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Full-Text Articles in Medicine and Health Sciences
Novel Splenic Antigen-Presenting Cells Derive From A Lin-C-Kitlo Progenitor, Pravin Periasamy, Jonathan Tan, Helen O'Neill
Novel Splenic Antigen-Presenting Cells Derive From A Lin-C-Kitlo Progenitor, Pravin Periasamy, Jonathan Tan, Helen O'Neill
Jonathan Tan
No abstract provided.
Investigation Into The Prevalence Of A Novel Dendritic-Like Cell Subset In Vivo, Kristin Griffiths, Jonathan Tan, Helen O'Neill
Investigation Into The Prevalence Of A Novel Dendritic-Like Cell Subset In Vivo, Kristin Griffiths, Jonathan Tan, Helen O'Neill
Jonathan Tan
A novel dendritic-like cell subset termed L-DC was recently identified in murine spleen based on marker expression of a homogeneous cell population derived from long-term culture of neonatal spleen. The function of L-DC is distinct from other splenic dendritic and myeloid cell subsets because of their high endocytic capacity and their ability to cross-present antigen to CD8+ T cells. This paper shows the subset to be unique to spleen and blood, with a similar, but possibly functionally distinct subset also present in bone marrow. The prevalence of the subset is low; ~6% of all dendritic and myeloid cells in the …