeal shock wave (ESW) treatment with hyaluronic acid (HA) viscosupplementation in an experimental rabbit cartilage defect model. Materials and methods: A total of 24 New Zealand rabbits were randomly divided into 4 groups: HA, ESW, ESW + HA, and control. Chondral defects were created in the left knees of the rabbits. HA viscosupplementation was performed on the HA and ESW + HA groups, and after 24 h, 0.16 mJ/mm2 ESW was performed on the ESW and ESW + HA groups. After an 8-week follow-up, the rabbits were sacrificed and histopathological examination of the defects was …
Stereological Evaluation Of Ganglion Cells In The Sigmoid Colon In Primary And Recurrent Sigmoid Volvulus, Sabri̇ Selçuk Atamanalp, Cemal Gündoğdu, Deni̇z Ünal, Zekai̇ Halici, Abdullah Kisaoğlu, Bünyami̇ Özoğul
Stereological Evaluation Of Ganglion Cells In The Sigmoid Colon In Primary And Recurrent Sigmoid Volvulus, Sabri̇ Selçuk Atamanalp, Cemal Gündoğdu, Deni̇z Ünal, Zekai̇ Halici, Abdullah Kisaoğlu, Bünyami̇ Özoğul
Turkish Journal of Medical Sciences
To clarify the role of ganglion cells in Auerbach’s plexus of the sigmoid colon in the development and recurrence of sigmoid volvulus (SV). Materials and methods: Pathological block samples of colonic resection materials of 28 patients who underwent sigmoidectomy for SV and, for comparison, samples of 28 patients who underwent sigmoidectomy or low anterior resection for rectosigmoid cancer (RSC) were analyzed using stereological methods. Results: The mean numerical density of ganglion cells was significantly lower in the SV group than in the RSC group (140.70 mm^{-2} and 669.42 mm^{-2}, respectively, P = 0.005), whereas there was no significant difference between …
The Effect Of Preemptive Thoracic Epidural Analgesia On Long-Term Wound Pain Following Major Thoracotomy, Abdullah Can, Ali̇ Fuat Erdem, Yener Aydin, Ali̇ Ahiskalioğlu, Hüsnü Kürşad
The Effect Of Preemptive Thoracic Epidural Analgesia On Long-Term Wound Pain Following Major Thoracotomy, Abdullah Can, Ali̇ Fuat Erdem, Yener Aydin, Ali̇ Ahiskalioğlu, Hüsnü Kürşad
Turkish Journal of Medical Sciences
To evaluate the effects of the performance of preemptive epidural analgesia in major thoracotomies on chronic postthoracotomy pain. Materials and methods: A total of 60 patients with ASA I-II status between the ages of 18 and 75 years who planned to have elective thoracotomy were randomized into 3 groups. In all cases, an epidural catheter was placed at the 6th–7th or 7th–8th thoracic intervals, preoperatively. Patients in the control group (n = 20) did not receive epidural analgesics before and during the operation, and preoperative analgesia was provided by remifentanil infusion. In the incision-sensitized group (n = 20), patients had …
Epidemiology, Clinical Features, And Laboratory Detection Of Mycoplasma Pneumoniae Infection In East Azerbaijan, Iran, Reza Ghotaslou, Simin Sharifi, Mohammad Taghi Akhi, Mohammad Hossein Soroush
Epidemiology, Clinical Features, And Laboratory Detection Of Mycoplasma Pneumoniae Infection In East Azerbaijan, Iran, Reza Ghotaslou, Simin Sharifi, Mohammad Taghi Akhi, Mohammad Hossein Soroush
Turkish Journal of Medical Sciences
Mycoplasma pneumoniae is involved in the etiology of many respiratory tract infections. This prospective study describes the epidemiology and clinical properties of M. pneumoniae infections in hospitals of the Tabriz University of Medical Sciences. Materials and methods: From May 2009 to November 2010, 200 patients with respiratory tract infections were enrolled into this study. Due to antibiotic use 51 patients were excluded. M. pneumoniae from respiratory infections was detected by culture, enzyme-linked immunosorbent assay (ELISA), and polymerase chain reaction (PCR) assays. Results: M. pneumoniae infection was detected in 9 (6.15%), 8 (5.3%), and 3 (2.01%) of patients by PCR, ELISA, …
