Medicine and Health Sciences Commons^™

Von Willebrand Factor Levels In The Diagnosis Of Von Willebrand Disease: A Systematic Review And Meta-Analysis, Mohamad A. Kalot, Nedaa Husainat, Abdallah El Alayli, Omar Abughanimeh, Osama Diab, Sammy Tayiem, Bader Madoukh, Ahmad Bilal Dimassi, Aref Qureini, Barbara Ameer

School of Medicine Publications and Presentations

Von Willebrand Disease (VWD) is associated with significant morbidity as a result of excessive mucocutaneous bleeding symptoms. Patients with VWD can experience easy bruising, epistaxis, gastrointestinal and oral cavity bleeding, as well as heavy menstrual bleeding and bleeding after dental work, surgical procedures, and childbirth. Early diagnosis and treatment is important to prevent and treat these symptoms. We systematically reviewed the accuracy of diagnostic tests using different cut-off values of VWF:Ag and platelet-dependent VWF activity assays in the diagnosis of VWD. We searched Cochrane Central, MEDLINE, and EMBASE for eligible studies. Two investigators screened and abstracted data. Risk of bias …

Covid-19 And Chronic Diabetes: The Perfect Storm For Reactivation Tuberculosis?: A Case Series, Genesis P. Aguillón-Durán, Ericka Prieto-Martinez Dr, Doris Ayala, Juan García Jr., John M. Thomas Iii, Juan Ignacio García, Brandon Michael Henry, Jordi B. Torrelles, Joanne Turner, Eder Ledezma-Campos, Blanca I. Restrepo

School of Medicine Publications and Presentations

Background

The coronavirus disease 2019 pandemic is predicted to have a net negative effect on tuberculosis control, with an estimated excess of 6.3 million tuberculosis cases and 1.4 million deaths by 2025. Programmatic issues such as the lockdown of tuberculosis services affect all patients, while biosocial factors have a differential impact on an individual’s risk for tuberculosis or adverse tuberculosis outcomes.

Case presentation

We report three Hispanic cases of incident tuberculosis (two males, 43 and 44 years old; one female, 49 years old) after resolution of coronavirus disease episodes. Coincidentally, all cases shared a common risk factor: a chronic history …

Lrg1 Is An Adipokine That Mediates Obesity-Induced Hepatosteatosis And Insulin Resistance, Sijia He, Jiyoon Ryu, Juanhong Liu, Hairong Luo, Ying Lv, Paul R. Langlais, Jie Wen, Feng Dong, Zhe Sun, Ravindranath Duggirala

School of Medicine Publications and Presentations

Dysregulation in adipokine biosynthesis and function contributes to obesity-induced metabolic diseases. However, the identities and functions of many of the obesity-induced secretory molecules remain unknown. Here, we report the identification of leucine-rich alpha-2-glycoprotein 1 (LRG1) as an obesity-associated adipokine that exacerbates high fat diet–induced hepatosteatosis and insulin resistance. Serum levels of LRG1 were markedly elevated in obese humans and mice compared with their respective controls. LRG1 deficiency in mice greatly alleviated diet-induced hepatosteatosis, obesity, and insulin resistance. Mechanistically, LRG1 bound with high selectivity to the liver and promoted hepatosteatosis by increasing de novo lipogenesis and suppressing fatty acid β-oxidation. LRG1 …

Efficacy And Safety Of Covid-19 Convalescent Plasma In Hospitalized Patients: A Randomized Clinical Trial, Mila B. Ortigoza, Hyunah Yoon, Keith S. Goldfeld, Andrea B. Troxel, Johanna P. Daily, Yinxiang Wu, Yi Li, Danni Wu, Gia F. Cobb, Andrew N. Dentino

School of Medicine Publications and Presentations

Importance: There is clinical equipoise for COVID-19 convalescent plasma (CCP) use in patients hospitalized with COVID-19.

Objective: To determine the safety and efficacy of CCP compared with placebo in hospitalized patients with COVID-19 receiving noninvasive supplemental oxygen.

