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The Role Of Beta Amyloid In Alzheimer's Disease: Still A Cause Of Everything Or The Only One Who Got Caught?, Giuseppe Verdile, Stephanie Fuller, Craig Atwood, Simon Laws, Samuel Gandy, Ralph Martins

Simon Laws

The beta amyloid (Aβ) protein is a key molecule in the pathogenesis of Alzheimer’s disease (AD). The tendency of the Aβ peptide to aggregate, its reported neurotoxicity, and genetic linkage studies, have led to a hypothesis of AD pathogenesis that many AD researchers term the amyloid cascade hypothesis. In this hypothesis, an increased production of Aβ results in neurodegeneration and ultimately dementia through a cascade of events. In the past 15 years, debate amongst AD researchers has arisen as to whether Aβ is a cause or an effect of the pathogenic process. Recent in vitro and in vivo research has …