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Full-Text Articles in Medicine and Health Sciences
Investigation Into The Prevalence Of A Novel Dendritic-Like Cell Subset In Vivo, Kristin Griffiths, Jonathan Tan, Helen O'Neill
Investigation Into The Prevalence Of A Novel Dendritic-Like Cell Subset In Vivo, Kristin Griffiths, Jonathan Tan, Helen O'Neill
Jonathan Tan
A novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8+ T cells. This paper shows the subset to be unique to spleen and blood, with a similar, but possibly functionally distinct subset also present in bone marrow. The prevalence of the subset is low; ~6% of all dendritic and myeloid cells in the …
Spleen As A Site For Hematopoiesis Of A Distinct Antigen Presenting Cell Type, Helen O'Neill, Kristin Griffiths, Pravin Periasamy, Rebecca Hinton, Ying-Ying Hey, Sawang Petvises, Jonathan Tan
Spleen As A Site For Hematopoiesis Of A Distinct Antigen Presenting Cell Type, Helen O'Neill, Kristin Griffiths, Pravin Periasamy, Rebecca Hinton, Ying-Ying Hey, Sawang Petvises, Jonathan Tan
Jonathan Tan
While spleen and other secondary tissue sites contribute to hematopoiesis, the nature of cells produced and the environment under which this happens are not fully defined. Evidence is reviewed here for hematopoiesis occurring in the spleen microenvironment leading to the production of tissue-specific antigen presenting cells. The novel dendritic-like cell identified in spleen is phenotypically and functionally distinct from other described antigen presenting cells. In order to identify these cells as distinct, it has been necessary to show that their lineage origin and progenitors differ from that of other known dendritic and myeloid cell types. The spleen therefore represents a …