Medicine and Health Sciences Commons^™

Are Foot Orthoses Effective At Reducing Pain In Adults With Foot Osteoarthritis?, Jacob T. Kemmerer

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Are foot orthoses effective at reducing pain in adults with foot osteoarthritis?”

STUDY DESIGN: A review of two randomized controlled trials and one case series from peer-reviewed journals published between 2010 and 2016.

DATA SOURCES: Two randomized controlled trials and one case series were found using PubMed.

OUTCOME MEASURED: Reduction of the subject’s foot pain was the patient-oriented outcome measured in each of these three articles. The subject’s pain was scored on a Likert scale and evaluated at baseline and at 12 weeks to assess their …

Is Curcuma Effective For The Management Of Osteoarthritis Knee Pain?, Katherine Grinberg

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of the selective EBM review is to determine whether or not “Is Curcuma effective for the management of osteoarthritis knee pain?”

STUDY DESIGN: Systematic review of three randomized controlled trials (RCT) published in 2009, 2014, and 2016.

DATA SOURCES: Three RCTs studies were found using PubMed. All articles were published in reviewed journals and selected based on correlation to topic choice, date of publication, and evaluation of POEMs.

OUTCOMES MEASURED: The Western Ontario and McMaster Universities Arthritis Index (WOMAC) is a questionnaire that evaluates hip and knee osteoarthritis. The questions are divided into 3 subscales: pain, stiffness, …

Are Prp And Ha Injections Beneficial For Symptomatic Relief When Administered As Combination Therapy In Patients With Knee Osteoarthritis?, Saniya M. Ahmed

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Are PRP and HA injections beneficial for symptomatic relief when administered as combination therapy in patients with knee osteoarthritis?”

STUDY DESIGN: A systematic review of two randomized control trials (RCTs) and one case series published between 2016-2018.

DATA SOURCES: Sources were found using PubMed and Cochrane. Sources were selected based on patient-oriented evidence of therapeutic effects from HA and PRP injections as monotherapy and combination therapy in symptomatic relief for patients with knee osteoarthritis.

OUTCOMES MEASURED: Patient-reported pain score was recorded after treatment using Visual Analog …

Are Curcuminoids Effective In Reducing Pain In Adults With Knee Osteoarthritis?, Lauren Tanna

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not curcuminoids are effective in reducing pain in adults with knee osteoarthritis.

STUDY DESIGN: This is a systematic review which evaluates three randomized controlled trials (RCT’s) published in peer reviewed journals between 2016-2018.

DATA SOURCES: The data sources used for this review were found using PubMed and Cochrane Library. Data was chosen based on relevance to the clinical question and if patient-oriented evidence that matters (POEMS) were included.

OUTCOMES MEASURED: All three studies measured curcuminoids and its effects on pain reduction in adults with knee osteoarthritis using …

Does Phonophoresis Using Nsaids Reduce Osteoarthritis Knee Pain?, Amber R. Wobma

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not phonophoresis using NSAIDs reduces osteoarthritis knee pain.

Study Design: Systematic review of three double-blind randomized controlled trials published between the years 2013 and 2018.

Data Sources: Published peer-reviewed articles obtained through PubMed and Cochrane Collaboration. Articles were selected based on relevance to my clinical question and if they included patient-oriented outcomes.

Outcomes Measured: Pain severity was self-reported by patients using a visual analog scale (VAS) on a continuum of 0-100; 0 representing no pain at all and 100 representing the worst pain imaginable. Participants in all …

Is Hyaluronic Acid Intra-Articular Injection Better Than Corticosteroid Intra Articular Injection At Reducing Pain In Patients With Knee Osteoarthritis?, Madison Cohen

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not “Hyaluronic Acid intra articular injection is better than Corticosteroid intra articular injection at reducing pain in patients with knee osteoarthritis.”

STUDY DESIGN: Review of three double-blind, randomized control trials published between 2014 and 2016. All studies were published in English language in peer reviewed journals.

DATA SOURCES: All three randomized control trials were found via PubMed.

