Medicine and Health Sciences Commons^™

Tudor Staphylococcal Nuclease Is A Docking Platform For Stress Granule Components And Is Essential For Snrk1 Activation In Arabidopsis, Emilio Gutierrez-Beltran, Pernilla H. Elander, Kerstin Dalman, Guy W. Dayhoff, Panagiotis N. Moschou, Vladimir N. Uversky, Jose L. Crespo, Peter V. Bozhkov

Molecular Medicine Faculty Publications

Tudor staphylococcal nuclease (TSN; also known as Tudor-SN, p100, or SND1) is a multifunctional, evolutionarily conserved regulator of gene expression, exhibiting cytoprotective activity in animals and plants and oncogenic activity in mammals. During stress, TSN stably associates with stress granules (SGs), in a poorly understood process. Here, we show that in the model plant Arabidopsis thaliana, TSN is an intrinsically disordered protein (IDP) acting as a scaffold for a large pool of other IDPs, enriched for conserved stress granule components as well as novel or plant-specific SG-localized proteins. While approximately 30% of TSN interactors are recruited to stress granules …