Medicine and Health Sciences Commons^™

Memory Retrieval Is Maintained By Intrinsic And Synaptic Plasticity In Prelimbic Cortex, James Otis

Theses and Dissertations

Abnormally strong memories underlie common disorders including addiction and post-traumatic stress disorder (PTSD). Memory disruption would therefore be beneficial for treatment of these disorders. Evidence reveals that cocaine conditioned place preference (CPP) memories are susceptible to long-lasting disruption during memory retrieval. For example, inhibition of β-adrenergic receptor (β-AR) activity within the prelimbic medial prefrontal cortex (PL-mPFC) prevents cocaine CPP memory retrieval, and this retrieval impairment is both long-lasting and prevents subsequent reinstatement of the CPP. Despite this, whether PL-mPFC β-AR activity is a fundamental mechanism required to maintain retrieval of other memories is unclear. Furthermore, how PL-mPFC β-AR activity maintains …

Women's Experiences Living With Depression, Susan Marie Jarchow

Theses and Dissertations

In the United States, depression affects many Americans at different levels. Depression among women is a major public health problem. According to the National Alliance on Mental Illness), about 1 in 5 women develop depression at some point in their lives, and are nearly twice as likely as men to have depression. Much of the research about depression in women are quantitative studies aimed mostly at collecting epidemiological or survey data that focus on rates of mental illness, while not taking into account the qualitative subjective and contextual illness perspectives of women living with depression.

The purpose of this study …