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Full-Text Articles in Medicine and Health Sciences

Longitudinal Changes In Visual Acuity In Keratoconus, Larry J. Davis, Kenneth B. Schechtman, Brad S. Wilson, Carol E. Rosenstiel, Colleen H. Riley, David P. Libassi, Ralph E. Gundel, Louis Rosenberg, Mae O. Gordon, Karla Zadnik Jan 2006

Longitudinal Changes In Visual Acuity In Keratoconus, Larry J. Davis, Kenneth B. Schechtman, Brad S. Wilson, Carol E. Rosenstiel, Colleen H. Riley, David P. Libassi, Ralph E. Gundel, Louis Rosenberg, Mae O. Gordon, Karla Zadnik

Larry Davis

Purpose.
The present investigation aimed to identify factors that predict reduced visual acuity in keratoconus from a prospective, longitudinal study.

Methods.
This report from the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study used 7 years of follow-up data from 953 CLEK subjects who did not have penetrating keratoplasty in either eye at baseline and who provided enough data to compute the slope of the change over time in high- or low-contrast best-corrected visual acuity (BCVA). Outcome measures included these slopes and whether the number of letters correctly read decreased by 10 letters or more in at least one eye in …


Repeatability Of Corneal Topography Measurement In Keratoconus With The Tms-1, Larry Davis, Timothy T. Mcmahon, Robert J. Anderson, Cynthia Roberts, Ashraf M. Mahmoud, Loretta B. Szczotka-Flynn, Thomas W. Raasch, Nina E. Friedman Apr 2005

Repeatability Of Corneal Topography Measurement In Keratoconus With The Tms-1, Larry Davis, Timothy T. Mcmahon, Robert J. Anderson, Cynthia Roberts, Ashraf M. Mahmoud, Loretta B. Szczotka-Flynn, Thomas W. Raasch, Nina E. Friedman

Larry Davis

Purpose. The purpose of this study was to report the test–retest variability of simulated indices derived from the TMS-1 topography instrument (Tomey Technology, Waltham, MA) in keratoconus subjects enrolled in the Collaborative Longitudinal Evaluation of Keratoconus (CLEK) Study. Methods. Four images were taken at an initial visit and at a repeat visit several weeks later. From these images, 17 indices were simulated from published formulas. Mixed-model analysis was used on test–retest data from the TMS-1 videokeratography instrument during the baseline year. This analysis yields estimates of within- and between-visit variability. Results. Repeatability analysis revealed that within-visit standard errors were 1.0 …


Standardized Rigid Contact Lens Fitting Protocol For Keratoconus, Larry Davis, Timothy B. Edrington, Joseph T. Barr, Karla Zadnik, Ralph E. Gundel, David P. Libassi, Timothy T. Mcmahon, Mae O. Gordon Jun 1996

Standardized Rigid Contact Lens Fitting Protocol For Keratoconus, Larry Davis, Timothy B. Edrington, Joseph T. Barr, Karla Zadnik, Ralph E. Gundel, David P. Libassi, Timothy T. Mcmahon, Mae O. Gordon

Larry Davis

Keratoconus is typically managed by a variety of rigid contact lens fitting techniques and lens designs. The two most fundamental fitting techniques are apical corneal touch (including divided or three-point touch) and apical clearance. In the course of designing a multi-center study of keratoconus patients, a standardized keratoconus fitting protocol was developed. All contact lens parameter options are uniform except for base curve and secondary curve radii, which are determined by interpretation of fluorescein patterns using the CLEK Study trial lens set and protocol. The initial trial lens's base curve is the average keratometric reading; sequentially steeper lenses are applied …