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Statistical Investigation Of The Immune Response In Non-Human Primate Models, Annika Laser
Statistical Investigation Of The Immune Response In Non-Human Primate Models, Annika Laser
Theses and Dissertations
The human immunodeficiency virus (HIV) was first detected more than 30 years ago. Since then, intensive research has been done to develop a broadly protective vaccine, though without success. Our goal is to unveil some features of the protective immunity in non-human primate lentiviral infections in order to emulate HIV-infection. Two primate species have been studied, rhesus macaques (Rh) (Macaca mulatta) and African
green monkeys (Ag) (Chlorocebus spp.). Simian immunodeficiency virus (SIV) infection is non-pathogenic to Ag while Rh develop an AIDS-like illness. In this study, peripheral blood mononuclear cells (PBMC) from 8 Ag and 27 Rh were stimulated with …