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Full-Text Articles in Medicine and Health Sciences
Dietary Total Isoflavone Intake Is Associated With Lower Systolic Blood Pressure: The Coronary Artery Risk Development In Young Adults (Cardia) Study, S. I. Richardson, L. M. Steffen, K. Swett, C. Smith, L. Burke, X. Zhou, J. M. Shikany, C. J. Rodriguez
Dietary Total Isoflavone Intake Is Associated With Lower Systolic Blood Pressure: The Coronary Artery Risk Development In Young Adults (Cardia) Study, S. I. Richardson, L. M. Steffen, K. Swett, C. Smith, L. Burke, X. Zhou, J. M. Shikany, C. J. Rodriguez
Journal Articles
The effect of dietary isoflavone intake on systolic blood pressure (SBP) has not been studied in a large community-based cohort inclusive of African Americans. The authors analyzed data from the year 20 examination of the Coronary Artery Risk Development in Young Adults (CARDIA) study, including medical history, physical examination, and dietary intake surveys for 3142 participants. Multivariable linear regression models controlled for age, sex, body mass index, smoking, physical activity, and intakes of alcohol and total energy. Effect modification by race was tested. Overall, patients with hypertension had a lower daily intake of total dietary isoflavones (2.2+/-5.2 mg/d vs 4.1+/-11.7 …
Cf Healthcare Workers Feel Unprepared In Providing Suitable End Of Life Care And Desire More Education: Results Of A Nationwide Survey, J. Goggin, R. I. Cohen
Cf Healthcare Workers Feel Unprepared In Providing Suitable End Of Life Care And Desire More Education: Results Of A Nationwide Survey, J. Goggin, R. I. Cohen
Journal Articles
INTRODUCTION: Little is known about the depth of knowledge and preparedness of CF caregivers in delivering end of life and palliative care to CF patients and families. METHOD: Nationwide survey questionnaires for CF care providers using the CF Foundation Listserv electronic web-based tool. RESULTS: The majority of non-physician CF care providers (55%) had more than 15years of experience in their discipline and 84% of physician had greater than 15years of experience. The majority reported that they felt "somewhat" or "very" involved in palliative or end of life care in their current role. Yet, when asked whether they felt adequately prepared …
Elevate Wellness: Unlocking The Potential Of Creative Problem Solving To Improve Wellness In Residency Programs., B. Pathak, E. Parry, L. Block, S. V. Desai
Elevate Wellness: Unlocking The Potential Of Creative Problem Solving To Improve Wellness In Residency Programs., B. Pathak, E. Parry, L. Block, S. V. Desai
Journal Articles
No abstract provided.
Pomalidomide Reverses Gamma-Globin Silencing Through The Transcriptional Reprogramming Of Adult Hematopoietic Progenitors, B. M. Dulmovits, A. O. Appiah-Kubi, J. Papoin, M. He, Y. Al-Abed, S. Didier, M. Gould, S. Husain-Krautter, S. A. Singh, A. Vlachos, S. L. Allen, J. M. Lipton, J. M. Liu, L. Blanc, +7 Additional Authors
Pomalidomide Reverses Gamma-Globin Silencing Through The Transcriptional Reprogramming Of Adult Hematopoietic Progenitors, B. M. Dulmovits, A. O. Appiah-Kubi, J. Papoin, M. He, Y. Al-Abed, S. Didier, M. Gould, S. Husain-Krautter, S. A. Singh, A. Vlachos, S. L. Allen, J. M. Lipton, J. M. Liu, L. Blanc, +7 Additional Authors
Journal Articles
Current therapeutic strategies for sickle cell anemia are aimed at reactivating fetal hemoglobin. Pomalidomide, a third-generation immunomodulatory drug, was proposed to induce fetal hemoglobin production by an unknown mechanism. Here, we report that pomalidomide induced a fetal-like erythroid differentiation program, leading to a reversion of gamma-globin silencing in adult human erythroblasts. Pomalidomide acted early by transiently delaying erythropoiesis at the BFU-E/CFU-E transition, but without affecting terminal differentiation. Further, the transcription networks involved in gamma-globin repression were selectively and differentially affected by pomalidomide including BCL11A, SOX6, IKZF1, KLF1, and LSD1. IKAROS (IKZF1), a known target of pomalidomide, was degraded by the …