OUTCOMES MEASURED: The primary outcomes measured by the patient and investigator being improvement of knee pain severity, knee function, and range of motion after hyaluronic acid intra articular (IA) injection …

Can Yoga Therapy Help To Decrease Osteoarthritis-Related Pain In Adults With Knee Osteoarthritis?, Justin Mahr

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not yoga therapy can help to decrease osteoarthritis-related pain in adults with knee osteoarthritis.

Study Design: A review of two randomized controlled trials and one randomized control trial pilot study that were published in English in peer-reviewed journals after 2007.

Data Sources: All articles were selected from peer-reviewed journals and found via PubMed.

Outcome(s) Measured: Patient perception of pain using either a Walking Numerical Rating Scale (WNRS) and/or a Western Ontario and McMaster Universities OA Index scale (WOMAC).

Results: All three studies …

Is Tanezumab More Effective Than A Placebo In Reducing Pain In Patients With Osteoarthritis?, Nesdi Rivera

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not, “Is tanezumab more effective than a placebo in reducing pain in patients with osteoarthritis?”

STUDY DESIGN: Review of three randomized, double-blind, placebo controlled trials from 2012 to 2015.

DATA SOURCES: Three double-blind randomized clinical trials (RCTs) were found using PubMed, and selected based on outcomes measured and relevance to the objective.

OUTCOMES MEASURED: Clinical outcomes of knee and hip osteoarthritis pain were measured using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain scale to assess pain before and after treatment with tanezumab and comparison. …

Is Weight Loss An Effective Treatment Of Pain Symptoms Related To Knee Joint Osteoarthritis In Obese Adults?, Samantha Sokol

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not weight loss is an effective treatment of pain symptoms related to knee joint osteoarthritis in obese adults.

Study Design: Systematic review of 2 randomized-controlled trials and 1 cohort study. All three articles were published in English between 2011-2015.

Data Sources: Two randomized, un-blinded, controlled studies and one cohort found using Pubmed.

Outcomes Measured: Each study evaluated change in pain symptoms related to knee osteoarthritis in obese adults as compared to weight loss.

Results: Studies showed that weight loss lead to a …

Is Viscosupplementation Effective In Reducing Osteoarthritis Knee Pain?, Amalia Antonoplos

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not viscosupplementation is effective in reducing osteoarthritis knee pain

STUDY DESIGN: Review of three randomized, double blind, placebo control trials between 2009- 2010

DATA SOURCES: Three randomized, double blind, placebo control trials were found via PubMed and NCBI

OUTCOMES MEASURED: Each randomized control trial measured knee pain and/or patient satisfaction following their intervention (placebo or hyaluronic acid) in patients with knee osteoarthritis, which was measured via WOMAC pain scale and patient global assessment forms.

RESULTS: (P<0.05) for change in pain at 14-26 weeks after injection (NNT=6- 8 for Chevalier et al and 4 for Kul-Panza & Berker). Patient satisfaction was higher in the experimental groups as compared to the control with conclusions of NNT between 11 and 20 for Chevalier et al and Kul-Panza & Berker respectively. Chavelier et al found adverse events such as arthralgias and joint effusion in <10% of their study population (NNH=39). No dichotomous data was presented in Diacoglu et al; however an ANOVA was deemed statistically significant (p<0.01).

CONCLUSION: Review of these articles concludes that the use of hyaluronic …

Is Ayurvedic Effective In Reducing Osteoarthritis Pain In Adults?, Reja Khan

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether or not Ayurvedic is effective in reducing osteoarthritis pain in adults.

Study Design: Review of three English language randomized controlled trials published between from 2004-2013.

Data Sources: Two double blind randomized controlled trials and one open label randomized controlled clinical trial were found using PubMed and Cochrane Library databases.

Outcomes Measured: To measure the effectiveness, the following parameters were utilized visual analog scale (VAS) reported by the patient to assess reduction in pain symptoms of osteoarthritis.

Results: Three randomized controlled studies results found that Ayurvedic medicine was beneficial …

Is Ginger Effective In Reducing Knee Pain In Adults With Osteoarthritis?, Joseph Heng

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this evidence based medicine review is to determine whether ginger is effective in reducing knee pain in adults with osteoarthritis.

Study Design: Three double blind, randomized controlled trials were reviewed and selected based on their relevance to the clinical question and their inclusion of patient oriented outcomes (POEMS).

