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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
Comments On "Transcriptional Profiling Of Oral Squamous Cell Carcinoma Using Formalin-Fixed Paraffin-Embedded Samples" By Saleh Et Al., Oral Oncol 46 (2010) 379-386 Reply, Rosnah Binti Zain
Comments On "Transcriptional Profiling Of Oral Squamous Cell Carcinoma Using Formalin-Fixed Paraffin-Embedded Samples" By Saleh Et Al., Oral Oncol 46 (2010) 379-386 Reply, Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Dear Editor, We thank Rentoft and colleagues for commenting on our paper “Transcriptional profiling of oral squamous cell carcinoma using formalin-fixed paraffin-embedded samples”, and agreeing that formalin-fixed paraffin embedded (FFPE) tissue specimens can be used for gene expression studies using microarrays, to identify genes that are significantly involved in oral carcinogenesis. The similarities and high concordance between the study by Rentoft et al. [1] and ours [2] is comforting and clearly supports the use of FFPE tissues in such experiments. More importantly, these studies act as independent validation for one another and strongly suggests that genes that were found to …
Genetic Polymorphisms And Risk Of Oral Cancer, Zaini Z. M., Karen-Ng L. P., Cheong S. C., Gurdeep S. M., Yuen K. M., Tay K. K., Jalil N., Ismail S. M., Jallaluddin A., Rosnah Binti Zain
Genetic Polymorphisms And Risk Of Oral Cancer, Zaini Z. M., Karen-Ng L. P., Cheong S. C., Gurdeep S. M., Yuen K. M., Tay K. K., Jalil N., Ismail S. M., Jallaluddin A., Rosnah Binti Zain
Prof. Dr. Rosnah Binti Zain
Objectives: This study was done to investigate the role of single nucleotide polymorphisms(SNPs) within genes of phase I (CYP1A1) and phase II (GSTM1, GSTT1,GSTP1) of the xenobiotic metabolism and its association with oral cancer risk.Methods: An unmatched case-control study was conducted using 207 newly diagnosed oral cancer patients and 117 non-cancer subjects selected from the OCRCC database. Peripheral blood was obtained from consented individuals and the CYP1A1, GSTM1, GSTT1 and GSTP1 genotypes were determined using polymerase chain reaction (PCR) and restriction enzyme digestion (RFLP). Simple and multiple logistic regression yielding odds ratio (OR and aOR) were employed to measure the …
Selected Transcriptome Profiles Of Oral Cancer Suggestive Of Field Cancerisation Using Second Generation Sequencing, Rosnah Binti Zain, Anwar A., Karen-Ng L. P., Cheong S. C., Zaini Z., Prepagaran N., Hercus R., Idris N. M., Saidin A., Chia J. Y., Merican A. F., Abraham M. T., Tay K. K., Mustaffa W. M. W., Norain A. T., Rahman Z. A. A., Jallaludin A.
Selected Transcriptome Profiles Of Oral Cancer Suggestive Of Field Cancerisation Using Second Generation Sequencing, Rosnah Binti Zain, Anwar A., Karen-Ng L. P., Cheong S. C., Zaini Z., Prepagaran N., Hercus R., Idris N. M., Saidin A., Chia J. Y., Merican A. F., Abraham M. T., Tay K. K., Mustaffa W. M. W., Norain A. T., Rahman Z. A. A., Jallaludin A.
Prof. Dr. Rosnah Binti Zain
Objectives: To characterize differential gene expression between oral cancerous tissues and the normal mucosal tissues of oral cancer patients and oral mucosal tissues of cancer free patients using second generation sequencing. Methods: Five fresh frozen oral cancer tissue samples from smoking patients, with 2 samples of proximal normal were included in this study. An additional 8 samples consisting of normal oral mucosal tissues from the alveolar mucosa of non-cancer patients who had their wisdom tooth removed where 4 were smokers and another 4 were non-smokers was also included. The tissues and socio-demographic information were obtained from the Malaysian Oral Cancer …
Transcriptional Profiling Of Oral Squamous Cell Carcinoma Using Formalin-Fixed Paraffin-Embedded Samples, Saleh A., Rosnah Binti Zain, Hussaini H., Ng F., Tanavde V., Hamid S., Chow A. T., Lim G. S., Abraham M. T., Teo S. H., Cheong S. C.
Transcriptional Profiling Of Oral Squamous Cell Carcinoma Using Formalin-Fixed Paraffin-Embedded Samples, Saleh A., Rosnah Binti Zain, Hussaini H., Ng F., Tanavde V., Hamid S., Chow A. T., Lim G. S., Abraham M. T., Teo S. H., Cheong S. C.
Prof. Dr. Rosnah Binti Zain
Despite the advances in cancer treatment, the 5-year survival rate for oral cancer has not changed significantly for the past 40 years and still remains among the worst of all anatomic sites. Gene expression microarrays have been used successfully in the identification of genetic alterations in cancer development, however, these have hitherto been limited by the need for specimens with good quality intact RNA. Here, we demonstrated the use of formalin-fixed paraffin-embedded tissues in microarray experiments to identify genes differentially expressed between cancerous and normal oral tissues. Forty-three tissue samples were macrodissected and gene expression analyses were conducted using the …
A Bootstrap-Anfis Framework For Oral Cancer Prognosis Based On Clinical And Genomic Markers, Chang S. W., Sameem A. K., Rosnah Binti Zain, Merican A. F. M. A.
A Bootstrap-Anfis Framework For Oral Cancer Prognosis Based On Clinical And Genomic Markers, Chang S. W., Sameem A. K., Rosnah Binti Zain, Merican A. F. M. A.
Prof. Dr. Rosnah Binti Zain
The incidence of oral cancer is high in Malaysia especially for those of Indian ethnic origin. In this research, an oral cancer prognosis prediction model will be developed by using Bootstrap-ANFIS techniques. The aim of this research is to improve the prediction of oral cancer survival and to identify the key clinical and genomic markers for the survival prediction of oral cancer. The proposed model is designed to handle small medical dataset with limitations in terms of time, cost and tissue samples.
Inherent Differential Propensity Of Dental Pulp Stem Cells Derived From Human Deciduous And Permanent Teeth, Govindasamy V., Abdullah A. N., Ronald V. S., Musa S., Aziz Z. A. C. A., Rosnah Binti Zain, Totey S., Bhonde R. R., Kasim N. H. A.
Inherent Differential Propensity Of Dental Pulp Stem Cells Derived From Human Deciduous And Permanent Teeth, Govindasamy V., Abdullah A. N., Ronald V. S., Musa S., Aziz Z. A. C. A., Rosnah Binti Zain, Totey S., Bhonde R. R., Kasim N. H. A.
Prof. Dr. Rosnah Binti Zain
Introduction: Lately, several new stem cell sources and their effective isolation have been reported that claim to have potential for therapeutic applications. However, it is not yet clear which type of stem cell sources are most potent and best for targeted therapy. Lack of understanding of nature of these cells and their lineagespecific propensity might hinder their full potential. Therefore, understanding the gene expression profile that indicates their lineage-specific proclivity is fundamental to the development of successful cell-based therapies. Methods: We compared proliferation rate, gene expression profile, and lineage-specific propensity of stem cells derived from human deciduous (SCD) and permanent …