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Full-Text Articles in Medicine and Health Sciences
Neurological Soft Signs Are Associated With Apoe Genotype, Age And Cognitive Performance, Nicola Lautenschlager, Jing-Shan Wu, Simon Laws, Osvaldo Almeida, Roger Clarnette, Karen Joesbury, Stefan Wagenpfeil, Georgia Martins, Athena Paton, Sam Gandy, Hans Forstl, Ralph Martins
Neurological Soft Signs Are Associated With Apoe Genotype, Age And Cognitive Performance, Nicola Lautenschlager, Jing-Shan Wu, Simon Laws, Osvaldo Almeida, Roger Clarnette, Karen Joesbury, Stefan Wagenpfeil, Georgia Martins, Athena Paton, Sam Gandy, Hans Forstl, Ralph Martins
Simon Laws
Neurodegeneration is associated with increased frequency of neurological soft signs (NSS). We designed the present study to investigate the association between NSS and subjective memory complaints, cognitive function and apolipoprotein E genotype in a community-dwelling sample of volunteers participating in an ongoing longitudinal program investigating predictors of cognitive decline. NSS were found to be associated with apolipoprotein E (APOE) ε4 genotype (p = 0.015), age (p = 0.012) and poor cognitive performance, as assessed by the Mini Mental State Examination (p = 0.053). There was no significant difference between subjects with and without memory complaints in relation to the frequency …
Association Of Cardiovascular Factors And Alzhemer's Disease Plasma Amyloid-Beta Protein In Subjective Memory Complainers, Kristyn Bates, Hamid Sohrabi, Mark Rodrigues, John Beilby, Satvinda Dhaliwal, Kevin Taddei, Arthur Criddle, Megan Wraith, Matthew Howard, Georgia Martins, Athena Paton, Pankaj Mehta, Jonathan Foster, Ian Martins, Nicola Launtenschlager, Frank Mastaglia, Simon Laws, Sam Gandy, Ralph Martins
Association Of Cardiovascular Factors And Alzhemer's Disease Plasma Amyloid-Beta Protein In Subjective Memory Complainers, Kristyn Bates, Hamid Sohrabi, Mark Rodrigues, John Beilby, Satvinda Dhaliwal, Kevin Taddei, Arthur Criddle, Megan Wraith, Matthew Howard, Georgia Martins, Athena Paton, Pankaj Mehta, Jonathan Foster, Ian Martins, Nicola Launtenschlager, Frank Mastaglia, Simon Laws, Sam Gandy, Ralph Martins
Simon Laws
A strong link is indicated between cardiovascular disease (CVD) and risk for developing Alzheimer's disease (AD), which may be exacerbated by the major AD genetic risk factor apolipoprotein Eε4 (APOEε4). Since subjective memory complaint (SMC) may potentially be an early indicator for cognitive decline, we examined CVD risk factors in a cohort of SMC. As amyloid-ε (Aβ) is considered to play a central role in AD, we hypothesized that the CVD risk profile (increased LDL, reduced HDL, and increased body fat) would be associated with plasma Aβ levels. We explored this in 198 individuals with and without SMC (average age …
No Association Of Lipase C Polymorphisms With Alzheimer's Disease, Simon Laws, Klaus Eckart, Patricia Friedrich, T Eisele, Alexander Kurz, H Forstl, Matthias Riemenschneider
No Association Of Lipase C Polymorphisms With Alzheimer's Disease, Simon Laws, Klaus Eckart, Patricia Friedrich, T Eisele, Alexander Kurz, H Forstl, Matthias Riemenschneider
Simon Laws
Hepatic lipase, also known as hepatic triglyceride lipase (LIPC), much like the major genetic risk factor for Alzheimer’s disease (AD), apolipoprotein E (APOE), is associated with altered lipid metabolism. As such this link makes LIPC a potential functional candidate for AD risk. Previously, three single nucleotide polymorphisms (SNPs) have been investigated in AD with a lack of association reported. To rule out a possible contribution of other variants in LIPC, located at 15q21-q23, we used a detailed fine mapping approach in a German case–control sample. Genotyping of 25 single nucleotide polymorphisms covering the complete LIPC gene and haplotypic analysis revealed …