Incidental Findings On Electron Beam Tomography Renal Angiography In Hypertensive Patients, Baki̇ Heki̇moğlu, Begüm Demi̇rler Şi̇mşi̇r, Mustafa Şeki̇p Altunkan
Incidental Findings On Electron Beam Tomography Renal Angiography In Hypertensive Patients, Baki̇ Heki̇moğlu, Begüm Demi̇rler Şi̇mşi̇r, Mustafa Şeki̇p Altunkan
Turkish Journal of Medical Sciences
To evaluate the prevalence, spectrum, and significance of incidental lesions identified on electron beam tomography (EBT) renal angiography performed to investigate renovascular hypertension. Materials and methods: EBT renal angiography images of 148 cases were evaluated in terms of renal artery variations and renal artery stenosis. Extravascular renal findings, abdominal aorta, iliac artery, liver and gallbladder findings, vertebral lesions, and other intraabdominal organ findings were assessed during the examination. Results: No incidental finding was found in 30 cases (20.2%) in total. The most frequent incidental findings were benign ones without any clinical significance. A total of 13 (8.7%) clinically significant findings …
Antimicrobial Susceptibilities Of Various Arcobacter Species, Ahmet Ünver, Hali̇l İbrahi̇m Atabay, Mi̇tat Şahi̇n, Özgür Çelebi̇
Antimicrobial Susceptibilities Of Various Arcobacter Species, Ahmet Ünver, Hali̇l İbrahi̇m Atabay, Mi̇tat Şahi̇n, Özgür Çelebi̇
Turkish Journal of Medical Sciences
To determine the antimicrobial susceptibilities of various Arcobacter strains isolated from domestic geese, which have great potential for the transmission of arcobacters to humans and animals by contamination of water sources. Materials and methods: A total of 16 Arcobacter strains including A. cryaerophilus (7), A. skirrowii (7), and A. butzleri (2) were examined for their susceptibilities to 20 antibiotics using a disk-diffusion method. Results: All Arcobacter isolates tested were resistant to cloxacillin, cefazolin, optochin, vancomycin, and fusidic acid, and most were susceptible to oxytetracycline, chloramphenicol (except for A. butzleri), nitrofurantoin, amikacin, enrofloxacin, ofloxacin, erythromycin, ampicillin sulbactam, and amoxicillin (except for …
Relationship Between Urolithiasis And Diastolic Functions Of The Heart, Mehmet İnci̇, Bahadir Şarli, Ahmet Çeli̇k, Abdullah Demi̇rtaş, Numan Baydi̇lli̇, Mahmut Akpek, Mehmet Güngör Kaya
Relationship Between Urolithiasis And Diastolic Functions Of The Heart, Mehmet İnci̇, Bahadir Şarli, Ahmet Çeli̇k, Abdullah Demi̇rtaş, Numan Baydi̇lli̇, Mahmut Akpek, Mehmet Güngör Kaya
Turkish Journal of Medical Sciences
Relationships between urolithiasis and cardiovascular disorders were evaluated in several studies. In this study, we aimed to investigate whether urolithiasis causes a decline in cardiac diastolic functions. Materials and methods: Seventy-seven consecutive patients and 40 age- and sex-matched controls were included in this study. Transthoracic echocardiography was performed for all patients. Results: There were 77 patients (mean age: 45 ± 14 years, 64% male) in the stone-formers group and 40 patients (mean age: 43 ± 12 years, 63% male) in the control group. Peak E wave velocity (0.67 ± 0.21 to 0.85 ± 0.18, P = 0.001) and E/A ratio …
Cytokine Associated Neopterin Response Of Peripheral Blood Mononuclear Cells To In Vitro Epstein–Barr Virus Transformation Process Of B Lymphocytes, Lati̇fe Arzu Aral, Ayşegül Atak Yücel
