Medicine and Health Sciences Commons^™

Optimal Echo Time For Functional Mri Of The Infant Brain Identified In Response To Noxious Stimulation, Sezgi Goksan, Caroline Hartley, Samuel A. Hurley, Anderson M. Winkler, Eugene P. Duff, Mark Jenkinson, Richard Rogers, Stuart Clare, Rebeccah Slater

School of Medicine Publications and Presentations

Purpose: Blood oxygen level dependent (BOLD) brain activity, measured using functional MRI (fMRI), is dependent on the echo time (TE) and the reversible spin-spin relaxation time constant ( T2*) that describes the decay of transverse magnetization. Use of the optimal TE during fMRI experiments allows maximal sensitivity to BOLD to be achieved. Reports that T2* values are longer in infants (due to higher water concentrations and lower lipid content) have led to the use of longer TEs during infant fMRI experiments; however, the optimal TE has not been established.

Methods: In this study, acute experimental mildly noxious stimuli were applied …

Magnetic Nanoformulations For Prostate Cancer, Pallabita Chowdhury, Allison M. Roberts, Sheema Khan, Bilal B. Hafeez, Subhash C. Chauhan, Meena Jaggi, Murali M. Yallapu

School of Medicine Publications and Presentations

Magnetic nanoparticles (MNPs) play a vital role for improved imaging applications. Recently, a number of studies demonstrate MNPs can be applied for targeted delivery, sustained release of therapeutics, and hyperthermia. Based on stable particle size and shape, biocompatibility, and inherent contrast enhancement characteristics, MNPs have been encouraged for pre-clinical studies and human use. As a theranostic platform development, MNPs need to balance both delivery and imaging aspects. Thus, this review provides significant insight and advances in the theranostic role of MNPs through the documentation of unique magnetic nanoparticles used in prostate cancer, their interaction with prostate cancer cells, in vivo …