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Novel Implications Of Lingo-1 And Its Signaling Partners In Schizophrenia, F Fernandez-Enright, J L. Andrews, K A. Newell, C Pantelis, Xu-Feng Huang
Novel Implications Of Lingo-1 And Its Signaling Partners In Schizophrenia, F Fernandez-Enright, J L. Andrews, K A. Newell, C Pantelis, Xu-Feng Huang
Illawarra Health and Medical Research Institute
Myelination and neurite outgrowth both occur during brain development, and their disturbance has been previously been implicated in the pathophysiology of schizophrenia. Leucine-rich repeat and immunoglobulin domain-containing protein (Lingo-1) is a potent negative regulator of axonal myelination and neurite extension. As co-factors of Lingo-1 signaling (Nogo receptor (NgR), With No Lysine (K) (WNK1) and Myelin transcription factor 1 (Myt1)) have been implicated in the genetics of schizophrenia, we explored for the first time the role of Lingo-1 signaling pathways in this disorder. Lingo-1 protein, together with its co-receptor and co-factor proteins NgR, tumor necrosis factor (TNF) receptor orphan Y (TROY), …