Design, setting, and participants: CONTAIN COVID-19, a randomized, double-blind, placebo-controlled trial of CCP in hospitalized adults with COVID-19, was conducted at 21 US hospitals from April 17, 2020, to March 15, 2021. The trial enrolled 941 participants who were hospitalized for 3 or less days or presented 7 or less days after symptom onset and required noninvasive oxygen supplementation.

Interventions: A unit of …

Case Report: Neurologic Presentation Of West Nile Virus: Difficult Diagnosis, Eron G. Manusov, Amalia Mora Campuzano, Omar Ahmed, Samantha Macias, Carolina Gomez De Ziegler, Gerardo Munoz Monaco

School of Medicine Publications and Presentations

West Nile virus infections have surged across the globe. South Texas, located on the path of bird migration, with Culex quinquefasciatus and other Culex species, and biotic primers that predispose the area to epidemics (floods, amplifying hosts, and lack of mosquito control and prevention) remains a highly endemic area for arbovirus spread. West Nile virus infection ranges from mild febrile illness to severe central nervous system involvement. The purpose of this report is to highlight complex presentations of WNV and how confounding presenting symptoms delay diagnosis. The secondary goal is to describe how pandemics, such as SARS-CoV-2, can overwhelm the …

Candida Pericarditis Presenting With Cardiac Tamponade And Multiple Organ Failure After Combined Damage Control Thoracotomy And Laparotomy With Splenectomy In A Trauma Patient: Case Report And Review Of Literature, R. A. Siller, Jeffrey Skubic, J. L. Almeda, Adolfo E. Kaplan

School of Medicine Publications and Presentations

Candida pericarditis is a rare condition which has previously been described after cardiothoracic surgery and immunosuppressive states (Geisler et al., 1981; Eng et al., 1981; Kraus et al., 1988; Kaufman et al., 1988; Tang et al., 2009; Glower et al., 1990; Carrel et al., 1991; Rabinovici et al., 1997; Canver et al., 1998; Farjah et al., 2005; Gronemeyer et al., 1982 [1-11]). We describe the case of a 19-year-old male blunt trauma patient, who survived a damage control thoracotomy and laparotomy with splenectomy, who later developed a loculated Candida pericardial effusion, complicated with cardiac tamponade and multiple organ failure, and …

Steviol Represses Glucose Metabolism And Translation Initiation In Pancreatic Cancer Cells, Sonam Kumari, Mohammed Sikander, Shabnam Malik, Manish Tripathi, Bilal B. Hafeez, Murali M. Yallapu, Subhash C. Chauhan, Sheema Khan, Meena Jaggi

School of Medicine Publications and Presentations

Pancreatic cancer has the worst prognosis and lowest survival rate among all cancers. Pancreatic cancer cells are highly metabolically active and typically reprogrammed for aberrant glucose metabolism; thus they respond poorly to therapeutic modalities. It is highly imperative to understand mechanisms that are responsible for high glucose metabolism and identify natural/synthetic agents that can repress glucose metabolic machinery in pancreatic cancer cells, to improve the therapeutic outcomes/management of pancreatic cancer patients. We have identified a glycoside, steviol that effectively represses glucose consumption in pancreatic cancer cells via the inhibition of the translation initiation machinery of the molecular components. Herein, we …

Reassessing Associations Between White Matter And Behaviour With Multimodal Microstructural Imaging, Alberto Lazari, Piergiorgio Salvan, Michiel Cottaar, Daniel Papp, Olof Jens Van Der Werf, Ainslie Johnstone, Zeena-Britt Sanders, Cassandra Sampaio-Baptista, Nicole Eichert, Anderson M. Winkler

School of Medicine Publications and Presentations

Several studies have established specific relationships between White Matter (WM) and behaviour. However, these studies have typically focussed on fractional anisotropy (FA), a neuroimaging metric that is sensitive to multiple tissue properties, making it difficult to identify what biological aspects of WM may drive such relationships. Here, we carry out a pre-registered assessment of WM-behaviour relationships in 50 healthy individuals across multiple behavioural and anatomical domains, and complementing FA with myelin-sensitive quantitative MR modalities (MT, R1, R2∗).

