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Mesothelial Cells Regulate Immune Responses In Health And Disease: Role For Immunotherapy In Malignant Mesothelioma, Steven E. Mutsaers, Fiona J. Pixley, Cecilia M. PrêLe, Gerard F. Hoyne

Health Sciences Papers and Journal Articles

Highlights:

• Mesothelial and immune cell interactions play a crucial role in tissue homeostasis in the serosal cavities such as the pleura.

• Mesothelin is viewed as an attractive target for solid tumors, including malignant mesothelioma.

• Checkpoint inhibitor therapy has shown variable efficacy against malignant mesothelioma.

• CAR T cell therapies are being evaluated for malignant mesothelioma.

• Treatment of malignant mesothelioma will require multimodality approaches with immunotherapy central to future therapeutic approaches.

The mesothelium when first described was thought to function purely as a non-adhesive surface to facilitate intracoelomic movement of organs. However, the mesothelium is now recognized as a dynamic cellular membrane …