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Articles 1 - 13 of 13
Full-Text Articles in Medicine and Health Sciences
General Practitioner Antimicrobial Stewardship Programme Study (Gaps): Protocol For A Cluster Randomised Controlled Trial, Minyon L. Avent, Malene Hansen, Charles Gilks, Chris Del Mar, Kate Halton, Hanna Sidjabat, Lisa Hall, Annette J. Dobson, David L. Paterson, Mieke Van Driel
General Practitioner Antimicrobial Stewardship Programme Study (Gaps): Protocol For A Cluster Randomised Controlled Trial, Minyon L. Avent, Malene Hansen, Charles Gilks, Chris Del Mar, Kate Halton, Hanna Sidjabat, Lisa Hall, Annette J. Dobson, David L. Paterson, Mieke Van Driel
Malene Hansen
Background There is a strong link between antibiotic consumption and the rate of antibiotic resistance. In Australia, the vast majority of antibiotics are prescribed by general practitioners, and the most common indication is for acute respiratory infections. The aim of this study is to assess if implementing a package of integrated, multifaceted interventions reduces antibiotic prescribing for acute respiratory infections in general practice. Methods/design This is a cluster randomised trial comparing two parallel groups of general practitioners in 28 urban general practices in Queensland, Australia: 14 intervention and 14 control practices. The protocol was peer-reviewed by content experts who were …
Adverse Events In Patients Taking Macrolide Antibiotics Versus Placebo For Any Indication (Protocol), Malene Hansen, Sarah Thorning, Jeffrey Aronson, Elaine Beller, Paul Glasziou, Tammy Hoffmann, Chris Del Mar
Adverse Events In Patients Taking Macrolide Antibiotics Versus Placebo For Any Indication (Protocol), Malene Hansen, Sarah Thorning, Jeffrey Aronson, Elaine Beller, Paul Glasziou, Tammy Hoffmann, Chris Del Mar
Malene Hansen
Our primary objective is to quantify the incidence of any reported adverse event in patients taking macrolide antibiotics compared to placebo for any indication. The adverse events will be handled separately as adverse reactions, adverse effects, serious adverse events or subsequent carriage of resistant bacteria. Our secondary objective is to quantify the overall incidence of any reported adverse events in patients taking macrolide antibiotics compared to placebo.
Parents’ Beliefs And Knowledge About The Management Of Acute Otitis Media: A Qualitative Study, Malene Hansen, Janine Howlett, Chris Del Mar, Tammy Hoffmann
Parents’ Beliefs And Knowledge About The Management Of Acute Otitis Media: A Qualitative Study, Malene Hansen, Janine Howlett, Chris Del Mar, Tammy Hoffmann
Malene Hansen
Acute otitis media is a common reason for antibiotic prescribing, despite strong evidence that antibiotics provide minimal benefit. Studies have demonstrated that patients’ (or parents’) expectations of antibiotics often influence general practitioners’ (GPs) decision to prescribe antibiotics, but few have explored parents’ expectations of the management of infections in children, or which factors influence the development of these expectations. This study aimed to explore parents’ knowledge and beliefs about the management of acute otitis media in children.
Antibiotic Resistance: What Can Be Done In Primary Care To Alleviate The Crisis?, Malene Hansen, Tammy Hoffmann, Amanda Mccullough, Mieke Van Driel, Chris Del Mar
Antibiotic Resistance: What Can Be Done In Primary Care To Alleviate The Crisis?, Malene Hansen, Tammy Hoffmann, Amanda Mccullough, Mieke Van Driel, Chris Del Mar
Malene Hansen
Numerous opportunities are available in primary care for alleviating the crisis of increasing antibiotic resistance. Preventing patients from developing an acute respiratory infection (ARI) will obviate any need for antibiotic use downstream. Hygiene measures such as physical barriers and hand hygiene, and possibly vaccination and exercise, may be effective. Also, a large range of complementary and alternative medicines (e.g. zinc, vitamin C and probiotics) are proposed for preventing and treating ARIs, but evidence for efficacy is scarce.