Surprisingly, we only find support for predicted relationships between FA and behaviour in one of three pre-registered tests. For one behavioural domain, …

Neuroimaging Association Scores: Reliability And Validity Of Aggregate Measures Of Brain Structural Features Linked To Mental Disorders In Youth, Luiza Kvitko Axelrud, André Rafael Simioni, Daniel Samuel Pine, Anderson M. Winkler, Pedro Mario Pan, João Ricardo Sato, André Zugman, Nadine Parker, Felipe Picon, Andrea Jackowski

School of Medicine Publications and Presentations

In genetics, aggregation of many loci with small effect sizes into a single score improved prediction. Nevertheless, studies applying easily replicable weighted scores to neuroimaging data are lacking. Our aim was to assess the reliability and validity of the Neuroimaging Association Score (NAS), which combines information from structural brain features previously linked to mental disorders. Participants were 726 youth (aged 6–14) from two cities in Brazil who underwent MRI and psychopathology assessment at baseline and 387 at 3-year follow-up. Results were replicated in two samples: IMAGEN (n = 1627) and the Healthy Brain Network (n = 843). NAS …

Investigating The Relations Between Caffeine-Derived Metabolites And Plasma Lipids In 2 Population-Based Studies, Dusan Petrovic, Menno Pruijm, Belén Ponte, Nasser A. Dhayat, Daniel Ackermann, Georg Ehret, Nicolas Ansermot, Bruno Vogt, Pierre-Yves Martin, Jesus D. Melgarejo

School of Medicine Publications and Presentations

Objective: To investigate the relations between caffeine-derived metabolites (methylxanthines) and plasma lipids by use of population-based data from 2 European countries.

Methods: Families were randomly selected from the general population of northern Belgium (FLEMENGHO), from August 12, 1985, until November 22, 1990, and 3 Swiss cities (SKIPOGH), from November 25, 2009, through April 4, 2013. We measured plasma concentrations (FLEMENGHO, SKIPOGH) and 24-hour urinary excretions (SKIPOGH) of 4 methylxanthines-caffeine, paraxanthine, theobromine, and theophylline-using ultra-high-performance liquid chromatography-tandem mass spectrometry. We used enzymatic methods to estimate total cholesterol, high-density lipoprotein cholesterol, and triglyceride levels and the Friedewald equation for low-density lipoprotein cholesterol …

How Should Medical Schools Foster Equity And Inclusion In Admissions?, Adela Valdez, Lala Forrest, Alessandra Jimenez, Kim-Thu Pham

School of Medicine Publications and Presentations

This commentary in response to a case considers how merit and features of medical school applicants’ dossiers should be drawn upon in admissions processes to promote equity and inclusion in medicine. It is argued that medical schools should incentivize inclusion by redefining merit in their admissions goals and processes, promote meaningful inclusion, and show institutional leadership in addressing social justice.

Searching For Imaging Biomarkers Of Psychotic Dysconnectivity, Amanda L. Rodrigue, Dana Mastrovito, Oscar Esteban, Joke Durnez, Marinka M. G. Koenis, Ronald Janssen, Aaron Alexander-Bloch, Emma M. Knowles, Samuel R. Mathias, John Blangero

School of Medicine Publications and Presentations

Background: Progress in precision psychiatry is predicated on identifying reliable individual-level diagnostic biomarkers. For psychosis, measures of structural and functional connectivity could be promising biomarkers given consistent reports of dysconnectivity across psychotic disorders using magnetic resonance imaging.

Methods: We leveraged data from four independent cohorts of patients with psychosis and control subjects with observations from approximately 800 individuals. We used group-level analyses and two supervised machine learning algorithms (support vector machines and ridge regression) to test within-, between-, and across-sample classification performance of white matter and resting-state connectivity metrics.

