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The Role Of Autophagy During Myocardial Ischemia/Reperfusion Injury, Aloysius Ibe, Alisa Kim, Hannah Kim, Marquese Daniels, Lindon H. Young, Robert J. Barsotti, Qian Chen
The Role Of Autophagy During Myocardial Ischemia/Reperfusion Injury, Aloysius Ibe, Alisa Kim, Hannah Kim, Marquese Daniels, Lindon H. Young, Robert J. Barsotti, Qian Chen
Research Day
Autophagy is a housekeeping process to remove damaged cytoplasmic constituents. However, a debate persists on whether autophagy is beneficial or detrimental when an ischemic/reperfusion (I/R) insult occurs in the heart. This study tested the effects of autophagy enhancers (e.g. rapamycin and trehalose) and autophagy inhibitor (e.g. 3-methyladenine) on heart function and infarct size after global I (30 minutes) and R (45 minutes) when given prior to ischemia (pre-treatment) or at the beginning of reperfusion (post-treatment). We found that Rapamycin (25nM) pre-treatment and post-treatment significantly restored final left ventricular developed pressure (LVDP) to 75.4±9.1% and 60±5% of initial baseline respectively (both …