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Full-Text Articles in Medicine and Health Sciences
Examination Of The Current Top Candidate Genes For Ad In A Genome-Wide Association Study, T Feulner, Simon Laws, Patricia Friedrich, S Wagenpfeil, S Wurst, K Kuhn, M Krawczak, S Schreiber, S Nikolaus, Hans Foerstl, Alexander Kurz, Matthias Riemenschneider
Examination Of The Current Top Candidate Genes For Ad In A Genome-Wide Association Study, T Feulner, Simon Laws, Patricia Friedrich, S Wagenpfeil, S Wurst, K Kuhn, M Krawczak, S Schreiber, S Nikolaus, Hans Foerstl, Alexander Kurz, Matthias Riemenschneider
Simon Laws
With the advent of technologies that allow simultaneous genotyping of thousands of singlenucleotide polymorphisms (SNPs) across the genome, the genetic contributions to complex diseases can be explored at an unprecedented detail. This study is among the first to apply the genome-wide association study (GWAS) approach to Alzheimer disease (AD). We present our GWAS results from the German population for genes included in the ‘Top Results’ list on the AlzGene database website. In addition to the apolipoprotein E locus, we identified nominally significant association signals in six of the ten genes investigated, albeit predominantly for SNPs other than those already published …
Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Simon Laws
Alzheimer disease (AD), vascular dementia, and stroke are all associated with inflammation though their respective initiating factors differ. Recently a polymorphism in the proinflammatory cytokine tumor necrosis factor (TNF), in association with apolipoprotein E (APOE), was reported to increase AD risk. Two SNPs, rs1799724 (–850C>T; NT_007592.14:g.22400733C>T) and rs1800629 (–308G>A; [NT_007592.14:g.22401282G>A]), and the APOE polymorphism were genotyped in 506 patients with sporadic AD and in 277 cognitively healthy controls. In a subset of 90 individuals we also investigated whether these SNPs exerted any functional effects on cerebrospinal fluid (CSF) beta-amyloid (Aβ) levels. The frequency of the rs1799724 …