National Clinical Guideline On Treatment With Tympanostomy Tubes – Diagnosis Of Acute Otitis Media And Indications For Tympanostomy Tubes Among Children Aged 0-5 Years, Malene Hansen
Malene Hansen
No abstract provided.
Quality Indicators For Treatment Of Respiratory Tract Infections? An Assessment By Danish General Practitioners, Malene Hansen, Lars Bjerrum, Bente Gahrn-Hansen, Rene De Pont Christensen, Jesper Davidsen, Anders Munck, Dorte Jarbøl
Quality Indicators For Treatment Of Respiratory Tract Infections? An Assessment By Danish General Practitioners, Malene Hansen, Lars Bjerrum, Bente Gahrn-Hansen, Rene De Pont Christensen, Jesper Davidsen, Anders Munck, Dorte Jarbøl
Malene Hansen
Background: In 2008, a set of 41 quality indicators for antibiotic treatment of respiratory tract infections (RTIs) in general practice were developed in an international setting as part of the European project HAPPY AUDIT. Objectives: To investigate Danish general practitioners' (GPs') assessment of a set of internationally developed quality indicators and to explore if there is an association between the GPs' assessment of the indicators and their practice characteristics as well as their antibiotic prescription pattern. Methods: A total of 102 Danish GPs were invited to assess the 41 quality indicators. The GPs were categorized into two groups according to …
Predictors For Antibiotic Prescribing In Patients With Exacerbations Of Copd In General Practice, Carles Llor, Lars Bjerrum, Anders Munck, Malene Hansen, Gloria Córdoba, Eva Strandberg, Ingvar Ovhed, Ruta Radzeviciene, Josep Cots, Anatoliy Reutskiy, Lidia Cabalelro
Predictors For Antibiotic Prescribing In Patients With Exacerbations Of Copd In General Practice, Carles Llor, Lars Bjerrum, Anders Munck, Malene Hansen, Gloria Córdoba, Eva Strandberg, Ingvar Ovhed, Ruta Radzeviciene, Josep Cots, Anatoliy Reutskiy, Lidia Cabalelro
Malene Hansen
Background: The aim of this study was to describe the antibiotic prescribing rate in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), to analyse predictors for antibiotic prescribing and to explore the influence of the use C-reactive protein (CRP) rapid test. Methods: A cross-sectional study was carried out in January and February 2008 in primary care. General practitioners (GPs) from six countries (Denmark, Sweden, Lithuania, Russia, Spain and Argentina) registered all patients with AECOPD during a 3-week period. A multilevel logistic regression model was estimated using two hierarchical levels, (i) patients and (ii) physicians, and was used to …
Factors Associated With Antibiotic Prescribing In Children With Otitis Media, Christina Ryborg, Jens Søndergaard, Jørgen Lous, Anders Munck, Pia Larsen, Malene Hansen, Janus Thomsen
Factors Associated With Antibiotic Prescribing In Children With Otitis Media, Christina Ryborg, Jens Søndergaard, Jørgen Lous, Anders Munck, Pia Larsen, Malene Hansen, Janus Thomsen
Malene Hansen
Acute otitis media (AOM) is often treated with antibiotics. However, initial observation is recommended. Denmark has a low use of antibiotics compared with other countries, but the total use of antibiotics has increased by 32% during the last decade, and it is important to know whether general practitioners (GPs) prescribe antibiotics according to guidelines. Objective. The aim of the study was to analyse associations between GPs’ antibiotic prescribing for AOM and symptoms, diagnoses, and characteristics of children. Methods. A cohort study where GPs consecutively included 954 children between 0 and 7 years old with a new ear symptom was carried …
