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Full-Text Articles in Medicine and Health Sciences
Possible Molecular Mechanisms Underlying Age-Related Cardiomyocyte Apoptosis In The F344xbn Rat Heart, Sunil Kakarla, Kevin Rice, Anjaiah Katta, Satyanarayana Paturi, Miaozong Wu, Madhukar Kolli, Saba Keshavarzian, Kamran Manzoor, Paulette Wehner, Eric Blough
Possible Molecular Mechanisms Underlying Age-Related Cardiomyocyte Apoptosis In The F344xbn Rat Heart, Sunil Kakarla, Kevin Rice, Anjaiah Katta, Satyanarayana Paturi, Miaozong Wu, Madhukar Kolli, Saba Keshavarzian, Kamran Manzoor, Paulette Wehner, Eric Blough
Paulette S. Wehner
Despite advances in treatment, age-related cardiac dysfunction still remains a leading cause of cardiovascular death. Recent data have suggested that increases in cardiomyocyte apoptosis may be involved in the pathological remodeling of heart. Here, we examine the effects of aging on cardiomyocyte apoptosis in 6-, 30-, and 36-month-old Fischer344xBrown Norway F1 hybrid rats (F344XBN). Compared with 6-month hearts, aged hearts exhibited increased TdT-mediated dUTP nick end labeling–positive nuclei, caspase-3 activation, caspase-dependent cleavage of α-fodrin and diminished phosphorylation of protein kinase B/Akt (Thr 308). These age-dependent increases in cardiomyocyte apoptosis were associated with alterations in the composition of the cardiac dystrophin …
Age-Associated Changes In Hearts Of Male Fischer 344/Brown Norway F1 Rats, Ernest Walker, Michael Nillas, Elsa Mangiarua, Sylvestre Cansino, Ryan Morrison, Romaine Perdue, William Triest, Gary Wright, Mark Studeny, Paulette Wehner, Kevin Rice, Eric Blough
Age-Associated Changes In Hearts Of Male Fischer 344/Brown Norway F1 Rats, Ernest Walker, Michael Nillas, Elsa Mangiarua, Sylvestre Cansino, Ryan Morrison, Romaine Perdue, William Triest, Gary Wright, Mark Studeny, Paulette Wehner, Kevin Rice, Eric Blough
Paulette S. Wehner
Aging is associated with left ventricular hypertrophy, dilatation, and fibrosis of the heart. The Fischer 344/Brown Norway F1 (F344/BNF1) rat is recommended for age-related studies by the National Institutes on Aging because this hybrid rat lives longer and has a lower rate of pathological conditions than inbred rats. However, little is known about age-associated changes in cardiac and aortic function and structure in this model. This study evaluated age-related cardiac changes in male F344/BNF1 rats using ECHO, gross, and microscopic examinations. Rats aged 6-, 30-, and 36-mo were anesthetized and two-dimensional ECHO measurements, two-dimensional guided M-mode, Doppler M-mode, and other …