Data Sources: Each study was obtained by searching Cochrane and PubMed database.

Outcomes Measured: The outcomes were measured using the Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) via Likert scale and Knee Pain rated via Knee injury and knee Osteoarthritis Outcome score (KOOS) questionnaire which is a …

Is The Addition Of Omega-3 Fatty Acids To Other Treatment Methods Effective In Reducing Pain In Adult Patients With Osteoarthritis?, Lisa C. Martin

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: Is the addition of Omega-3 fatty acids to other treatment methods effective in reducing pain in adult patients with osteoarthritis?

STUDY DESIGN: Review of three published, double blind, randomized controlled trials were used for this review and were selected based on their relevance to the clinical question.

DATA SOURCE: The most recent randomized control trials examining the relief of osteoarthritic pain with intake of omega-3 fatty acids in addition to traditional medical therapies were found using Medline, PubMed, and OVID databases.

OUTCOME MEASURED: Relief of osteoarthritic pain with the addition of omega-3 fatty acids to …

Does Autologous Conditioned Il-1 Antagonist (Acs) Reduce Pain In Patients With Oa Or Lumbar Radiculopathy?, Jonathan Mitchell

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: To determine whether or not Autologous conditioned IL-1 antagonist (ACS) reduces pain in patients with OA or lumbar radiculopathy.

STUDY DESIGN: Review of 3 randomized, double-blind controlled clinical trials in 2007, 2008, and 2009, all in English.

DATA SOURCES: Two randomized, double-blinded controlled clinical trials comparing the effectiveness of intra-articular injections of an autologous IL-1 receptor antagonist solution versus a control in OA and one randomized, double-blinded controlled clinical trials comparing autologous IL-1 receptor antagonist epidural injection versus 5 and 10 mg triamcinolone in patients with lumbar radiculopathy.

OUTCOMES MEASURED: The outcomes in this study …

Does Daily Intake Of Glucosamine Supplements Prevent The Need For Knee Replacements Later In Life For Adult Patients Predisposed To Osteoarthritis?, Nancy Helmy

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not daily intake of glucosamine supplements prevents the need for knee replacements later in life for adults predisposed to osteoarthritis.

STUDY DESIGN: Review of three English language primary randomized controlled trial studies published between 2001 and 2008

DATA SOURCES: Three double blind randomized control trials comparing glucosamine supplements to placebo were found using PubMed.

OUTCOMES MEASURED: Outcomes were measured using radiographic studies of the knees, joint space measurements, and symptoms were evaluated using Lequesne and WOMAC indexes.

RESULTS: The Reginster (2001) and Pavelka (2002) studies demonstrated no …

Is Valdecoxib An Effective Treatment Option To Improve Pain In Adults With Diagnosed Osteoarthritis Of The Hip Or Knee?, Karen A. Mcsorley

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Valdecoxib is an effective treatment option to improve pain in adults with osteoarthritis of the hip or knee.

STUDY DESIGN: This review consists of three randomized control trials; two were published in 2002 and the third in 2006.

DATA SOURCES: Sources were studies comparing groups taking Valdecoxib 10mg QD to placebo, which were found via Pubmed, MEDLINE, Ovid, and Cochrane databases.

OUTCOMES MEASURED: The three articles measured various outcomes: pain improvement, stiffness, physical improvement, adverse effects, and onset of analgesia during acute pain …

Is Phlogenzym Effective In Reducing Moderate To Severe Osteoarthritis Pain In Adults?, Vanessa K. Wood

PCOM Physician Assistant Studies Student Scholarship

OBJECTIVE: The objective of this selective EBM review is to determine whether or not Phlogenzym (or ERC) effective in reducing moderate to severe osteoarthritis pain in adults.

STUDY DESIGN: Review of three randomized controlled trials in the English language from 2001 to 2006.

DATA SOURCES: Two double blind RCTs and one open RCT was found using Cochrane Library EBM Online Database, Ovid Medline, and PubMed Online.

OUTCOMES MEASURED: Each of the three studies measured for pain at rest, pain with motion, and restricted function at baseline assessing efficacy using the Lequesne’s Algofunctional Index, visual analog scales, and …