Results: Although we replicated group-level differences in brain connectivity, individual-level classification …

Bay Leaf Extract‐Based Near‐Infrared Fluorescent Probe For Tissue And Cellular Imaging, Benilde Adriano, Nycol Cotto, Neeraj Chauhan, Vinitha Karumuru, Meena Jaggi, Subhash C. Chauhan, Murali M. Yallapu

School of Medicine Publications and Presentations

The development of fluorescence dyes for near‐infrared (NIR) fluorescence imaging has been a significant interest for deep tissue imaging. Among many imaging fluoroprobes, indocyanine green (ICG) and its analogues have been used in oncology and other medical applications. However, these imaging agents still experience poor imaging capabilities due to low tumor targetability, photostability, and sensitivity in the biological milieu. Thus, developing a biocompatible NIR imaging dye from natural resources holds the potential of facilitating cancer cell/tissue imaging. Chlorophyll (Chl) has been demonstrated to be a potential candidate for imaging purposes due to its natural NIR absorption qualities and its wide …

College Students’ Well-Being During The Covid-19 Pandemic: A Systematic Review Of The Literature, Michaela Q. Iglesia, Ming-Tsan Lu

School of Medicine Publications and Presentations

Studies have shown increased levels of distress during the coronavirus disease-19 (COVID-19) pandemic, and college students are becoming more recognized as a vulnerable population. This narrative systematic review aims to synthesize the current understanding of mental health, lifestyle, and socioeconomic impacts that the pandemic had on college students in the United States. A search was conducted on PubMed, PsycInfo, and Web of Science. A total of 34 observational studies were included which examined aspects of college students’ health and experiences during the COVID-19 pandemic in the United States. A great deal of students was shown to experience a moderate level …

Airway Epithelial Innate Immunity, Sebastian L. Johnston, David L. Goldblatt, Scott E. Evans, Michael J. Tuvim, Burton F. Dickey

School of Medicine Publications and Presentations

Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of the innate immune system with specificity for different pathogen classes. It occurs in the context of numerous interactions with leukocytes, but here we focus on intrinsic epithelial mechanisms. Type 1 immune responses are directed primarily at intracellular pathogens, particularly viruses. Prominent stimuli include microbial nucleic acids and interferons released from neighboring epithelial cells. Epithelial responses revolve around changes in the expression of interferon-sensitive genes (ISGs) that interfere with viral replication, as well as the further induction of interferons that …

Dna Damage Is Overcome By Trip13 Overexpression During Cisplatin Nephrotoxicity, Taketsugu Hama, Prashanth K.B. Nagesh, Pallabita Chowdhury, Bob M. Moore Ii, Murali M. Yallapu, Kevin R. Regner, Frank Park

School of Medicine Publications and Presentations

Cisplatin is a commonly used chemotherapeutic agent to treat a wide array of cancers that is frequently associated with toxic injury to the kidney due to oxidative DNA damage and perturbations in cell cycle progression leading to cell death. In this study, we investigated whether thyroid receptor interacting protein 13 (TRIP13) plays a central role in the protection of the tubular epithelia following cisplatin treatment by circumventing DNA damage. Following cisplatin treatment, double-stranded DNA repair pathways were inhibited using selective blockers to proteins involved in either homologous recombination or non-homologous end joining. This led to increased blood markers of acute …

Case Report: Pafah1b1 Mutation And Posterior Band Heterotopia With Focal Temporal Lobe Epilepsy Treated By Responsive Neurostimulation, Frank G. Gilliam, Paddy Ssentongo, Michael Sather, Yuka I. Kawasawa

School of Medicine Publications and Presentations

Subcortical band heterotopia (SBH), also known as double cortex syndrome, is a malformation of cortical development caused by inherited or somatic gene variants. We present a case of a young adult with posterior SBH and electroclinical features of focal neocortical temporal lobe epilepsy. Genomic blood analysis identified a pathogenic somatic mosaicism duplication variant of the PAFAH1B1 gene. Despite bilateral cortical MRI abnormalities, the interictal and ictal EEG findings indicated a focal epileptogenic region in the left posterior temporal region. Chronic responsive cortical neurostimulation across two four-contact depth electrodes placed 5mm on either side of the maximal interictal spiking identified during …

