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Full-Text Articles in Medicine and Health Sciences
Experimental Transmission Of Chronic Wasting Disease (Cwd) Of Elk (Cervus Elaphus Nelsoni), White-Tailed Deer (Odocoileus Virginianus), And Mule Deer (Odocoileus Hemionus Hemionus) To White-Tailed Deer By Intracerebral Route, A. N. Hamir, J. A. Richt, J. M. Miller, R. A. Kunkle, S. M. Hall, E. M. Nicholson, Katherine I. O'Rourke, J. J. Greenlee, E. S. Williams
Experimental Transmission Of Chronic Wasting Disease (Cwd) Of Elk (Cervus Elaphus Nelsoni), White-Tailed Deer (Odocoileus Virginianus), And Mule Deer (Odocoileus Hemionus Hemionus) To White-Tailed Deer By Intracerebral Route, A. N. Hamir, J. A. Richt, J. M. Miller, R. A. Kunkle, S. M. Hall, E. M. Nicholson, Katherine I. O'Rourke, J. J. Greenlee, E. S. Williams
Other Publications in Zoonotics and Wildlife Disease
To compare clinical and pathologic findings of chronic wasting disease (CWD) in a natural host, 3 groups (n = 5) of white-tailed deer (WTD) fawns were intracerebrally inoculated with a CWD prion of WTD, mule deer, or elk origin. Three other uninoculated fawns served as controls. Approximately 10 months postinoculation (MPI), 1 deer from each of the 3 inoculated groups was necropsied and their tissues were examined for lesions of spongiform encephalopathy (SE) and for the presence of abnormal prion protein (PrPd) by immunohistochemistry (IHC) and Western blot (WB). The remaining deer were allowed to live until …
Chronic Wasting Disease Of Elk: Transmissibility To Humans Examined By Transgenic Mouse Models, Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine I. O'Rourke, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Pertersen, Man-Sun Sy, Shu G. Chen, Pierluigi Gambetti
Chronic Wasting Disease Of Elk: Transmissibility To Humans Examined By Transgenic Mouse Models, Qingzhong Kong, Shenghai Huang, Wenquan Zou, Difernando Vanegas, Meiling Wang, Di Wu, Jue Yuan, Mengjie Zheng, Hua Bai, Huayun Deng, Ken Chen, Allen L. Jenny, Katherine I. O'Rourke, Ermais D. Belay, Lawrence B. Schonberger, Robert B. Pertersen, Man-Sun Sy, Shu G. Chen, Pierluigi Gambetti
Other Publications in Zoonotics and Wildlife Disease
Chronic wasting disease (CWD), a prion disease affecting free-ranging and captive cervids (deer and elk), is widespread in the United States and parts of Canada. The large cervid population, the popularity of venison consumption, and the apparent spread of the CWD epidemic are likely resulting in increased human exposure to CWD in the United States. Whether CWDis transmissible to humans, as has been shown for bovine spongiform encephalopathy (the prion disease of cattle), is unknown. We generated transgenic mice expressing the elk or human prion protein (PrP) in a PrP-null background. After intracerebral inoculation with elk CWD prion, two lines …