Medicine and Health Sciences Commons^™

Is Pitolisant Effective In Reducing Excessive Daytime Sleepiness And Cataplexy In Adults With Narcolepsy?, Christina M. Michael

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not pitolisant is effective in reducing excessive daytime sleepiness and cataplexy in adults with narcolepsy.

Study Design: Review of two randomized control trials (RCTs) published in 2013 and 2017, and one prospective, placebo-controlled, single-blind study published in 2008.

Data Sources: All articles were published in English and taken from peer-reviewed journals, which were found using the PubMed database.

Outcomes Measured: The outcomes of investigation measured include excessive daytime sleepiness (EDS) assessed by change in Epworth Sleepiness Scale (ESS) score, and cataplexy rate calculated from recorded cataplexy attacks …

Are Inverse Agonists Of The Histamine H3 Receptor Effective In Reducing Excessive Daytime Sleepiness (Eds) In Individuals With Sleep Disorders?, Kelly-Ann Peters

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this systematic review is to determine whether or not “Are inverse agonists of the Histamine H3 receptor effective in reducing excessive daytime sleepiness (EDS) in individuals with sleep disorders?”

DESIGN: Review of two randomized controlled trials and one cross-sequential pilot study. All studies were primary sources, published in the English language and from 2008-2017.

DATA SOURCES: A single-blind, placebo controlled, cross-sequential study comparing an H3 inverse agonist to placebo in narcoleptics. Two randomized, double-blind, placebo controlled studies; one in narcoleptic patients and one in obstructive sleep apnea (OSA) patients. All studies found using PubMed and Cochrane …

Is Modafinil (Provigil®) Effective In Improving Cognitive Function In Adults With Narcolepsy?, Stephanie V. Bui

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not modafinil (Provigil®) is effective in improving cognitive function in adults with narcolepsy.

STUDY DESIGN: Review of all English language primary randomized controlled trials from 1996 to 2010.

DATA SOURCES: Double-blind, randomized controlled trials that compared modafinil (Provigil®) to a visually matched placebo were found using OVID, MEDLINE, and Cochrane Databases.

OUTCOME(S) MEASURED: Each of the three trials assessed the effect of modafinil on cognitive and executive function by Low-Resolution Brain Electromagnetic Tomography (LORETA), and the following assessment tools: Epworth Sleepiness Scale (ESS), Multiple Sleep …