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A Functional Polymorphism Within Plasminogen Activator Urokinase (Plau) Is Associated With Alzheimer's Disease, Matthias Riemenschneider, Lidija Konta, Patricia Friedrich, Sandra Schwarz, Kevin Taddei, Frauke Neff, Alessandro Padovani, Heike Kolsch, Simon Laws, Norman Klopp, Heike Bickeboller, Stefan Wagenpfeil, Jakob Mueller, Albert Rosenberger, Janine Diehl-Schmid, Silvana Archetti, Nicola Lautenschlager, Barbara Borroni, Ulrich Muller, Thomas Illig, Reinhard Heun, Rupert Egensperger, Jurgen Schlege, Hans Forstl, Ralph Martins, German Sib-Pair Study Group, Alexander Kurz
A Functional Polymorphism Within Plasminogen Activator Urokinase (Plau) Is Associated With Alzheimer's Disease, Matthias Riemenschneider, Lidija Konta, Patricia Friedrich, Sandra Schwarz, Kevin Taddei, Frauke Neff, Alessandro Padovani, Heike Kolsch, Simon Laws, Norman Klopp, Heike Bickeboller, Stefan Wagenpfeil, Jakob Mueller, Albert Rosenberger, Janine Diehl-Schmid, Silvana Archetti, Nicola Lautenschlager, Barbara Borroni, Ulrich Muller, Thomas Illig, Reinhard Heun, Rupert Egensperger, Jurgen Schlege, Hans Forstl, Ralph Martins, German Sib-Pair Study Group, Alexander Kurz
Simon Laws
A number of susceptibility loci for Alzheimer's disease (AD) have been identified including a region on Chromosome 10q21–q22. Within this region the plasminogen activator urokinase gene (PLAU) was considered as a reasonable candidate from its functional implication in plasmin generation, a serine protease capable of degrading beta-Amyloid (Aβ) protein. We screened 56 single nucleotide polymorphisms (SNPs) around PLAU using 1751 individuals from four independent case–control samples (Munich, N=679; Bonn N=282; Brescia (Italy) N=219; Perth (Australia) N=557 and one discordant sib-pair sample (Munich N=622). In brain tissue samples of neuropathologically confirmed cases with AD (N=33) we analyzed plaque counts according to …