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Gonadotropins And Cognition In Older Women, Mark Rodrigues, Giuseppe Verdile, Jonathan Foster, Eva Hogervorst, Karen Joesbury, Satvinder Dhaliwal, Elizabeth Corder, Simon Laws, Eugene Hone, Richard Prince, Amanda Devine, Pankaj Mehta, John Beilby, Craig Atwood, Ralph Martins
Gonadotropins And Cognition In Older Women, Mark Rodrigues, Giuseppe Verdile, Jonathan Foster, Eva Hogervorst, Karen Joesbury, Satvinder Dhaliwal, Elizabeth Corder, Simon Laws, Eugene Hone, Richard Prince, Amanda Devine, Pankaj Mehta, John Beilby, Craig Atwood, Ralph Martins
Simon Laws
Recent research studies associate elevated gonadotropin levels with dementia. Specifically, an age associated increase in levels of luteinizing hormone has been linked to an increased risk of Alzheimer's disease. The objective of this study was to investigate the association between gonadotropin levels and cognition in older, healthy postmenopausal women. Cognitive functioning was compared with plasma levels of estradiol, luteinizing hormone, follicle stimulating hormone, Aβ40 and APOE genetic status in 649 community-dwelling, non-demented older women residing in Western Australia. High endogenous luteinizing hormone levels were associated with a lower cognitive score, especially in older women and in those women that were …