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Diclazuril Protects Against Maternal Gastrointestinal Syndrome And Congenital Toxoplasmosis, Helieh S. Oz, Thomas Tobin
Diclazuril Protects Against Maternal Gastrointestinal Syndrome And Congenital Toxoplasmosis, Helieh S. Oz, Thomas Tobin
Internal Medicine Faculty Publications
BACKGROUND: Toxoplasmosis is a common cause of foodborne, gastrointestinal and congenital syndrome with particularly severe or unknown health consequences. There is no safe and effective preventive or therapeutic modality against congenital toxoplasmosis or to eliminate the persistent chronic infection.
HYPOTHESIS: Diclazuril to be safe in pregnancy and effective against gastrointestinal toxoplasmosis.
METHODS: CD1 programmed pregnant mice were divided into groups and administered a diet containing diclazuril, or sham control. Treatments were initiated on Day 5 of pregnancy and continued until Day 16 when dams were euthanatized. On Day 8 of pregnancy dams were infected intraperitoneally with escalating doses of tachyzoites …