Acquired Factor Viii Deficiency Presenting As Gross Hematuria In A Hispanic, Pregnant Patient With Previously Undiagnosed Connective Tissue Disease, Christine Loftis, Emilia C. Dulgheru, Rosa White

School of Medicine Publications and Presentations

Acquired factor VIII deficiency is a bleeding disorder caused by the presence of autoantibodies against clotting factor VIII. We report a case of a 24-year-old pregnant woman who presented with gross hematuria secondary to acquired factor VIII deficiency in the presence of a previously undiagnosed connective tissue disease. *is article includes a literature review of pregnancy-related cases of acquired factor VIII deficiency. We also reviewed various therapeutic approaches for the management of the acquired factor inhibitor which include achieving hemostasis and elimination of the inhibitor via immunosuppressive agents. *is case report describes the rare presentation of acquired factor VIII deficiency …

Dermatomyositis- Related Intestinal Dysmotility, Christine Loftis, Rosa White, Emilia C. Dulgheru

School of Medicine Publications and Presentations

Dermatomyositis (DM) is an inflammatory myopathy (IIM) characterized by proximal muscle weakness and pathognomonic skin lesions. A 69-year-old woman with a recent diagnosis of DM 1 month prior, treated with corticosteroids and immunomodulators, presented to our inpatient rehabilitation with worsening dysphagia and constipation. At the time of our evaluation, physical examination was notable for erythematous papules over the metacarpophalangeal joints, proximal interphalangeal joints, elbows, and knees as well as a violaceous rash on the face. Muscle strength was diminished bilaterally with proximal distribution being affected greater than distal. Laboratory studies were notable for the creatine kinase (CK) level of 31 …

Diabetes Mellitus Correlates With Increased Biological Age As Indicated By Clinical Biomarkers, Nadine Bahour, Briana Cortez, Hui Pan, Hetal Shah, Alessandro Doria, Cristina Aguayo‑Mazzucato

School of Medicine Publications and Presentations

Chronological age (CA) is determined by time of birth, whereas biological age (BA) is based on changes on a cellular level and strongly correlates with morbidity, mortality, and longevity. Type 2 diabetes (T2D) associates with increased morbidity and mortality; thus, we hypothesized that BA would be increased and calculated it from biomarkers collected at routine clinical visits. Deidentified data was obtained from three cohorts of patients (20-80 years old)-T2D, type 1 diabetes (T1D), and prediabetes-and compared to gender- and age-matched non-diabetics. Eight clinical biomarkers that correlated with CA in people without diabetes were used to calculate BA using the Klemera …

Looking For Crumbs In The Obesity Forest: Anti-Obesity Interventions And Obesity-Associated Cardiometabolic Traits In The Mexican Population. History And Systematic Review With Meta-Analyses, Esperanza M. Garcia-Oropesa, Yoscelina E. Martinez-Lopez, Sonia María Ruiz-Cejudo, José Darío Martínez-Ezquerro, Alvaro Diaz-Badillo, Carlos Ramirez-Pfeiffer, Alejandra Bustamante-Fuentes, Elena B. Lopez-Sosa, Oscar O. Moctezuma-Chavez, Edna J. Nava-Gonzalez, Adriana L. Perales-Torres, Lucia M. Perez-Navarro, Marisol Rosas-Diaz, Kathleen V. Carter, Beatriz Tapia, Juan C. Lopez-Alvarenga