Cytokine Associated Neopterin Response Of Peripheral Blood Mononuclear Cells To In Vitro Epstein–Barr Virus Transformation Process Of B Lymphocytes, Lati̇fe Arzu Aral, Ayşegül Atak Yücel
Turkish Journal of Medical Sciences
The Epstein-Barr Virus (EBV) is a human herpes virus that infects B lymphocytes latently and immortalises the cells due to transformation. EBV infection is asymptomatic in childhood, while it may cause a self-limiting lymphoproliferative disorder in adolescence. This study aimed to show the association between in vitro transformation of B lymphocytes via EBV and the levels of neopterin with different accompanying cytokine responses. Materials and methods: Mononuclear cells were isolated from peripheral blood samples of healthy donors and transformed with an EBV secreting cell-line, B95-8. Neopterin, interferon (IFN)-\gamma, tumour necrosis factor (TNF)-\alpha, and interleukin (IL)-6 levels were measured in culture …
Comparison Of The Protective Effects Of Desflurane And Propofol Anesthesia In Rats: A Hepatic Ischemia-Reperfusion Injury Model, Ayça Taş Tuna, Cengi̇z Beki̇r Demi̇rel, Yusuf Ünal, Aslihan Çavunt Bayraktar, Demet Yilmazer, Mustafa Kavutçu, Murat Alper, Mustafa Kerem
Comparison Of The Protective Effects Of Desflurane And Propofol Anesthesia In Rats: A Hepatic Ischemia-Reperfusion Injury Model, Ayça Taş Tuna, Cengi̇z Beki̇r Demi̇rel, Yusuf Ünal, Aslihan Çavunt Bayraktar, Demet Yilmazer, Mustafa Kavutçu, Murat Alper, Mustafa Kerem
Turkish Journal of Medical Sciences
It is known that desflurane and propofol protect liver tissue via different mechanisms. The aim of this study was to compare the protective effects of these 2 agents against hepatic ischemia-reperfusion injury. Materials and methods: Rats were randomly divided into 2 groups: ischemia and ischemia-reperfusion. Each group was further divided into 3 subgroups: ketamine, desflurane, and propofol. Thirty minutes after anesthetics were administered, the rats were subjected to 45 min of hepatic ischemia and 4 h of reperfusion. Blood samples and liver tissues were obtained in order to assess serum tumor necrosis factor alpha (TNF-\alpha), interleukin-1\beta (IL-1\beta), and malondialdehyde levels …
Renal Bcl-2/Bax Expression In Childhood Henoch-Schönlein Nephritis: Prognostic Importance?, Kenan Bek, Ayşegül Oksal, Gülay Demi̇rci̇n, Mehmet Bülbül, Özlem Aydoğ, Ali̇ Deli̇baş, Ayşe Öner
Renal Bcl-2/Bax Expression In Childhood Henoch-Schönlein Nephritis: Prognostic Importance?, Kenan Bek, Ayşegül Oksal, Gülay Demi̇rci̇n, Mehmet Bülbül, Özlem Aydoğ, Ali̇ Deli̇baş, Ayşe Öner
Turkish Journal of Medical Sciences
To investigate the renal expression of apoptosis regulatory proteins b-cell lymphoma 2 (bcl-2) and bcl-2 associated X (bax) in children with Henoch–Schönlein nephritis (HSN) Materials and methods: Renal expression of antiapoptotic bcl-2 and proapoptotic bax proteins were studied immunohistochemically in 22 children with HSN. The kidneys of 5 children who died due to nonrenal reasons were used as the control. The patients were compared according to their renal histopathology and prognosis. Results: Nephrotic or nephrotic-nephritic renal involvement was the most common presentation. Histopathological findings were Class I in 1, Class II in 5, Class III in 10, Class IV in …
The Safety And Efficacy Of Remifentanil Compared To Fentanyl In Pediatric Endoscopy, Rauf Gül, Şami̇l Hizli, Betül Kocamer, Senem Koruk, Levent Şahi̇n, Hüseyi̇n Kilinçaslan, Vahap Sariçi̇çek
The Safety And Efficacy Of Remifentanil Compared To Fentanyl In Pediatric Endoscopy, Rauf Gül, Şami̇l Hizli, Betül Kocamer, Senem Koruk, Levent Şahi̇n, Hüseyi̇n Kilinçaslan, Vahap Sariçi̇çek
Turkish Journal of Medical Sciences
