Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Glutamine (2)
- Alanine (1)
- Alzheimer's disease (1)
- Amyloid (1)
- Amyloid plaques (1)
-
- Amyloid-beta (1)
- Antioxidants (1)
- Athletics (1)
- Biochemistry (1)
- Bone (1)
- Brain (1)
- Breast cancer (1)
- Cancer cells (1)
- Celiac (1)
- Computational Chemistry (1)
- Cortisol (1)
- Dissertation (1)
- Fatigue (1)
- Gluten (1)
- Invade (1)
- Isorhamnetin (1)
- Lactate (1)
- Lung (1)
- MRI (1)
- Medicinal Chemistry (1)
- Metabolomics (1)
- Metastasis (1)
- Microenvironment (1)
- Mood (1)
- Naringenin (1)
Articles 1 - 7 of 7
Full-Text Articles in Medicine and Health Sciences
Breast Cancer Sub-Clones That Metastasize To Lung And Bone Exhibit Different Metabolic Preferences, Mollie Merrell
Breast Cancer Sub-Clones That Metastasize To Lung And Bone Exhibit Different Metabolic Preferences, Mollie Merrell
Honors Theses
Metastasis is responsible for the majority of cancer related deaths. In breast cancer the lungs and bones are the major sites for metastasis. Previous studies used the metastatic aggressive MDA-MB-231 breast cancer line to isolate sub-clones that preferentially invade the lungs (LM line) or bones (BoM line). While genes associated with the tissue specific metastasis have been identified, it is unknown if metabolic adaptations contribute to the growth of the LM and BoM lines in their respective organs. The goal of this study was to test the hypothesis that the LM and BoM lines exhibit differences in glucose and glutamine …
The Raphe-Hippocampal Tract And Its Age Differences: Diffusion Tensor Imaging And Probabilistic Tractography Study, Ashley Sekul
The Raphe-Hippocampal Tract And Its Age Differences: Diffusion Tensor Imaging And Probabilistic Tractography Study, Ashley Sekul
Honors Theses
The raphe-hippocampal tract links the raphe nuclei to the hippocampus and is responsible for the production of the neurotransmitter serotonin. The hippocampus is key in regulating emotional and stress responses. This study utilized diffusion tensor imaging which uses Functional Magnetic Resonance Imaging to provide scans of the brain for analyzing differences in the raphe-hippocampal tract as one ages. In this specific study, 491 samples were visually analyzed to gather data about the fractional anisotropy of the raphe nuclei in both male and female brains ranging from 6 to 85 years old. Through the ranking of images, some were discarded, and …
Studies Of Salvinorin-Based Antagonists To Elucidate Pertinent Interactions For Kappa Opioid Receptor Antagonism, Madeline Keane
Studies Of Salvinorin-Based Antagonists To Elucidate Pertinent Interactions For Kappa Opioid Receptor Antagonism, Madeline Keane
Honors Theses
Opioid abuse, leading to addiction and related deaths, has created a chronic epidemic in the United States for the past 30 years. This crisis has sprung from reliance on the prescription of opioid analgesics as the primary method for the management of pain in the 1990s. At that time, these drugs, specifically Purdue Pharma’s OxyContin, were marketed as non-addictive. Due to this systemic minimization of the addictive properties of opioid analgesics, as prescription rates increased, opioid-related mortality rates climbed. This epidemic continues to be pervasive, as opioid-related overdose resulted in 47,600 deaths in 2017. In addition to the opioid epidemic, …
A Study Of The Antioxidant Versus Pro-Oxidant Nature Of The Amyloid Beta Peptide And An Analysis Of The Natural Products, Isorhamnetin And Narignenin, As Antioxidants, Kaylee Holmes
Honors Theses
Alzheimer’s disease is a neurodegenerative disorder with no cure. Due to the widespread effects of this disease, abundant research efforts have gone towards finding a cure. The amyloid beta (Ab) peptide has been shown to be a potential cause of the disease due to destructive effects on tissues that it can have both by itself and through reactive oxygen species (ROS) generation. This study was performed in order to assess the structural properties of Ab42monomers, fibrils and oligomers, to assess the antioxidant versus pro-oxidant behavior of the Ab peptide, and to assess the antioxidant nature of the natural …
The Biochemical Characterization Of Cellular Retinoic Acid Binding Protein Type 1 (Crabp1), Emma Magna
The Biochemical Characterization Of Cellular Retinoic Acid Binding Protein Type 1 (Crabp1), Emma Magna
Honors Theses
The goal of this research was to express and purify Cellular Retinoic Acid Binding Protein Type 1 (CRABP1). CRABP1 binds to retinoic acid in the cell and shuttles the retinoic acid from one area in the cell to another. The overproduction of CRABP1 appears to be problematic because it can sequester the retinoic acid and prevent it from regulating gene expression. Previous studies have shown that increased levels of CRABP1 can result in tumor-promoting activity and disruption of lipid biology in the cell. Our objective was to express this protein in an inducible bacterial system, so that we could purify …
Identifying Metabolites As Markers Of Fatigue In Athletes, Christopher D. George
Identifying Metabolites As Markers Of Fatigue In Athletes, Christopher D. George
Honors Theses
Fatigue in athletes caused by inadequate rest and other stressors can be severely detrimental to their health, and yet there is no reliable way to measure and track fatigue. Many classical measures of fatigue like body mass and resting heart rate are not reliable ways to track the physical fatigue of an athlete because they can change with many factors. In addition, it is not known how academic stress on top of physical stress affects fatigue. Metabolomics is a relatively new area of study and tracking metabolites offers the possibility to produce biomarkers to assess fatigue. This study collected saliva …
Evaluating A Culprit: A Review Of The Biochemical Mechanisms Of Non-Celiac Gluten Intolerance, Callie Cinque
Evaluating A Culprit: A Review Of The Biochemical Mechanisms Of Non-Celiac Gluten Intolerance, Callie Cinque
Honors Theses
Non-Celiac Gluten Intolerance (NCGI) has evaded biological and chemical mechanisms since it was first reported in 1978. Celiac Disease, a multi-system immune mediated disorder has long served as the most similar counterpart to NCGI. Less cases of celiac disease are going undiagnosed reflecting an improvement on sensitive and decisive diagnostic tools. However, NCGI has been significantly growing as a diagnosis over the past decade with little match or similarity to the markers found in celiac disease patients. Critical evaluation of NCGI theories, experimentation, and existing hypotheses is necessary. This review seeks to synthesize multiple disciplines of gluten research and enhance …