Medicine and Health Sciences Commons^™

Doctors' Perspectives On Psa Testing Illuminate Established Differences In Prostate Cancer Screening Rates Between Australia And The Uk: A Qualitative Study, K Pickles, S Carter, L Rychetnik, V Entwistle

Medical Papers and Journal Articles

Objectives: To examine how general practitioners (GPs) in the UK and GPs in Australia explain their prostate-specific antigen (PSA) testing practices and to illuminate how these explanations are similar and how they are different.

Design: A grounded theory study.

Setting: Primary care practices in Australia and the UK.

Participants: 69 GPs in Australia (n=40) and the UK (n=29). We included GPs of varying ages, sex, clinical experience and patient populations. All GPs interested in participating in the study were included.

Results: GPs’ accounts revealed fundamental differences in whether and how prostate cancer screening occurred in their practice and in the …

Predicting Low-Risk Prostate Cancer From Transperineal Saturation Biopsies, P Van Leeuwen, A Siriwardana, M Roobol, F Ting, D Nieboer, J Thompson, Warick Delprado, A Haynes, P Brenner, P Stricker

Medical Papers and Journal Articles

Introduction: To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC).

Materials and Methods: Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e., criteria 1–5, criterion 1 stringent (Gleason score 6 + ≤5mm total max core length PC + ≤3mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with ≤5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score ≤6 and total tumour volume <2.5mL, or Gleason score 7 with ≤5% grade 4 and total tumour volume <0.7 mL).

Results: 994 men who underwent RP were included. Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792. At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC.

Conclusions: Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference …