Medicine and Health Sciences Commons^™

Discovery Of Genetic Pleiotropy For Obesity And Inflammation And Mediation In Identified Variants Through Obesity-Related Pathways, Yiqian Wenren

Public Health Theses

Genetic data suggest that obesity and inflammation shared a portion of their genetic architectures. Meanwhile, epidemiologic data suggest a causal link between obesity and inflammation. Therefore, we hypothesized that there are variants in the human genome that display pleiotropy for obesity and inflammation and that the effects of at least some of those variants could be mediated by obesity-related pathways. To test these hypotheses, we conducted univariate genome-wide association analyses of obesity-related traits (BMI and WHRadjBMI) and inflammation (CRP) in the UK Biobank (n= 291,396 Caucasian subjects), searched for overlapping signals, fine-mapped the regions to identify putative causal SNPs, and …

United States Long-Term Trends In Adult Bmi From 1959 To 2018 By Income, Education, And Race/Ethnicity, Julia Banas

Public Health Theses

Obesity prevalence has increased dramatically since the 1950s. While cross-sectional comparisons across racial, ethnic, and socioeconomic groups are abundant, there is less work on long-term trends. We assessed trends in average adult body mass index (BMI) in the United States by income, education, and racial/ethnic groups from 1959 to 2018 using the National Health and Nutrition Examination Survey, which assesses repeated cross-sectional, representative samples of the United States population. Height, weight, income, education, and race variables were extracted from raw data files; income data was converted to constant dollars prior to analysis. BMI was calculated from height and weight measurements. …

So You Think You Can Exercise: The Gap Between Exercise Confidence And Physical Activity Among Samoan Adults, Diksha Brahmbhatt

Public Health Theses

Samoa is experiencing one of the highest prevalence of overweight and obesity in the world, placing its population at increased risk of developing several noncommunicable diseases including type 2 diabetes and cardiovascular disease. The role of physical activity in reducing the burden of these diseases and overweight is well-established. Exercise self-efficacy or confidence is a predictor, if not determinant, of recreational physical activity. The purpose of this study, therefore, is to assess the relationship between exercise confidence and levels of recreational physical activity among Samoan adults. We confirm that exercise confidence is correlated with time spent exercising. However, despite considerable …

Postpartum Weight Trajectories In A Cohort Of 127 Samoan Women: Does Breastfeeding Protect Against Postpartum Weight Retention?, Grace Castillo

Public Health Theses

Rising global obesity rates impact every aspect of health, including maternal-fetal health. Samoa has a disproportionate burden of obesity, with more than half of Samoan women entering pregnancy obese. Given Samoan women’s high parity (4), postpartum weight retention (PPWR) may be a significant source of weight gain over women’s lifetimes. Little is currently known about PPWR among Samoan women, so this analysis sought to document PPWR trajectories, assess factors – like breastfeeding -- associated with PPWR. Data of 127 mother-infant dyads from the 2017 Foafoaga O le Ola cohort were used in analysis. Researchers collected demographic and lifestyle data, as …

Recalled Fruit And Vegetable Intake While Growing Up And Its Association With Adult Fruit And Vegetable Intake Among U.S. Adults - Analysis Of The Food Attitudes And Behaviors Survey, Mary D. Hill

Public Health Theses

ABSTRACT

MARY D. HILL

Recalled fruit and vegetable intake while growing up and its association with adult fruit and vegetable intake among U.S. adults – analysis of the food attitudes and behaviors survey

(Under the direction of DR. KYMBERLE STERLING)

High dietary intake of fruits and vegetables (FVs) is associated with a lower risk for chronic disease including certain cancers, optimal child growth, and weight management. More than 72 million U.S. adults are obese; therefore, fruit and vegetable intake is important in weight management. Using data from the Food Attitude and Behavior survey, this study will address the following questions: …

Elevated Bmi-Associated Characteristics Of Patients With Invasive Mrsa Infection In The Atlanta, Georgia Metro Area, 2005-2008, Lauren R. Lorentzson

Public Health Theses

INTRODUCTION: National obesity rates are leading to higher rates of Type 2 Diabetes, increasing the number of people at risk of invasive infections with Methicillin Resistant Staphylococcus aureus (iMRSA) upon onset of ESRD and hemodialysis. However, an association between adiposity and risk of iMRSA has not been researched. AIM: The purpose of this study is to describe the epidemiological characteristics of an iMRSA cohort in the Atlanta metro area between 2005-2008; to examine BMI-related health outcomes within the cohort; and to compare proportions of BMI categories in this cohort to BRFSS data. METHODS: Surveillance data collected by the CDC EIP …

Epidemiology Of Adiposity In Childbearing Ghanaian Women, Emma Roselyne Konan Mrs

Public Health Theses

ABSTRACT BACKGROUND: The prevalence of adiposity (overweight and obesity) is increasing in among Ghanaian women. The disparity between urban and rural Ghanaian women in adiposity is seldom described due to data paucity. The purpose of this study was to provide a comparative analysis between urban and rural women in regards to the socio-demographic factors associated with adiposity. METHODS: The analyses used cross-sectional data from the Ghana Demographic Health Survey involving child bearing women ages14 to 49 years old. The eligible population comprised 4848 non-pregnant women (2023 from urban and 2825 from rural areas). Residence-specific (urban versus rural) associations between selected …

Implications In Using Monte Carlo Simulation In Predicting Cardiovascular Risk Factors Among Overweight Children And Adolescents, Stephen Matthew Heimbigner

Public Health Theses

The prevalence of overweight and obesity among children and adolescents has increased considerably over the last few decades. As a result, increasing numbers of American children are developing multiple risk factors for cardiovascular disease, type II diabetes, hyperinsulinemia, hypertension, dyslipidemia and hepatic steatosis. This thesis examines the use of Monte Carlo computer simulation for understanding risk factors associated with childhood overweight. A computer model is presented for predicting cardiovascular risk factors among overweight children and adolescents based on BMI levels. The computer model utilizes probabilities from the 1999 Bogalusa Heart Study authored by David S. Freedman, William H. Dietz, Sathanur …

Obesity And The Built Environment In Twenty-Six Rural Georgia Counties: An Analysis Of Physical Activity, Fruit And Vegetable Consumption, And Environmental Factors., Kathleen Elizabeth Sobush

Public Health Theses

This study assesses environmental factors in the exercise and food environment, demographic factors, physical activity behavior, and fruit and vegetable consumption in 26 rural Georgia counties. The purpose of the study is to identify environmental indicators of physical activity and fruit and vegetable consumption; to see what agencies in Georgia, if any, are collecting these types of data systematically throughout the state; and, to analyze potential relationships between environmental factors and health behaviors. Physical activity and fruit and vegetable consumption were derived from the Georgia Behavioral Risk Factor Surveillance System (2001, 2002, 2003, and 2005). Demographic data were from the …