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Colonization Of The Pharyngeal Tonsil And Respiratory Tract Of The Gnotobiotic Pig By A Toxigenic Strain Of Pasteurella Multocida Type D, Mark R. Ackermann, N. F. Cheville, J. E. Gallagher
Colonization Of The Pharyngeal Tonsil And Respiratory Tract Of The Gnotobiotic Pig By A Toxigenic Strain Of Pasteurella Multocida Type D, Mark R. Ackermann, N. F. Cheville, J. E. Gallagher
Mark R. Ackermann
Seven-day-old gnotobiotic pigs were inoculated intranasally with Pasteurella multocida and euthanatized 2, 5, 9, and 14 days after inoculation. Tissues from the oropharynx and respiratory tract of pigs were cultured quantitatively and analyzed microscopically. Pigs remained afebrile and alert, except one that died of acute fibrinopurulent pneumonia. Pasteurella multocida was isolated in greatest numbers from the pharyngeal tonsils, but only in low numbers from turbinate, trachea, lung, spleen, and liver. Significant histologic changes were limited to the tonsil. Infected pigs developed mild tonsillitis with lymphocytic hyperplasia, and accumulation of cell debris and bacteria in crypts. Capsular antigens of P. multocida, …