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Cognition And Beta-Amyloid In Preclinical Alzheimer's Disease: Data From The Aibl Study, Kerryn Pike, Kathryn A Ellis, Victor L Villemagne, Norm Good, Gael Chetelat, David Ames, Cassandra Szoeke, Simon Laws, Giuseppe Verdile, Ralph Martins, Colin L Masters, Christopher C Rowe

Simon Laws

The ‘preclinical’ phase of Alzheimer's disease is a future target for treatment, but additional research is essential to understand the relationship between β-amyloid burden and cognition during this time. We investigated this relationship using a large sample of apparently healthy older adults (N = 177), which also enabled examination of whether the relationship differed according to age, gender, years of education, apolipoprotein E status, and the presence of subjective memory complaints. In addition to episodic memory, a range of cognitive measures (global cognition, semantic memory, visuospatial performance, and executive function) were examined. Participants were aged over 60 years with no …