School of Medicine Publications and Presentations

Mexicans and Mexican Americans share culture, genetic background, and predisposition for chronic complications associated with obesity and diabetes making imperative efficacious treatments and prevention. Obesity has been treated for centuries focused-on weight loss while other treatments on associated conditions like gout, diabetes (T2D), and hypertriglyceridemia. To date, there is no systematic review that synthesizes the origin of obesity clinics in Mexico and the efforts to investigate treatments for obesity tested by randomized clinical trials (RCT). We conducted systematic searches in Pubmed, Scopus, and Web of Science to retrieve anti-obesity RCT through 2019 and without an inferior temporal limit. The systematic …

A High-Resolution Hla Reference Panel Capturing Global Population Diversity Enables Multi-Ethnic Fine-Mapping In Hiv Host Response, Yang Luo, Masahiro Kanai, Wanson Choi, Xinyi Li, John Blangero, Joanne E. Curran, Ravi Duggirala, Harald H. H. Goring, Michael C. Mahaney, Juan M. Peralta

School of Medicine Publications and Presentations

No abstract provided.

Comparing Empirical Kinship Derived Heritability For Imaging Genetics Traits In The Uk Biobank And Human Connectome Project, Si Gao, Brian Donohue, Kathryn S. Hatch, Shuo Chen, Tianzhou Ma, Yizhou Ma, Mark D. Kvarta, Bhim M. Adhikari, Neda Jahanshad, John Blangero

School of Medicine Publications and Presentations

Imaging genetics analyses use neuroimaging traits as intermediate phenotypes to infer the degree of genetic contribution to brain structure and function in health and/or illness. Coefficients of relatedness (CR) summarize the degree of genetic similarity among subjects and are used to estimate the heritability – the proportion of phenotypic variance explained by genetic factors. The CR can be inferred directly from genome-wide genotype data to explain the degree of shared variation in common genetic polymorphisms (SNP-heritability) among related or unrelated subjects. We developed a central processing and graphics processing unit (CPU and GPU) accelerated Fast and Powerful Heritability Inference …

Should Employment Division V Smith Be Overturned?, Jake Greenblum, Ryan Hubbard

School of Medicine Publications and Presentations

Health professionals seeking religious exemption from caring for some patients or providing some interventions receive robust legal protection. Similarly, religiously affiliated organizations have great latitude in deciding which services to offer. These protections could soon become stronger, as the US Supreme Court considers 2 cases that revisit constraints on exemption claims established in Employment Division, Department of Human Resources of Oregon v Smith (1990). This article contends that overturning this case’s precedent might result in clinicians claiming more religious exemptions, which, barring acts of US Congress, would erode the rule of law and increase risk of harm to patients.

Recent Advances In Understanding Neural Correlates Of Anxiety Disorders In Children And Adolescents, André Zugman, Anderson M. Winkler, Daniel Samuel Pine

School of Medicine Publications and Presentations

Purpose of review:

Anxiety disorders are some of the most common psychiatric diagnoses in children and adolescents, but attempts to improve outcome prediction and treatment have stalled. This review highlights recent findings on neural indices related to fear and anxiety that provide novel directions for attempts to create such improvements.

Recent findings:

Stimuli capable of provoking fear engage many brain regions, including the amygdala, medial prefrontal cortex, hippocampus, and bed nucleus of the stria terminalis. Studies in rodents suggest that sustained, low-level threats are particularly likely to engage the bed nucleus of the stria terminalis, which appears to malfunction in …

Ptsd As An Endothelial Disease: Insights From Covid-19, Adonis Sfera, Carolina Osorio, Leah Rahman, Carlos M. Zapata Martín Del Campo, Jose Campo Maldonado, Nyla Jafri, Michael Cummings, Steve Maurer, Zisis Kozlakidis

School of Medicine Publications and Presentations

SARS-CoV-2 virus, the etiologic agent of COVID-19, has affected almost every aspect of human life, precipitating stress-related pathology in vulnerable individuals. As the prevalence rate of posttraumatic stress disorder in pandemic survivors exceeds that of the general and special populations, the virus may predispose to this disorder by directly interfering with the stress-processing pathways. The SARS-CoV-2 interactome has identified several antigens that may disrupt the blood-brain-barrier by inducing premature senescence in many cell types, including the cerebral endothelial cells. This enables the stress molecules, including angiotensin II, endothelin-1 and plasminogen activator inhibitor 1, to aberrantly activate the amygdala, hippocampus, and …

