Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
The Relationship Between Memory Complaints, Perceived Quality Of Life And Mental Health In Apolipoprotein Eepsilon4 Carriers And Non-Carriers, Hamid Sohrabi, Kristyn Bates, Mark Rodrigues, Kevin Taddei, Georgia Martins, Simon Laws, Nicola Lautenschlager, Satvinder Dhaliwal, Jonathan Foster, Ralph Martins
The Relationship Between Memory Complaints, Perceived Quality Of Life And Mental Health In Apolipoprotein Eepsilon4 Carriers And Non-Carriers, Hamid Sohrabi, Kristyn Bates, Mark Rodrigues, Kevin Taddei, Georgia Martins, Simon Laws, Nicola Lautenschlager, Satvinder Dhaliwal, Jonathan Foster, Ralph Martins
Simon Laws
Apolipoprotein E ε4 (APOE-ε4) is a major genetic risk factor for Alzheimer's disease. In this study, we addressed the question of whether possession of the APOE-ε4 allele results in adverse effects on perceived health-related quality of life (HRQL) and on symptoms of depression and anxiety in people with subjective memory complaints (SMC). 138 healthy, community-dwelling elderly volunteers, aged 52 to 85, were assessed for HRQL, depression, and anxiety. The participants were classified as i) APOE-ε4 carriers or ii) non-carriers with a) SMC or b) without memory complaints. The possible interactions of APOE genotype, gender, and SMC on HRQL, depression, and …