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Detection Of Pharmaceuticals, Personal Care Products (Ppcps) And Illicit Drugs In Wastewater Treatment Plants And Urban River Systems, Mary L. Seaman

Theses and Dissertations

ABSTRACT

DETECTION OF PHARMACEUTICALS AND PERSONAL CARE PRODUCTS (PPCPS) AND ILLICIT DRUGS IN WASTEWATER TREATMENT PLANTS AND URBAN RIVER SYSTEMS

by Mary L Seaman The University of Wisconsin-Milwaukee, 2023 Under the Supervision of Professor Todd Miller, PhD

Pharmaceuticals, personal care products (PPCPs) and illicit drugs are a threat to human health and the aquatic environment globally. Their usage and consumption is rapidly increasing potentially due to an aging population, the development of new drugs, the overprescribing of prescription drugs and easier accessibility of drugs legally and illegally prescribed. These compounds enter wastewater treatment plants influent through urine or feces, pass …

Interactions Between Hiv And Opioids On Antiretroviral Accumulation, The Blood Brain Barrier, And The Inflammatory Response In The Brain., Kara Rademeyer

Theses and Dissertations

The complex mechanisms related to HIV infection, neurodegeneration, and chronic neuroinflammation collectively describe neuroHIV (Hauser et al. 2007; Chang et al. 2014; Smith et al. 2014). Specifically, opioid abuse, poor penetration of antiretroviral (ARV) drugs, chronic inflammation and neuronal injury/degeneration are all implicated in neuroHIV (Fantuzzi et al. 2003; Letendre et al. 2004; Verani et al. 2005; Duncan and Sattentau 2011; Hong and Banks 2015; Simoes and Justino 2015; Olivier et al. 2018; Murphy et al. 2019; Osborne et al. 2020). For the first time, we demonstrate that morphine, fentanyl, and methadone in vivo alter the brain accumulation of ARVs, …