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Full-Text Articles in Medicine and Health Sciences
Evaluating Blood-Brain Barrier Permeability In Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage, J. Ivanidze, K. Kesavabhotla, O. N. Kallas, D. Mir, H. Baradaran, A. Gupta, A. Z. Segal, J. Claassen, P. C. Sanelli
Evaluating Blood-Brain Barrier Permeability In Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage, J. Ivanidze, K. Kesavabhotla, O. N. Kallas, D. Mir, H. Baradaran, A. Gupta, A. Z. Segal, J. Claassen, P. C. Sanelli
Journal Articles
BACKGROUND AND PURPOSE: Patients with SAH are at increased risk of delayed infarction. Early detection and treatment of delayed infarction remain challenging. We assessed blood-brain barrier permeability, measured as permeability surface area product, by using CTP in patients with SAH with delayed infarction. MATERIALS AND METHODS: We performed a retrospective study of patients with SAH with delayed infarction on follow-up NCCT. CTP was performed before the development of delayed infarction. CTP data were postprocessed into permeability surface area product, CBF, and MTT maps. Coregistration was performed to align the infarcted region on the follow-up NCCT with the corresponding location on …
Potholes And Molehills: Bias In The Diagnostic Performance Of Diffusion-Tensor Imaging In Concussion, R. Watts, A. Thomas, C. G. Filippi, J. P. Nickerson, K. Freeman
Potholes And Molehills: Bias In The Diagnostic Performance Of Diffusion-Tensor Imaging In Concussion, R. Watts, A. Thomas, C. G. Filippi, J. P. Nickerson, K. Freeman
Journal Articles
PURPOSE: To investigate the extent of bias in a clinical study involving "pothole analysis" of diffusion-tensor imaging (DTI) data used to quantify white matter lesion load in diseases with a heterogeneous spatial distribution of pathologic findings, such as mild traumatic brain injury (TBI), and create a mathematical model of the bias. MATERIALS AND METHODS: Use of the same reference population to define normal findings and make comparisons with a patient group introduces bias, which potentially inflates reported diagnostic performance. In this institutional review board-approved prospective observational cohort study, DTI data were obtained in 20 patients admitted to the emergency department …