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Full-Text Articles in Medicine and Health Sciences
Plasma Amyloid-Β As A Biomarker In Alzheimer's Disease: The Aibl Study Of Aging , James Lui, Simon Laws, Qiao-Xin Li, Victor Villemagne, David Ames, Belinda Brown, Ashley Bush, Karl De Ruyck, Jasmin Dromey, Kathryn Ellis, Noel Faux, Jonathan Foster, Christopher Fowler, Veer Gupta, Peter Hudson, Katrina Laughton, Colin Masters, Kelly Pertile, Alan Rembach, Miroslava Rimajova, Mark Rodrigues, Christopher Rowe, Rebecca Rumble, Cassandra Szoecke, Kevin Taddei, Tania Taddei, Brett Trounson, Vanessa Ward
Plasma Amyloid-Β As A Biomarker In Alzheimer's Disease: The Aibl Study Of Aging , James Lui, Simon Laws, Qiao-Xin Li, Victor Villemagne, David Ames, Belinda Brown, Ashley Bush, Karl De Ruyck, Jasmin Dromey, Kathryn Ellis, Noel Faux, Jonathan Foster, Christopher Fowler, Veer Gupta, Peter Hudson, Katrina Laughton, Colin Masters, Kelly Pertile, Alan Rembach, Miroslava Rimajova, Mark Rodrigues, Christopher Rowe, Rebecca Rumble, Cassandra Szoecke, Kevin Taddei, Tania Taddei, Brett Trounson, Vanessa Ward
Simon Laws
Amyloid-β (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD) and has been postulated as a potential biomarker for AD. However, there is a lack of consensus as to its suitability as an AD biomarker. The objective of this study was to determine the significance of plasma Aβ as an AD biomarker and its relationship with Aβ load and to determine the effect of different assay methods on the interpretation of Aβ levels. Plasma Aβ1-40, Aβ1-42, and N-terminal cleaved fragments were measured using both a commercial multiplex assay and a well-documented ELISA in 1032 individuals drawn from …
Association Of Cardiovascular Factors And Alzhemer's Disease Plasma Amyloid-Beta Protein In Subjective Memory Complainers, Kristyn Bates, Hamid Sohrabi, Mark Rodrigues, John Beilby, Satvinda Dhaliwal, Kevin Taddei, Arthur Criddle, Megan Wraith, Matthew Howard, Georgia Martins, Athena Paton, Pankaj Mehta, Jonathan Foster, Ian Martins, Nicola Launtenschlager, Frank Mastaglia, Simon Laws, Sam Gandy, Ralph Martins
Association Of Cardiovascular Factors And Alzhemer's Disease Plasma Amyloid-Beta Protein In Subjective Memory Complainers, Kristyn Bates, Hamid Sohrabi, Mark Rodrigues, John Beilby, Satvinda Dhaliwal, Kevin Taddei, Arthur Criddle, Megan Wraith, Matthew Howard, Georgia Martins, Athena Paton, Pankaj Mehta, Jonathan Foster, Ian Martins, Nicola Launtenschlager, Frank Mastaglia, Simon Laws, Sam Gandy, Ralph Martins
Simon Laws
A strong link is indicated between cardiovascular disease (CVD) and risk for developing Alzheimer's disease (AD), which may be exacerbated by the major AD genetic risk factor apolipoprotein Eε4 (APOEε4). Since subjective memory complaint (SMC) may potentially be an early indicator for cognitive decline, we examined CVD risk factors in a cohort of SMC. As amyloid-ε (Aβ) is considered to play a central role in AD, we hypothesized that the CVD risk profile (increased LDL, reduced HDL, and increased body fat) would be associated with plasma Aβ levels. We explored this in 198 individuals with and without SMC (average age …