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Full-Text Articles in Medicine and Health Sciences
Homocysteine, Vitamin B12, And Folic Acid Levels In Alzheimer's Disease, Mild Cognitive Impairment, And Healthy Elderly: Baseline Characteristics In Subjects Of The Australian Imaging Biomarker Lifestyle Study., Noel Faux, Kathryn Ellis, Lorine Porter, Chris Fowler, Simon Laws, Ralph Martins, Kelly Pertile, Alan Rembach, Chris Rowe, Rebecca Rumble, Cassandra Szoeke, Kevin Taddei, Tania Taddei, Brett Trounson, Victor Villemagne, Vanessa Ward, David Ames, Colin Masters, Ashley Bush
Homocysteine, Vitamin B12, And Folic Acid Levels In Alzheimer's Disease, Mild Cognitive Impairment, And Healthy Elderly: Baseline Characteristics In Subjects Of The Australian Imaging Biomarker Lifestyle Study., Noel Faux, Kathryn Ellis, Lorine Porter, Chris Fowler, Simon Laws, Ralph Martins, Kelly Pertile, Alan Rembach, Chris Rowe, Rebecca Rumble, Cassandra Szoeke, Kevin Taddei, Tania Taddei, Brett Trounson, Victor Villemagne, Vanessa Ward, David Ames, Colin Masters, Ashley Bush
Simon Laws
There is some debate regarding the differing levels of plasma homocysteine, vitamin B12 and serum folate between healthy controls (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). As part of the Australian Imaging Biomarker Lifestyle (AIBL) study of aging cohort, consisting of 1,112 participants (768 HC, 133 MCI patients, and 211 AD patients), plasma homocysteine, vitamin B12, and serum and red cell folate were measured at baseline to investigate their levels, their inter-associations, and their relationships with cognition. The results of this cross-sectional study showed that homocysteine levels were increased in female AD patients compared to female HC subjects …
Olfactory Dysfunction Is Associated With Subjective Memory Complaints In Community-Dwelling Elderly Individuals, Hamid Sohrabi, Kristyn Bates, Mark Rodrigues, Kevin Taddei, Simon Laws, Nicola Lautenschlager, Satvinder Dhaliwal, Amy Johnston, Alan Mackay-Sim, Samuel Gandy, Jonathan Foster, Ralph Martins
Olfactory Dysfunction Is Associated With Subjective Memory Complaints In Community-Dwelling Elderly Individuals, Hamid Sohrabi, Kristyn Bates, Mark Rodrigues, Kevin Taddei, Simon Laws, Nicola Lautenschlager, Satvinder Dhaliwal, Amy Johnston, Alan Mackay-Sim, Samuel Gandy, Jonathan Foster, Ralph Martins
Simon Laws
Olfactory dysfunction has been reported in clinical and preclinical phases of Alzheimer's disease. Subjective memory complaints have been proposed as a potential early indicator for increased risk of Alzheimer's disease, but have also been associated with depression, personality characteristics, and health problems. In this study, we aimed to determine which of these putative markers can predict memory complaints in community-dwelling elderly individuals, focusing on olfactory symptoms. A cohort of 144 elderly volunteers (42 males and 102 females), aged 50 to 86, was recruited from an ongoing longitudinal study. Participants were assessed for olfactory capacities (threshold, discrimination, and identification), subjective memory …
Plasma Amyloid-Β As A Biomarker In Alzheimer's Disease: The Aibl Study Of Aging , James Lui, Simon Laws, Qiao-Xin Li, Victor Villemagne, David Ames, Belinda Brown, Ashley Bush, Karl De Ruyck, Jasmin Dromey, Kathryn Ellis, Noel Faux, Jonathan Foster, Christopher Fowler, Veer Gupta, Peter Hudson, Katrina Laughton, Colin Masters, Kelly Pertile, Alan Rembach, Miroslava Rimajova, Mark Rodrigues, Christopher Rowe, Rebecca Rumble, Cassandra Szoecke, Kevin Taddei, Tania Taddei, Brett Trounson, Vanessa Ward
Plasma Amyloid-Β As A Biomarker In Alzheimer's Disease: The Aibl Study Of Aging , James Lui, Simon Laws, Qiao-Xin Li, Victor Villemagne, David Ames, Belinda Brown, Ashley Bush, Karl De Ruyck, Jasmin Dromey, Kathryn Ellis, Noel Faux, Jonathan Foster, Christopher Fowler, Veer Gupta, Peter Hudson, Katrina Laughton, Colin Masters, Kelly Pertile, Alan Rembach, Miroslava Rimajova, Mark Rodrigues, Christopher Rowe, Rebecca Rumble, Cassandra Szoecke, Kevin Taddei, Tania Taddei, Brett Trounson, Vanessa Ward
Simon Laws
Amyloid-β (Aβ) plays a central role in the pathogenesis of Alzheimer's disease (AD) and has been postulated as a potential biomarker for AD. However, there is a lack of consensus as to its suitability as an AD biomarker. The objective of this study was to determine the significance of plasma Aβ as an AD biomarker and its relationship with Aβ load and to determine the effect of different assay methods on the interpretation of Aβ levels. Plasma Aβ1-40, Aβ1-42, and N-terminal cleaved fragments were measured using both a commercial multiplex assay and a well-documented ELISA in 1032 individuals drawn from …
The Relationship Between Memory Complaints, Perceived Quality Of Life And Mental Health In Apolipoprotein Eepsilon4 Carriers And Non-Carriers, Hamid Sohrabi, Kristyn Bates, Mark Rodrigues, Kevin Taddei, Georgia Martins, Simon Laws, Nicola Lautenschlager, Satvinder Dhaliwal, Jonathan Foster, Ralph Martins
The Relationship Between Memory Complaints, Perceived Quality Of Life And Mental Health In Apolipoprotein Eepsilon4 Carriers And Non-Carriers, Hamid Sohrabi, Kristyn Bates, Mark Rodrigues, Kevin Taddei, Georgia Martins, Simon Laws, Nicola Lautenschlager, Satvinder Dhaliwal, Jonathan Foster, Ralph Martins
Simon Laws
Apolipoprotein E ε4 (APOE-ε4) is a major genetic risk factor for Alzheimer's disease. In this study, we addressed the question of whether possession of the APOE-ε4 allele results in adverse effects on perceived health-related quality of life (HRQL) and on symptoms of depression and anxiety in people with subjective memory complaints (SMC). 138 healthy, community-dwelling elderly volunteers, aged 52 to 85, were assessed for HRQL, depression, and anxiety. The participants were classified as i) APOE-ε4 carriers or ii) non-carriers with a) SMC or b) without memory complaints. The possible interactions of APOE genotype, gender, and SMC on HRQL, depression, and …