Treatment Of Acute Otitis Media In General Practice: Quality Variations Across Countries, Malene Hansen, Dorte Jarbøl, Bente Gahrn-Hansen, René Depont Christensen, Anders Munck, Christina Ryborg, Lars Bjerrum
Treatment Of Acute Otitis Media In General Practice: Quality Variations Across Countries, Malene Hansen, Dorte Jarbøl, Bente Gahrn-Hansen, René Depont Christensen, Anders Munck, Christina Ryborg, Lars Bjerrum
Malene Hansen
Background: Recommendations for antibiotic treatment of acute otitis media (AOM) have changed over the years, and today many experts recommend initial observation. However, antibiotic prescribing should be considered in children aged <2 years or if AOM is accompanied by discharging ear.Objectives: To investigate the quality of treatment of AOM in general practice and to explore the influence of selected GP and patient characteristics on antibiotic prescribing.Methods: During the winter>2008, a prospective registration of patients diagnosed with AOM was conducted in general practice in Lithuania, Kaliningrad, Spain, Argentina, Sweden and Denmark. Some 1175 patients diagnosed with AOM were registered. Information about age and sex of the patient, duration of symptoms (days), temperature >38.5°C, ear discharge and the antibiotic treatment given was recorded.Results: Danish GPs had the lowest antibiotic prescription rate for AOM [72.7% (95% confidence interval (CI) = …
Association Between Prescribing Patterns Of Anti-Asthmatic Drugs And Clinically Uncontrolled Asthma: A Cross-Sectional Study, Jesper Davidsen, Jesper Hallas, Jens Søndergaard, René Christensen, Hans Christian Siersted, Malene Hansen, Thomas Knudsen, Jesper Lykkegaard, Morten Anderson
Association Between Prescribing Patterns Of Anti-Asthmatic Drugs And Clinically Uncontrolled Asthma: A Cross-Sectional Study, Jesper Davidsen, Jesper Hallas, Jens Søndergaard, René Christensen, Hans Christian Siersted, Malene Hansen, Thomas Knudsen, Jesper Lykkegaard, Morten Anderson
Malene Hansen
Objective: Studies based on prescription data have shown that many asthmatics tend to use large quantities of inhaled beta-2-agonists, suggesting poorly controlled disease. The aim of the present study was to investigate the association between clinically uncontrolled asthma and prescribing patterns of anti-asthmatic drugs with a primary focus on short-acting beta-2-agonists (SABA). Methods: In a cross-sectional study 357 subjects, selected by their prescriptions of inhaled beta-2-agonists in Odense Pharmaco-Epidemiological Database, underwent individual clinical assessment including the Asthma Control Questionnaire (ACQ) and spirometry. The associations between uncontrolled asthma (ACQ score ≥ 1.50) and individual anti-asthmatic prescribing were analysed by means of …
Health Alliance For Prudent Antibiotic Prescribing In Patients With Respiratory Tract Infections (Happy Audit) -Impact Of A Non-Randomised Multifaceted Intervention Programme, Lars Bjerrum, Anders Munck, Bente Gahrn-Hansen, Malene Hansen, Dorte Jarbøl, Gloria Córdoba, Carles Llor, Josep Cots, Silvia Hernández, B Lápez-Valcárcel, Antoñia Pérez, Lidia Caballero, Walter Von Der Heyde, Ruta Radzeviciene, Arnoldas Jurgutis, Anatoliy Reutskiy, Elena Egorova, Eva Strandberg, Ingvar Ovhed, Sigvard Mölstad, Robert Stichele, Ria Benkó, Vera Vlahović-Palčevski, Christos Lionis, Marit Rønning
Health Alliance For Prudent Antibiotic Prescribing In Patients With Respiratory Tract Infections (Happy Audit) -Impact Of A Non-Randomised Multifaceted Intervention Programme, Lars Bjerrum, Anders Munck, Bente Gahrn-Hansen, Malene Hansen, Dorte Jarbøl, Gloria Córdoba, Carles Llor, Josep Cots, Silvia Hernández, B Lápez-Valcárcel, Antoñia Pérez, Lidia Caballero, Walter Von Der Heyde, Ruta Radzeviciene, Arnoldas Jurgutis, Anatoliy Reutskiy, Elena Egorova, Eva Strandberg, Ingvar Ovhed, Sigvard Mölstad, Robert Stichele, Ria Benkó, Vera Vlahović-Palčevski, Christos Lionis, Marit Rønning
