Open Access. Powered by Scholars. Published by Universities.®
- Discipline
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Verification Of Out-Of-Control Situations Detected By "Average Of Normal" Approach., Jiakai Liu, Chin Hon Tan, Tze Ping Loh, Tony Badrick
Verification Of Out-Of-Control Situations Detected By "Average Of Normal" Approach., Jiakai Liu, Chin Hon Tan, Tze Ping Loh, Tony Badrick
Tony Badrick
OBJECTIVES: "Average of normal" (AoN) or "moving average" is increasingly used as an adjunct quality control tool in laboratory practice. Little guidance exists on how to verify if an out-of-control situation in the AoN chart is due to a shift in analytical performance, or underlying patient characteristics. DESIGN AND METHODS: Through simulation based on clinical data, we examined 1) the location of the last apparently stable period in the AoN control chart after an analytical shift, and 2) an approach to verify if the observed shift is related to an analytical shift by repeat testing of archived patient samples from …
The Relationship Between Measurement Uncertainty And Reporting Interval, Tony Badrick, Robert C. Hawkins
The Relationship Between Measurement Uncertainty And Reporting Interval, Tony Badrick, Robert C. Hawkins
Tony Badrick
Background: Measurement uncertainty (MU) estimates can be used by clinicians in result interpretation for diagnosis and monitoring and by laboratories in assessing assay fitness for use and analytical troubleshooting. However, MU is not routinely used to assess the appropriateness of the analyte reporting interval.We describe the relationship between MU and the analyte reporting interval. Methods and results: The reporting interval R is the smallest unit of measurement chosen for clinical reporting. When choosing the appropriate value for R, it is necessary that the reference change values and expanded MU values can be meaningfully calculated. Expanded MU provides the tighter criterion …