The Mechanism And Pattern Of Injuries Of Undocumented Immigrants Crossing The Texas-Mexico Border Along The Rio Grande Valley, Carlos H. Palacio, Bianca Cruz, Cheryl Vanier, Jose Cano, Bradford G. Scott

School of Medicine Publications and Presentations

Background

Apprehensions of undocumented immigrants in the Rio Grande Valley sector of the U.S.-Mexico border have grown to account for nearly half of all apprehensions at the border. The purpose of this study is to report the prevalence, mechanism, and pattern of traumatic injuries sustained by undocumented immigrants who crossed the U.S.-Mexico border at the Rio Grande Valley sector over a span of 5 years and were treated at a local American College of Surgeons verified Level II trauma center.

Methods

A retrospective chart review was conducted from January 2014 to December 2019. Demographics, comorbidities, injury severity score (ISS), mechanism …

Genz And Mendell-Elston Estimation Of The High-Dimensional Multivariate Normal Distribution, Lucy Blondell, Mark Kos, John Blangero, Harald H. H. Goring

School of Medicine Publications and Presentations

Statistical analysis of multinomial data in complex datasets often requires estimation of the multivariate normal (MVN) distribution for models in which the dimensionality can easily reach 10–1000 and higher. Few algorithms for estimating the MVN distribution can offer robust and efficient performance over such a range of dimensions. We report a simulation-based comparison of two algorithms for the MVN that are widely used in statistical genetic applications. The venerable Mendell- Elston approximation is fast but execution time increases rapidly with the number of dimensions, estimates are generally biased, and an error bound is lacking. The correlation between variables significantly affects …

Impact Of Covid-19 On Otolaryngology Literature, Yeshwant R. Chillakuru, Eleanor F. Gerhard, Timothy Shim, Samuel H. Selesnick, Lawrence R. Lustig, John H. Krouse, Ehab Y. Hanna, Timothy L. Smith, Edward W. Fisher, Joseph E. Kerschner, Ashkan Monfared

School of Medicine Publications and Presentations

Objective

To understand the effect of the COVID-19 pandemic on the volume, quality, and impact of otolaryngology publications.

Methods

Fifteen of the top peer-reviewed otolaryngology journals were queried on PubMed for COVID and non-COVID related articles from April 1, 2020 - March 31, 2021 (pandemic period) and pre-COVID articles from the year prior. Information on total number of submissions and rate of acceptance were collected from seven top-ranked journals.

Results

Our PubMed query returned 759 COVID articles, 4885 non-COVID articles, and 4200 pre-COVID articles, corresponding to a 34% increase in ENT publications during the pandemic period. Meta-analysis/reviews and miscellaneous publication …

Isolated Diastolic Hypertension In The Idaco Study: An Age-Stratified Analysis Using 24-Hour Ambulatory Blood Pressure Measurements, John W. Mcevoy, Wen-Yi Yang, Lutgarde Thijs, Zhen-Yu Zhang, Jesus D. Melgarejo, José Boggia, Tine W. Hansen, Kei Asayama, Takayoshi Ohkubo, Gladys E. Maestre

School of Medicine Publications and Presentations

The prognostic implications of isolated diastolic hypertension (IDH), as defined by 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines, have not been tested using ambulatory blood pressure (BP) monitor thresholds (ie, 24-hour mean systolic BP ≥75 mm Hg). We analyzed data from 11 135 participants in the IDACO (International Database on Ambulatory Blood Pressure in Relation to Cardiovascular Outcomes). Using 24-hour mean ambulatory BP monitor values, we performed Cox regression testing independent associations of IDH with death or cardiovascular events. Analyses were conducted in the cohort overall, as well as after age stratification (≥50 years). The median age …