To compare propofol combinations with low induction doses of remifentanil and fentanyl in respect to the complication frequency and efficiency in ease of procedure in children undergoing esophagogastroduodenoscopy. Materials and methods: Sixty-four patients, aged 3-14 years and undergoing elective esophagogastroduodenoscopy, were included in the study. The patients received an induction dose of 0.25 µg kg^{-1} remifentanil and 2 mg kg^{-1} propofol (group R), or 0.5 µg kg^{-1} fentanyl and 2 mg kg^{-1} propofol (group F) before the procedure. The procedure began with a sedation score of >=5. Hemodynamic values, movement, ease and duration of the procedure, the time to awakening, …
Insulin Effect On Rankl And Opg Expression In Human Osteoblast-Like Mg63 Cells, Huixin Wang, Xiaohuan Zhong
Insulin Effect On Rankl And Opg Expression In Human Osteoblast-Like Mg63 Cells, Huixin Wang, Xiaohuan Zhong
Turkish Journal of Medical Sciences
To investigate the effect of insulin on receptor activator of nuclear factor kappa-B ligand (RANKL) and osteoprotegerin (OPG) expression in human osteosarcoma MG63 cells using real-time polymerase chain reaction. Materials and methods: MG63 cells were exposed to different concentrations of human recombinant insulin (1, 10, and 100 nM) for 24 h, and then the expression of RANKL and OPG mRNA was identified.After that, MG63 cells were exposed to tensile stress combined with 0 or 10 nM insulin respectively for 0, 3, 6, and 12 h, and then the expression of RANKL and OPG mRNA was identified. Human monocytes were cultured …
Double-J Stent Placement With Grasping Forceps Through Ureteroscope Working Channel: A Novel Technique, Aki̇f Koç, Ömer Bayrak
Double-J Stent Placement With Grasping Forceps Through Ureteroscope Working Channel: A Novel Technique, Aki̇f Koç, Ömer Bayrak
Turkish Journal of Medical Sciences
To report a new technique for the retrograde placement of a double-J stent with grasping forceps through the ureteroscope working channel. Materials and methods: In our technique, the ureteroscope is advanced to the renal pelvis or proximal location of the obstruction in the ureteral lumen; a double-J stent is then introduced into the ureteroscope working channel. The double-J stent is pushed forward until its proximal tip is seen; then the clamp over the distal tip of the pusher is opened and the guide-wire and pusher are removed from the channel, respectively. The grasping forceps is inserted into the working channel …
The Effect Of Hypercholesterolemia On The Contractions Of Detrusor Strips In Response To Neural Stimulation In Rats, Serkan Karai̇smai̇loğlu, Zeynep Di̇cle Balkanci, Bi̇lge Pehli̇vanoğlu, Si̇bel Bayrak, İsmai̇l Karabulut, Ayşen Erdem
The Effect Of Hypercholesterolemia On The Contractions Of Detrusor Strips In Response To Neural Stimulation In Rats, Serkan Karai̇smai̇loğlu, Zeynep Di̇cle Balkanci, Bi̇lge Pehli̇vanoğlu, Si̇bel Bayrak, İsmai̇l Karabulut, Ayşen Erdem
Turkish Journal of Medical Sciences
To investigate the effect of hypercholesterolemia on in vitro contractions of the detrusor smooth muscle stimulated by an electrical field in rats and the relative contributions of cholinergic and noncholinergic neurotransmission. Materials and methods: Sprague-Dawley rats were fed with standard diet (NC group) or with 4% cholesterol diet (HC group). After 4 weeks, the urinary bladder was excised under anesthesia and 4 detrusor strips were prepared. Blood samples were collected for serum lipid profile, and aortic arches were dissected for histopathological examination. In vitro contractile function of the detrusor smooth muscle was evaluated with: 1) electrical field stimulation (EFS) only, …