Medicine and Health Sciences Commons^™

Is Raloxifene Effective As An Adjunctive Schizophrenia Medication In Reducing Schizophrenia Symptoms In Women With Diagnosed Schizophrenia?, Alexandra E. Wilcox

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not raloxifene is effective as an adjunctive schizophrenia medication in reducing schizophrenia symptoms in women with diagnosed schizophrenia.

STUDY DESIGN: A review of three peer-reviewed studies published between 2014 and 2016.

DATA SOURCES: Three randomized control trials. Using PubMed and Cochrane Collaboration, studies were chosen if they were peer-reviewed, related to the topic question, published after 2014, and if they had results containing POEMs.

OUTCOMES MEASURED: Decrease in schizophrenia Symptoms, as measured by the Positive and Negative Syndromes Scale (PANSS).

RESULTS: Two studies found a statistically significant …

Does Metacognitive Training Improve The Quality Of Life In Patients With Schizophrenia?, Amy Wei

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not “Does metacognitive training (MCT) improve the quality of life in patients with schizophrenia?”

Study Design: Systematic review of three randomized controlled trials (RCTs) published in peer-reviewed journals between 2010-2014, all in the English language; two of which were published in 2014 and one in 2010.

Data Sources: Three randomized controlled trials found using PubMed.

Outcomes Measured: Quality of life with a focus on social relationships was assessed using the Brief Quality of Life Questionnaire of the World Health Organization (WHOQOL-BREF) or Quality of Life Scale (QLS). …

Is The Use Of Omega-3 Polyunsaturated Fatty Acids As Adjunctive Therapy Effective In Reducing Symptom Severity In Adult Schizophrenia Patients?, Desiree Goenaga

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not the use of omega-3 polyunsaturated fatty acids (PUFA) as adjunctive therapy is effective in reducing symptom severity in adult schizophrenia patients.

STUDY DESIGN: A selective review of three peer-reviewed, double-blind, randomized, placebo-controlled trials published between the years of 2008 and 2016.

DATA SOURCES: All three randomized control trials were published in English and were selected from peer-reviewed journals via EmBase and PubMed based on relevance to the clinical question posed above and that the outcomes measured in the studies mattered to patients, or were “patient oriented.” …

Is Aristada (Aripiprazole Lauroxil) A Safe And Effective Treatment For Schizophrenia In Adult Patients?, Kyle J. Knowles

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Is Aristada (aripiprazole lauroxil) a safe and effective treatment for schizophrenia in adult patients?”

STUDY DESIGN: Review of three randomized controlled studies. All three trials were conducted between 2014 and 2015.

DATA SOURCES: One randomized, controlled trial and two randomized, controlled, doubleblind trials found via Cochrane Library and PubMed.

OUTCOMES MEASURED: The outcomes that were measured include adverse events (pain at injection site, insomnia, headache, toothache, abdominal discomfort, constipation, diarrhea, akathisia, back pain, dyskinesia, dystonia, nasopharyngitis) measured by vital signs, physical examination, …

Does The Addition Of Piracetam Safely And Effectively Improve Behavioral And Or Cognitive Functions In Schizophrenia?, Dieu Linh Nguyen

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective evidence based medicine (EBM) review is to determine whether or not the addition of piracetam safely and effectively improve behavioral and or cognitive functions in schizophrenia.

STUDY DESIGN: The selected review from all English language, primary literature sources that were published between 1979 and 1999.

DATA SOURCES: Three double blind randomized controlled trials (RCT) and one case controlled clinical study that compared piracetam to a visually matched placebo was selected and found using Medline, PubMed, Ebscohost, and Cochrane databases.

OUTCOMES MEASURED: Each of the trials assessed the effect of Piracetam on behavioral and …

Is Lurasidone More Safe And Effective In The Treatment Ofschizoaffective Disorder And Schizophrenia Than Other Commonanti-Psychotic Medications?, Megan M. Sisbarro

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not Lurasidone is more safe and effective in the treatment of schizoaffective disorder and schizophrenia than other common anti-psychotic medications. Study Design: Review of two English language randomized double-blinded controlled comparisons and one English language Randomized open-label parallel-group comparison. Data Sources: The randomized double-blinded controlled comparison studies and the randomized open-label parallel-group comparison were all found using PubMed and EBSCOhost databases. All three articles were published in peer-reviewed journals. Outcomes Measured: Participant withdrawal due to adverse effects and treatment failure, patient responses to MATRICS consensus cognitive battery, …

Is Animal Assisted Therapy Using Dogs An Effective Treatment For Positive And Negative Symptoms For Adult Inpatient Schizophrenics?, Brian Davidson

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Animal Assisted Therapy (AAT) using dogs is an effective treatment for positive and negative symptoms for adult inpatient schizophrenics.

STUDY DESIGN: Systematic review of 3 articles published in English in peer reviewed journals between 2005-2009

DATA SOURCES: Two randomized controlled trials and one allocation by minimization controlled trial comparing the effects of AAT using dogs on positive and negative symptoms of schizophrenia to control groups. All articles were found using PubMed and PROQuest

OUTCOMES MEASURED: Focused questionnaires were given before and after …