Malene Hansen
Background: Excessive use of antibiotics is worldwide the most important reason for development of antimicrobial resistance. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious impact on all countries. Initiatives have been taken to improve the quality of antibiotic prescribing in primary care, but only few studies have been designed to determine the effectiveness of multifaceted strategies across countries with different practice setting. The aim of this study was to evaluate the impact of …
Quality Indicators For Diagnosis And Treatment Of Respiratory Tract Infections In General Practice: A Modified Delphi Study, Malene Hansen, Lars Bjerrum, Bente Gahrn-Hansen, Dorte Jarbøl
Quality Indicators For Diagnosis And Treatment Of Respiratory Tract Infections In General Practice: A Modified Delphi Study, Malene Hansen, Lars Bjerrum, Bente Gahrn-Hansen, Dorte Jarbøl
Malene Hansen
Objective.To develop a set of quality indicators focusing on the diagnosis and treatment of respiratory tract infections in general practice. Design. A modified 2-round Delphi study. Setting.General practice. Subjects. A panel of 27 experts (13 countries) comprising mainly general practitioners, clinical microbiologists, and clinical pharmacologists were asked to rate the relevance of 59 quality indicators for diagnosis and treatment of respiratory tract infections with regard to reducing antimicrobial resistance and improving patient health. A thorough literature review was carried out to ensure that all potential quality indicators were considered. Outcome. Consensus for a quality indicator was reached if ≥75% of …
Health Alliance For Prudent Prescribing, Yield And Use Of Antimicrobial Drugs In The Treatment Of Respiratory Tract Infections (Happy Audit), Lars Bjerrum, Anders Munck, Bente Gahrn-Hansen, Malene Hansen, Dorte Jarboel, Carl Llor, Josep Cots, Silvia Hernndez, Beatriz Lápez-Valcrcel, Antõia Pérez, Lidia Caballero, Walter Von Der Heyde, Ruta Radzeviviene, Arnoldas Jurgutis, Anatoliy Reutskiy, Elena Egorova, Eva Strandberg, Ingvar Ovhed, Sigvard Mölstad, Robert Vander Stichele, Ria Benkó, Vera Vlahović-Palčevski, Christos Lionis, Marit Rønning
Health Alliance For Prudent Prescribing, Yield And Use Of Antimicrobial Drugs In The Treatment Of Respiratory Tract Infections (Happy Audit), Lars Bjerrum, Anders Munck, Bente Gahrn-Hansen, Malene Hansen, Dorte Jarboel, Carl Llor, Josep Cots, Silvia Hernndez, Beatriz Lápez-Valcrcel, Antõia Pérez, Lidia Caballero, Walter Von Der Heyde, Ruta Radzeviviene, Arnoldas Jurgutis, Anatoliy Reutskiy, Elena Egorova, Eva Strandberg, Ingvar Ovhed, Sigvard Mölstad, Robert Vander Stichele, Ria Benkó, Vera Vlahović-Palčevski, Christos Lionis, Marit Rønning
Malene Hansen
Abstract. Background. Excessive and inappropriate use of antibiotics is considered to be the most important reason for development of bacterial resistance to antibiotics. As antibiotic resistance may spread across borders, high prevalence countries may serve as a source of bacterial resistance for countries with a low prevalence. Therefore, bacterial resistance is an important issue with a potential serious impact on all countries. The majority of respiratory tract infections (RTIs) are treated in general practice. Most infections are caused by virus and antibiotics are therefore unlikely to have any clinical benefit. Several intervention initiatives have been taken to reduce the inappropriate …