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Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Tnf Polymorphisms In Alzheimer Disease And Functional Implications On Csf Beta-Amyloid Levels, Simon Laws, Robert Perneczky, Stefan Wagenpfeil, Ulrich Muller, Hans Forstl, Ralph Martins, Alexander Kurz, Matthias Riemenschneider
Simon Laws
Alzheimer disease (AD), vascular dementia, and stroke are all associated with inflammation though their respective initiating factors differ. Recently a polymorphism in the proinflammatory cytokine tumor necrosis factor (TNF), in association with apolipoprotein E (APOE), was reported to increase AD risk. Two SNPs, rs1799724 (–850C>T; NT_007592.14:g.22400733C>T) and rs1800629 (–308G>A; [NT_007592.14:g.22401282G>A]), and the APOE polymorphism were genotyped in 506 patients with sporadic AD and in 277 cognitively healthy controls. In a subset of 90 individuals we also investigated whether these SNPs exerted any functional effects on cerebrospinal fluid (CSF) beta-amyloid (Aβ) levels. The frequency of the rs1799724 …