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Adding Psychotherapy To The Naltrexone Treatment Of Alcohol Use Disorder: Metaanalytic Review, Rizwan A. Ahmed, Vijaya P. Kotapati, Ali M. Khan, Nuzhat Hussain, Mudasar Hussain, Sara Dar, Jeevan Kumar, Gulshan A. Begum, Michael Esang, Navjot Brainch, Saeed Ahmed
Adding Psychotherapy To The Naltrexone Treatment Of Alcohol Use Disorder: Metaanalytic Review, Rizwan A. Ahmed, Vijaya P. Kotapati, Ali M. Khan, Nuzhat Hussain, Mudasar Hussain, Sara Dar, Jeevan Kumar, Gulshan A. Begum, Michael Esang, Navjot Brainch, Saeed Ahmed
School of Medicine Publications and Presentations
Background
It remains unclear if naltrexone combined with psychotherapy is superior to naltrexone alone in treating alcohol use disorders (AUD). The current meta-analysis examined the hypothesis that psychotherapy is a significant moderator that influences AUD-related outcomes and that naltrexone combined with psychotherapy is associated with significantly better AUD-related outcomes than naltrexone alone.
Methods
A total of 30 studies (Nnaltrexone = 2317; Nplacebo = 2056) were included. Random effects model meta-analyses were carried out for each of the studied outcomes. Subsequently, the random effects model pooled estimates from studies with and without psychotherapy were compared using a Wald test. A mixed-effect …